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cross-talking between autophagy and viral infection in mammalian cells

Frontiers in Biology 2010年第6期5卷 507-515页

作者： Hongya HAN Lishu ZHANG Xinxian DAI Yanpeng ZHENG College of Life Sciences&Bioengineering Beijing Jiaotong UniversityBeijing 100044China

Autophagy is a cellular process in degradation of long-lived proteins and organelles in the cytosol for maintaining cellular homeostasis,which has been linked to a wide range of human health and disease states,including viral *** viral infected cells exhibit a compli-cated cross-talking between autophagy and *** has been shown that autophagy interacts with both adaptive and innate *** adaptive immunity,viral antigens can be processed in autophagosomes by acidic proteases before major histocompatibility complex(MHC)class II *** innate immunity,autophagy may assist in the delivery of viral nucleic acids to endosomal TLRs and also functions as a part of the TLR-or-PKR-downstream *** was also reported to suppress the magnitude of host innate antiviral immunity in certain *** the other hand,viruses has evolved many strategies to combat or utilize the host autophagy for their own beneﬁ*** this review we discussed recent advances toward clarifying the cross-talking between autophagy and viral infection in mammalian cells.

关键词： cross-talking autophagy viral infection

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Systems-Based Interactome Analysis for Hematopoiesis Effect of Angelicae sinensis Radix: Regulated Network of Cell Proliferation towards Hemopoiesis

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Chinese Journal of Integrative Medicine 2019年第12期25卷 939-947页

作者： ZHENG Guang ZHANG He YANG Yun SUN Ying-li ZHANG Yan-jing CHEN Ju-ping HAO Ting LU Cheng GUO Hong-tao ZHANG Ge FAN Dan-ping HE Xiao-juan LU Ai-ping Information Science and Engineering School Lanzhou UniversityLanzhou(730000)China School of Biology Lanzhou UniversityLanzhou(730000)China Institute of Basic Research in Chinese Medicine China Academy of Chinese Medical SciencesBeijing(100700)China Department of Rheumatism the First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou(450000)China School of Chinese Medicine Hong Kong Baptist UniversityKowloon TongKowloonHong Kong SARChina

Objective: To explore the molecular-level mechanism on the hematopoiesis effect of Angelicae sinensis Radix(ASR) with systems-based interactome analysis. Methods: This systems-based interactome analysis was designed to enforce the workflow of "ASR(herb)→compound→target protein→internal protein actions→ending regulated protein for hematopoiesis". This workflow was deployed with restrictions on regulated proteins expresses in bone marrow and anemia disease and futher validated with experiments. Results: The hematopoiesis mechanism of ASR might be accomplished through regulating pathways of cell proliferation towards hemopoiesis with cross-talking agents of spleen tyrosine kinase(SYK), Janus kinase 2(JAK2), and interleukin-2-inducible T-cell kinase(ITK). The hematopoietic function of ASR was also validated by colonyforming assay performed on mice bone marrow cells. As a result, SYK, JAK2 and ITK were activated. Conclusion: This study provides a new approach to systematically study and predict the therapeutic mechanism for ASR based on interactome analysis towards biological process with experimental validations.

关键词： Angelicae sinensis Radix interactome cell proliferation hemopoiesis regulation cross-talking agents

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Evolutionarily Conserved DELLA-mediated Gibberellin Signaling in Plants

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Journal of Integrative Plant Biology 2008年第7期50卷 825-834页

作者： Xiu-Hua Gao Xian-Zhong Huang Sen-Lin Xiao Xiang-Dong Fu State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental Biology the Chinese Academy of Sciences National Center for Plant Gene Research Beijing 100101 China Laboratory of Agrobiotechnology College of Life Science Shihezi University Shihezi 832003 China

Gibberellins （GAs） play important roles in many essential plant growth and development processes. A family of nuclear growth-repressing DELLA proteins is the key component in GA signaling. GA perception is mediated by GID1, and the key event of GA signaling is the degradation of DELLA proteins via the 26S proteasome pathway. DELLA proteins integrating other plant hormones signaling and environmental cue modulating plant growth and development have been revealed. GA turning on the de-DELLA-repressing system is conserved, and independently establishes step-by-step recruitment of GA-stimulated GID1-DELLA interaction and DELLA growth-repression functions during land plant evolution. These discoveries open new prospects for the understanding of GA action and DELLA-mediated signaling in plants.

关键词： cross-talking DELLA proteins evolution GA signaling GID1.

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Research on Blind Source Separation for Machine Vibrations

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Wireless Sensor Network 2009年第5期1卷 453-457页

作者： Weiguo HUANG Shuyou WU Fangrang KONG Qiang WU 不详

Blind source separation is a signal processing method based on independent component analysis, its aim is to separate the source signals from a set of observations (output of sensors) by assuming the source signals independently. This paper reviews the general concept of BSS firstly;especially the theory for convolutive mixtures, the model of convolutive mixture and two deconvolution structures, then adopts a BSS algorithm for convolutive mixtures based on residual cross-talking error threshold control criteria, the simulation testing points out good performance for simulated mixtures.

关键词： Blind Source Separation Independent Component Analysis Convolutive Mixtures Machine Vibration Residual cross-talking Error

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