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A precision medicine approach to managing 2019 novel coronavirus pneumonia

Precision Clinical Medicine 2020年第1期3卷 14-21页

作者： Minjin Wang Yanbing Zhou Zhiyong Zong Zongan Liang Yu Cao Hong Tang Bin Song Zixing Huang Yan Kang Ping Feng Binwu Ying Weimin Li Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041China Center of Infectious Diseases West China HospitalSichuan UniversityChengdu 610041China Department of Respiratory and Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041China Department of Emergency Medicine West China HospitalSichuan UniversityChengdu 610041China Department of Radiology West China HospitalSichuan UniversityChengdu 610041China Department of Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041China

In December 2019,several patients with pneumonia of an unknown cause were detected in Wuhan,China.On 7 January 2020,the causal organism was identified as a new coronavirus,later named as the 2019 novel coronavirus(2019-nCoV).Genome sequencing found the genetic sequence of 2019-nCoV homologous to that of severe acute respiratory syndrome-associated coronavirus.As of 29 January 2020,the virus had been diagnosed in more than 7000 patients in China and 77 patients in other countries.It is reported that both symptomatic and asymptomatic patients with 2019-nCoV can play a role in disease transmission via airborne and contact.This finding has caused a great concern about the prevention of illness spread.The clinical features of the infection are not specific and are often indistinguishable from those of other respiratory infections,making it difficult to diagnose.Given that the virus has a strong ability to spread between individuals,it is of top priority to identify potential or suspected patients as soon as possible—or the virus may cause a serious pandemic.Therefore,a precision medicine approach to managing this disease is urgently needed for detecting and controlling the spread of the virus.In this article,we present such an approach to managing 2019-nCoV-related pneumonia based on the unique traits of the virus recently revealed and on our experience with coronaviruses at West China Hospital in Chengdu,China.

关键词： 2019-nCoV COVID-19∗ coronavirus pneumonia SARS MERS epidemic pandemic precision medicine

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Current Global Status and Future Development of Traditional Chinese Medicine in the Prevention and Treatment of coronavirus Disease 2019

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World Journal of Traditional Chinese Medicine 2021年第2期7卷 155-166页

作者： Ze-Jia Song Wan Najbah Nik Nabil Zhi-Chao Xi Hong-Xi Xu School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghaiChina Pharmaceutical Services Program Ministry of HealthPetaling JayaMalaysia Shuguang Hospital Shanghai University of Traditional Chinese MedicineShanghaiChina

Recognizing the potential of globalizing traditional Chinese medicine(TCM)for coronavirus disease 2019(COVID-19),this review summarizes the current global use of TCM for COVID-19,status of the internationalization of TCM,and strategy on globalizing TCM for COVID-19.COVID-19 is a novel coronavirus disease that has sparked a pandemic in March 2020 affecting over 110 countries.Although researchers have been racing to develop targeted anti-COVID-19 treatment and vaccine,they are still currently unavailable.Thus,in treating patients infected with COVID-19,western medicine mainly recommended symptomatic treatment and monitoring.Existing drugs are used in the context of clinical trials,and the FDA still not yet approved these drugs for COVID-19.On the other hand,TCM proposed herbal treatment for suspected individuals to take within their observation period,as well as for confirmed COVID-19 patients to take during active phase of disease and during recovery.In China,Integrative Chinese-Western Medicine had been used in treating 91.5%of COVID-19 patients and showed its strength in reducing disease severity,shortening recovery time,and lowering the mortality rate.Despite obstacles in globalizing TCM for the treatment of COVID-19,promoting appropriate use of locally registered TCM products may prevent disease in susceptible individuals,improve the quality of life,and assist in the recovery of COVID-19 patients.With increasing global acceptance,TCM may play a more important role in the battle against infectious disease in the future.

关键词： coronavirus disease 2019 coronavirus pneumonia traditional Chinese medicine traditional Chinese medicine globalization

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Comparative Study of Traditional Chinese Medicine and Western Medicine in the Treatment of coronavirus

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Chinese Medicine and Culture 2020年第4期3卷 201-204页

作者： Li Shen Ke Wang Jia Zhou Publicity Department Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina Acupuncture Anesthesia Clinical Research Institute Department of Cardiothoracic Surgery Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Taking the process of treating coronavirus disease 2019(COVID-19)with Western medicine and traditional Chinese medicine(TCM)as the research object,this article compares the characteristics of Western medicine and TCM from the perspectives of aetiology,pathogenesis,diagnosis,and treatment.Western medicine and TCM each has its own theoretical system.Each has its own exposition in explaining the etiology and pathogenesis of the disease,and each has its own characteristics and advantages in diagnosis and treatment.Integrating TCM and Western medicine can improve the effect of treatment by forming a coordinated traditional Chinese and Western medicine treatment method.

关键词： Combination of Chinese and Western medicine comparative study coronavirus pneumonia COVID-19

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