检索结果-南通市图书馆

Laccase-catalysed semisynthesis of urushiol coumarin derivatives and their anticancer activity

在线全文

学校读者我要写书评

暂无评论

Laccase-catalysed semisynthesis of urushiol coumarin derivat...

Synthesis,Crystal Structure and Photoluminescence of Ethyl coumarin-3-carboxylate derivatives

中国化学会第十二届全国天然有机化学学术会议

作者： Zhiwen Qi Chengzhang Wang Jianxin Jiang Institute of Chemical Industry of Forest Products CAF Key and Open Laboratory on Forest Chemical Engineering SFA College of Material Science and Technology Beijing Forestry University

Lacquer laccase coexists with lacquer urushiol in Toxicodendron vernicifluum（Stokes）.And T1 Cu location redox potential of it is lower than that of some laccase from bacterial colony,just reaching 430 mV. Laccase catalysis reaction is generally realized by oxidizing to free radicals which are reoxidized to large volume or substrate molecules with high redox potential *** as novel antitumor ingredients,urushiol easily converts to coumarin derivatives which show human carbonic anhydrase（hCA） inhibitory *** hCA inhibition is one of the underlying mechanisms that account for the activities of some antiepileptic drugs（AEDs）,it’s expected to have anti-seizure ***,we designed as well as synthesized a series of novel C15 triene urushiol derivatives,and the results indicated that they are effective in inhibiting HepG2 ***,we first analyzed the probable binding-modes of the most active compound by molecular docking algorithms,and calculated their enzymatic bioactivity against ***,some derivatives can excellently reduce the hCA expression.

关键词： urushiol redox potential coumarin derivatives antitumor hCA

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2014年第1期33卷 57-64页

作者：宋立美高建华 School of Chemistry and Chemical Engineering Xi’an University of Arts and Science Department of Physics Northwest University

The ethyl coumarin-3-carboxylate （1） and its two derivatives, ethyl 7-methoxy-2- oxo-2H-chromene-3-carboxylate （2） and ethyl 7-（3-methylbut-2-enyloxy）-2-oxo-2H-chromene-3- carboxylate（3）, were synthesized, characterized and their UV-vis spectra and photoluminescence were investigated. Compound 2 crystallizes in the monoclinic system with space group C2/c, a = 25.884（4）, b = 6.8365（11）, c = 13.816（2） A, β = 104.876（2）°, V= 2362.9（7） A3, Z = 8, Dc= 1.396 g/cm3, Mr. = 248.23, F（000） = 1040 and g = 0.108 mm-1. Compound 3 crystallizes in the monoclinic system with space group P21/c, a = 15.685（6）, b = 8.373（3）, c = i3.063（5） A, β = 111.862（6）°, V= 1592.2（10） A3, Z = 4, Dc = 1.261 g/cm3, M,.= 302.31, F（000） = 640 and p = 0.093 mm^-1. Both the absorption and emission of the two derivatives were stronger than that of ethyl coumarin-3-carboxylate due to the larger conjugation of their electron donor group moiety at the 7-position. Under ultraviolet light excitation, the two derivatives exhibit strong blue-violet emission.

关键词： coumarin derivatives crystal structure UV-vis spectrum photoluminescence

Chemical behaviours of 3-[1'-chloro-3'-(2"-phenyl-1",3"-oxazol-5"-one-4"-ylidene)propen-l'-yl]coumarin towards some nucleophilic reagents

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 1998年第6期16卷 533-537页

作者： EL-DEEN Ibrahim Mohey Faculty of Education Suez Canal University Port-Said EgyptFaculty of Education Suez Canal University Port-Said Egypt

The chemical behaviours of 3-[1'-chloro-3'-(2'-phenyl-1',3'-oxazol-5'-one-4'-ylidene)-propen-1'-yl]coumarin towards nucleophilic reagents (such as hydrolysis,aminolysis,hydroxyl-aminolysis,methanolysis and hydrazinoly... 详细信息

关键词： Chemical behaviours coumarin derivatives nucleophiles

Synthesis,Crystal Structure and Characterization of3-Ethyl-3,4,4a,10a-tetrahydro-2H-1,5-dioxa-3-aza-phenanthren-6-one:C_(13)H_(13)NO_3

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2013年第10期32卷 1503-1508页

作者：黄金李胜刘鹏傅佳骏王瑛 School of Chemical Engineering Nanjing University of Science and Technology

3-Ethyl-3,4,4a, 10a-tetrahydro-2H- 1,5-dioxa-3-aza-phenanthren-6-one （C13H13NO3, Mr = 231.24） was synthesized and characterized by FT-IR, H NMR spectra, and thermal analysis. The crystal structure was determined by X-ray single-crystal diffraction. It crystallizes in methanol. The crystal is of orthorhombic system, space group Pbca with a = 8.9250（18）, b = 12.605（3）, c = 20.552（4） A, Z = 8, V = 2312.1（8） A3, Dc = 1.329 mg/m3, p = 0.095 mm-, F（000） = 976, R = 0.0583 and wR = 0.1340. Thermal analysis reveals that it is stable below 100 C. Fluorescence spectra analysis shows that its fluorescence intensity is twice as that of 7-hydroxylcoumarin in methanol solution with the same concentration.

关键词： crystal growth fluorescence coumarin derivatives bezoxazine

Synthesis and Crystal Structure of 8-Methyl-7-(3-nitrophenyl)-10-phenyl-10,11-dihydrochro-meno[4,3-b]pyrazolo[4,3-e]pyridin-6-(7H)-one

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2012年第1期31卷 57-60页

作者：林志兰游新奎张雪利高原 College of Chemistry and Chemical Engineering Shenzhen University

The title compound（C26H18N4O4） has been synthesized via a three-component reaction and it was characterized by means of IR and 1H *** crystal and molecular structures were determined by X-ray *** belongs to the triclinic system,space group P1 with a = 7.7288（15）,b = 11.168（2）,c = 12.645（3） ,α = 107.02（3）,β = 90.85（3）,γ = 101.93（3）°,V = 1017.9（3） 3,Mr = 450.44,Z = 2,Dc = 1.470 g/cm3,λ = 1.54178 ,μ = 0.836 mm-1,F（000） = 468,the final R = 0.0488 and wR = 0.1180.A total of 11903 reflections were collected,of which 3642 were independent（Rint = 0.0377） and 3025 were observed with I 2σ（I）.

关键词： multicomponent reaction coumarin derivatives crystal structure