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Effect of ABCB1 C3435T Polymorphism on Clinical Outcomes in Kenyan HIV Patients on Lopinavir-Based Regimens

Journal of Pharmacy and Pharmacology 2017年第7期5卷 478-488页

作者： Kagia Richard Okalebo Faith Oluka Margaret Njoroge Anne Bulimo Wallace Department of Pharmacology and Pharmacognosy University of Nairobi Nairobi 00100 Kenya Department of Pharmacology Mount Kenya University Thika 00100 Kenya Kenyatta National Hospital Nairobi 00202 Kenya US Army Medical Research Unit Nairobi 00621 Kenya

ATP Binding Cassette sub-family B member 1 （ABCB1） affects disposition of many drugs and thus affects the pharmacokinetics of drugs and ultimately treatment response. Polymorphisms of ABCB 1 especially ABCB 1 C3435T polymorphism may thus affect pharmacokinetics of antiretroviral drugs and hence CD4 treatment response and other clinical outcomes of HIV patients. Methods： The study design was a historical cohort study and entailed collection of patient data. PureLink genomic DNA extraction mini kit was used for the extraction and purification of genomic DNA. TaqMan drug genotyping assay and protocol was used in the DNA amplification and genotyping. Data analysis was done using STATA software version 10. Results： Study participants with the CT genotype had lower creatinine levels after 6 months on lopinavir-based regimens compared with those with the CC genotype （p = 0.001）. In addition, the study participants with the CT genotype had consistently higher CD4 cell counts compared with those with the CC genotype from the time of ART switch but this was not statistically significant. However, there was no significant association between the ABCB 1 C3435T genotypes and haemoglobin and ALT levels. Conclusion： There was a significant association between ABCB1 C3435T polymorphism and creatinine levels 6 months after therapy on lopinavir-based regimens.

关键词： ABCB 1 C3435T polymorphism lopinavir-based regimens creatinine levels CD4 cell counts ALT.

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