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A high-strength mineralized collagen bone scaffold for large-sized cranial bone defect repair in sheep

Regenerative Biomaterials 2018年第5期5卷 283-292页

作者： Shuo Wang Zhijun Zhao Yongdong Yang Antonios G.Mikos Zhiye Qiu Tianxi Song Fuzhai Cui XiumeiWang Chunyang Zhang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced Materials of Ministry of EducationSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Neurosurgery The First Affiliated Hospital of Baotou Medical SchoolBaotou 014010China Dongzhimen Hospital Affiliated Beijing University of Chinese Medicine Beijing 100700China Department of Bioengineering Rice UniversityHoustonTX 77030USA Beijing Allgens Medical Science and Technology Co. Ltd.Beijing 100176China

Large-sized cranial bone defect repair presents a great challenge in the *** ideal cranioplasty materials to realize the functional and cosmetic recovery of the defect must have sufficient mechanical support,excellent biocompatibility,good osseointegration and biodegradability as *** this study,a high-strength mineralized collagen(MC)bone scaffold was developed with biomimetic composition,microstructure and mechanical properties for the repair of sheep largesized cranial bone defects in comparison with two traditional cranioplasty materials,polymethyl methacrylate and titanium *** compact MC scaffold showed no distinct pore structure and therefore possessed good mechanical *** strength and elastic modulus of the scaffold were much higher than those of natural cancellous bone and slightly lower than those of natural compact *** vitro cytocompatibility evaluation revealed that the human bone marrow mesenchymal stem cells(hBMSC)had good viability,attachment and proliferation on the compact MC scaffold indicating its excellent *** adult sheep cranial bone defect model was constructed to evaluate the performances of these cranioplasty materials in repairing the cranial bone *** results were investigated by gross observation,computed tomography scanning as well as histological *** in vivo evaluations indicated that compact MC scaffold showed notable osteoconductivity and osseointegration with surrounding cranial bone tissues by promoting bone *** results suggested that the compact MC scaffold has a promising potential for large-sized cranial bone defect repair.

关键词： mineralized collagen cranial bone defect bone regeneration sheep cranioplasty materials

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