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cross-reaction of SARS-CoV Antigen with Autoantibodies in Autoimmune Diseases

Cellular & Molecular Immunology 2004年第4期1卷 304-307页

作者： YunshanWang ShanhuiSun HongShen LihuaJiang MaoxiuZhang DongjieXiao YangLiu XiaoliMa YongZhang NongjianGuo TanghongJia CentralLaboratory JinanCentralHospitalClinicalMedicalCollegeofShandongUniversityJinanChina. ShandongResearchCenterforTransplantationandTissueEngineering JinanChina.

To investigate the significance of the SARS-associated coronavirus (SARS-CoV) antibody,detected by ELISA and indirect immunofluorescence assays (IFA) for the SARS-CoV Vero E6 cell lysates,in non-SARS subjects, 114 serum samples from healthy controls and 104 serum specimens from autoimmune disease patients were *** results of ELISA showed that among 114 sera from healthy controls,4 (3.5%) were positive of SARS-CoV-IgG antibody and 114 (100%) were all negative of SARS-CoV-IgM antibody;the specificity of SARS-CoV-IgG antibody for SARS patients was 96.5%,but the specificity of both SARS-CoV-IgG and -IgM antibodies for SARS patients was 100%.In 58 cases with SLE,positive rates of SARS-CoV-IgG and -IgM antibodies were 32.8% (19/58) and 8.6% (5/58),respectively,in which 11 cases (19%) were positive of both SARS-CoV-IgG and -IgM antibodies;in 10 cases with SS,positive rate of both SARS-CoV-IgG and -IgM antibodies was 10% (1/10);in 16 cases with MCTD,positive rate of SARS-CoV-IgG was 37.5% (6/16),positive rate of both SARS-CoV-IgG and -IgM antibodies was 6.3% (1/16);in 20 cases with RA,one case was positive (5%) of ***,of all samples with positive SARS-CoV-IgG and -IgM antibodies for autoimmune diseases and healthy controls,SARS-CoV RNA and antibodies were all negative by RT-PCR and *** sera for negative or positive ELISA results were also negative or positive results using ELISA with Vero E6 cells *** studies showed that SARS-CoV Vero E6 cell lysates for the ELISA to detect SARS-CoV antibodies could lead to the false-positive reactions or cross-reactions of SARS-CoV antibodies in non-SARS diseases and healthy controls,and the false-positive reactions or cross-reactions were related to Vero E6 cell lysates and autoantibodies in non-SARS *** & Molecular Immunology.2004;1(4): 304-307.

关键词： SARS-CoV autoimmune disease cross-reaction

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cross-reaction between Gliadin and Different Food and Tissue Antigens

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Food and Nutrition Sciences 2013年第1期4卷 20-32页

作者： Aristo Vojdani Igal Tarash Immunosciences Lab. Inc. Los Angeles USA Immunosciences Lab. Inc. Los Angeles USA&Cyrex Labs LLC. Phoenix USA.

A subgroup of coeliac disease patients continues to experience symptoms even on a gluten-free diet (GFD). We attempted to determine whether these symptoms could be due to either cross-contamination with gluten-containing foods or cross-reactivity between α-gliadin and non-gluten foods consumed on a GFD. We measured the reactivity of affinity-purified polyclonal and monoclonal α-gliadin 33-mer peptide antibodies against gliadin and additional food antigens commonly consumed by patients on a GFD using ELISA and dot-blot. We also examined the immune reactivity of these antibodies with various tissue antigens. We observed significant immune reactivity when these antibodies were applied to cow’s milk, milk chocolate, milk butyrophilin, whey protein, casein, yeast, oats, corn, millet, instant coffee and rice. To investigate whether there was cross-reactivity between α-gliadin antibody and different tissue antigens, we measured the degree to which this antibody bound to these antigens. The most significant binding occurred with asialoganglioside, hepatocyte, glutamic acid decarboxylase 65, adrenal 21-hydroxylase, and various neural antigens. The specificity of anti-α-gliadin binding to different food and tissue antigens was demonstrated by absorption and inhibition studies. We also observed significant cross-reactivity between α-gliadin 33-mer and various food antigens, but some of these reactions were associated with the contamination of non-gluten foods with traces of gluten. The consumption of cross-reactive foods as well as gluten-contaminated foods may be responsible for the continuing symptoms presented by a subgroup of patients with coeliac disease. The lack of response of some CD patients may also be due to antibody cross-reactivity with non-gliadin foods. These should then be treated as gluten-like peptides and should also be excluded from the diet when the GFD seems to fail.

关键词： cross-reaction Gliadin Food Antigens Tissue Antigens Celiac Disease Gluten-Free Diet

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ME-PPD, derivative of PPD, significantly attenuating the skin sensitizing response by studies anchored to the skin sensitization AOP and clinical cross-reaction studies

ME-PPD, derivative of PPD, significantly attenuating the ski...

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中国毒理学会第九次全国毒理学大会

作者： Wenbo Xin Thomas Koch Carsten Goebel Global Product Stewardship Coty

The strong sensitizing potencies of the most important precursors of oxidative hair dyes,p-phenylenediamine（PPD） and p-toluylenediamine（PTD, i.e. 2-methyl-PPD） are well established,which are considered as the key sensitizers in hair dye allergic contact *** the rate of positive PPD patch test results in a large series of dermatitis patients is approximately 6.2% in North America and 4% in both Europe and ***, with the introduction of a methoxymethyl side chain into PPD, 2-methoxymethyl-pphenylenediamine（ME-PPD） was found to deliver excellent hair coloring performance while significantly reducingthe sensitizing potential compared to PPD and PTD. In in vitro studies, ME-PPD showed an attenuated innate immune response when analyzed for its protein reactivity and dendritic cell activation potential. In vivo, the effective concentration of ME-PPD necessary to induce an immune response 3-fold above vehicle control（EC3 value） in the local lymph node assay（LLNA） was 4.3%, indicating a moderate skin sensitizing potency compared to values of 0.1 and 0.17% for PPD and PTD, respectively. In addition, the skin sensitizing induction risk of ME-PPD under consumer hair dye usage conditions was assessed through a quantitative risk assessment（QRA） indicatingthat the risk was negligible compared to PPD or *** there is a substantial rate of cross-elicitation of allergic contact dermatitis to other important hair dye molecules（such asPTD） in PPD-allergic patients, the tolerance to ME-PPD was also studied in three patient populations in the USA and in *** 73 PPD-allergic patients were exposed to a hair dye product containing 2% ME-PPD instead of2% PPD for 30 or 45 min on their forearm（simulating hair dye use conditions） no elicitation response was observed in 45（62%）. Among the 28 PPD allergic patients that reacted to both ME-PPD and PPD under these conditions, 24（85%） showed a reduced reaction strength in response to ME-PPD. Hence based on the above s

关键词： hair dye PPD 2-methoxymethyl-p-phenylenediamine(ME-PPD) alternative methods mechanistic study QRA cross-reaction

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Occurrence of False-Positive Tests and cross-reactions Between COVID-19 and Dengue With Implications During Diagnosis:A Mixed Evidence Synthesis

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Infectious Microbes & Diseases 2023年第2期5卷 64-75页

作者： Daniel C.Digwo Chidinma P.Elebe Vincent N.Chigor Stella N.Madueke Christian K.Ezeh Anthony C.Ike Department of Microbiology University of NigeriaNsukkaEnugu StateNigeria.

This review aimed to assess the occurrence of false-positive serological reaction between dengue and coronavirus disease 2019(COVID-19)and its implications for *** syntheses were conducted by systematically reviewing available literature using multiple databases,including Web of Science,PubMed,Google Scholar and *** a total of 16 presented cases from clinical settings,cross-reaction to COVID-19 serological tests was observed in two(12.5%)dengue-positive patients,while 14 patients(87.5%)confirmed positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)showed a cross-reaction with dengue serological tests,leading to misdiagnosis and mismanagement by attending *** 1789 SARS-CoV-2-positive sera,cross-reaction to dengue serological tests was observed in 180 sera(10%),which is higher than the cross-reaction observed for SARS-CoV-2 in archived pre-COVID-19 sera positive for a dengue infection(75 of 811,9.2%,P=0.674).Clinicians in tropical regions are therefore advised to interpret serological tests with caution and use a more pragmatic approach to triage these infections.

关键词： COVID-19 cross-reaction dengue SARS-CoV-2

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High correlation of specific IgE sensitization between birch pollen, soy and apple allergens indicates pollen-food allergy syndrome among birch pollen allergic patients in northern China

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2016年第5期17卷 399-404页

作者： Guo-dong HAO Yi-wu ZHENG Zhi-xiang WANG Xing-ai KONG Zhi-jing SONG Xu-xin LAI Michael D.SPANGFORT Department of Allergy Tangshan Gongren Hospital Tangshan 063000 China ALK China Research ALK C uangzhou 510300 China

Background： Birch pollen sensitization and associated pollen-food syndrome among Chinese allergic patients have not been investigated. Methods： Sera from 203 allergic patients from the northern part of China and collected during February to July 2014 were investigated. Specific immunoglobulin E （IgE） against birch pollen extract Bet v and major birch pollen allergen Bet v 1 were measured using the ADVIA Centaur. The presence of major apple allergen Mal d 1 and soy bean allergen Gly m 4 specific IgE was measured by ImmunoCAP 100. Results： Among the 203 sere, 34 sera （16.7%） had specific IgE to Bet v and of these, 28 sere （82.4%） contained Bet v 1-specific IgE. Among the 28 sera with Bet v 1-specific IgE, 27 sera （96.4%） contained Mal d 1-specific IgE and 22 sera （78.6%） contained Gly m 4-specific igE. Of the 34 Bet v-positive sera, 6 sera （17.6%） contained no specific IgE for Bet v 1, Mal d 1, or Gly m 4. Almost all Bet v-positive sera were donated during the birch pollen season. Conclusions： The prevalence of birch allergy among patients visiting health care during pollen season can be as high as 16.7% in Tangshan City. The majority of Chinese birch allergic patients are IgE-sensitized to the major birch pollen allergen Bet v 1 as well as to the major apple allergen Mal d 1 and soy bean allergen Gly m 4. A relatively high number of patients （17.6%） are IgE-sensitized to birch pollen allergen（s） other than Bet v 1. The high prevalence of specific IgE to Mal d 1 and Gly m 4 among Bet v 1-sensitized patients indicates that pollen-food allergy syndrome could be of clinical relevance in China.

关键词： Apple Birch cross-reaction Pollen-food allergy Soy Specific immunoglobulin E (IgE)

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Immunogenicity of venoms from four snakes common in China and venom detection by species-specific antibody

Immunogenicity of venoms from four snakes common in China an...

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第七届全国野生动物生态与资源保护学术研讨会

作者： Jian-Fang Gao~1,Jin Wang~2,Xiao-Mei Ma~1,Xiang Ji~2 (1.Hangzhou Key Laboratory for Animal Adaptation and Evolution,School of Life Sciences,Hangzhou Normal Univerity,Hangzhou 310036,Zhejiang,China 2.Jiangsu Key Laboratory for Biodiversity and Biotechnology,College of Life Sciences,Nanjing Normal University,Nanjing 210046,Jiangsu,China)

We studied the immuno-relationship among venoms and commercial antivenoms of four snakes common in China,Bungarus multicinctus,Naja atra,Deinagkistrodon acutus and Gloydius *** of the venom components expressed antige... 详细信息

关键词： Snake venom Immunogenicity Detection Species-specific antibody cross-reaction

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