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Primary cutaneous anaplastic large cell lymphoma with overexpressed Ki-67 transitioning into systemic anaplastic large cell lymphoma:A case report

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World Journal of Clinical Cases 2023年第28期11卷 6889-6894页

作者： Hai-Xi Mu Xiao-Qiong Tang Department of Hematology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

BACKGROUND Primary cutaneous anaplastic large cell lymphoma(PC-ALCL)differs from systemic anaplastic large cell lymphoma(sALCL)in cell biological behavior,clinical features,treatment,and ***-ALCL has been reported to rarely transition into sALCL,but the underlying mechanism is not *** we report such a case with certain characteristics that shed light on *** SUMMARY Herein,we report a 43-year-old male with symptoms of a skin nodule and histologically confirmed PC-ALCL with high expression of *** three months of observation,two skin nodules re-appeared with muscle layer involvement and was histologically confirmed as *** months after receiving six cycles of CHOP regimen,the patient had pain in the chest and back,cough,shortness of breath,and night *** was confirmed as relapse of sALCL by immunohistochemistry and several organs,such as the lung were involved as shown by positron emission tomography/computed *** four cycles of DICE plus chidamide regimens followed by auto-hematopoietic stem cell transplantation(ASCT),complete remission(CR)duration was achieved for twelve months while the patient was on maintenance with chidamide(20 mg)*** This case had significantly high expression of Ki-67 when diagnosed as PC-ALCL initially and then transitioned into sALCL,which is ***-ASCT combined with demethylation drugs effectively maintained CR and prolonged progression free survival.

关键词： cutaneous lymphoma Anaplastic large cell lymphoma Ki-67 Auto hematopoietic stem cell transplantation Case report

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Clinicopathology, immunophenotype, T cell receptor gene rearrangement, Epstein-Barr virus status andp53 gene mutation of cutaneous extranodal NK/T-cell lymphoma, nasal-type

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Chinese Medical Journal 2013年第7期126卷 1281-1287页

作者： WANG Ting-ting XU Chen LIU Shan-ling KAN Bei RAN Yu-ping LIU Wei-ping LI Gan-di WANG Lin Department of Dermatovenereology West China Hospital Sichuan University Chengdu Sichuan 610041 China Department of Pathology West China Hospital Sichuan University Chengdu Sichuan 610041 China

Background Extranodal natural killer/T-cell （NK/T cell） lymphoma, nasal-type, is a rare lymphoma. Skin is the second most common site of involvement after the nasal cavity/nasalpharynx. The aim of this study was to investigate the clinicopathologic features, immunophenotype, T cell receptor （TCR） gene rearrangement, the association with Epstein-Barr virus （EBV） infection and p53 gene mutations of the lymphoma. Methods The clinicopathologic analysis, immunohistochemistry, in situ hybridization for EBERI/2, TCR gene rearrangement by polymerase chain reaction （PCR）, mutations of p53 gene analyzed by PCR and sequence analysis were employed in this study. Results In the 19 cases, the tumor primarily involved the dermis and subcutaneous layer. Immunohistochemical staining showed that most of the cases expressed CD45RO, CD56, CD3E, TIA-1 and GrB. Three cases were positive for CD3 and two cases were positive for CD30. Monoclonal TCRy gene rearrangement was found in 7 of 18 cases. The positive rate of EBERI/2 was 100%. No p53 gene mutation was detected on the exon 4-9 in the 18 cases. Fifteen cases showed Pro （proline）/Arg （arginine） single nucleotide polymorphisms （SNPs） on the exon 4 at codon 72. The expression of p53 protein was 72% （13/18）immunohistochemically. Conclusions cutaneous NK/T-cell lymphoma is a rare but highly aggressive lymphoma with poor prognosis. No p53 gene mutation was detected on the exon 4-9, and Pro/Arg SNPs on p53 codon 72 were detected in the cutaneous NK/T-cell lymphoma. The overexpression of p53 protein may not be the result of p53 gene mutation.

关键词： NK/T-cell cutaneous lymphoma p53 gene mutations Epstein-Barr virus

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