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β-Adrenoceptor activates endothelium-dependent release of nitric oxide in rat aorta

Acta Pharmacologica Sinica 1995年第5期 3-8页

作者： ZHENG Xiu-Feng, Chiu-Yin KWAN, Edwin E DANIEL(Department of Physiology, University of Hong Kong, Hong Kong Department of BiomedicalScience, McMaster University Hamilton, Ontario, Canada L8N 3Z5) Now in Department of Pharmacology, Zhejiang Medical University, Hangzhou 310031, China.

AIM:To examine the possible role of agents elevating camp to release NO from aortic en-dothelial cells. METHODS:NG-nitro-L-arg inine methylester (L-NAME) , an inhibitor of NO synthase, partially inhibited endothelium-dependent relaxation evoked in phenylephrine-precontracted rings by isoproterenol and abolished relaxation mediated by forskolin 0. 2 umol ***: In rings without en-dothelium, isoproterenol and forskolin were less effective relaxants and L-NAME had no effect on the responses. In methylene blue-treated rings isoproterenol- and forskolin-induced relaxation were prevented in both en-dothelium-intact and -denuded rings, but the inhibitory effects of methylene blue were significantly more in rings with endothelium than in those without. On the other hand, relaxation induced by sodium nitroprusside was not inhibited by L-NAME, but was inhibited by methylene blue in both the endothelium-intact and -denuded rings. The concentration relaxation curves to sodium nitroprusside after methylene bl

关键词： cyclic amp: methylene blue forskolin endothelium-derived relaxing factor vascular endothelium smooth muscle contraction

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