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corneal subepithelial nerve fibers in type 2 diabetes:potential biomarker of diabetic neuropathy

International Journal of Ophthalmology(English edition) 2024年第11期17卷 2060-2066页

作者： Ling-Rui Meng Hua Chen Wen-Qian Chen Yi Gao Zi-Wei Li Zi Ye Zhao-Hui Li Senior Department of Ophthalmology the Third Medical CenterChinese PLA General HospitalBeijing 100039China Medical School of Chinese PLA Beijing 100853China

AIM:To observe the changes in corneal subepithelial nerve fibers(CNFs)and Langerhans cells(LCs)in patients with type 2 diabetes using corneal laser confocal microscopy(CLCM).METHODS:A total of 60 patients(64 eyes),including 40 patients with type 2 diabetes(DM group)and 20 subjects without diabetes(control group)were included with *** J plugin of Image J software were used for quantitative analysis of CNF length(CNFL),CNF density(CNFD),corneal nerve branch fiber density(CNBD),main branch length density,branch length density,corneal nerve fiber tortuosity(NT)score,and LCs *** independent samples t-test to analyze the variability between the two groups was performed,and Pearson correlation analysis was used to analyze the relationships between CNF and multiple biochemical indicators in the DM *** predictive power of CNF for type 2 diabetes was assessed using the receiver operating characteristic(ROC)***:There were significant differences in the CNFL,CNFD,and main branch length density between two *** results of Pearson correlation analysis showed a significant negative correlation between CNFD and the duration of diabetes as well as triglyceride levels and total cholesterol,and a significant positive correlation between CNFD and serum *** addition,the NT score showed a positive correlation and urea nitrogen,similar to the positive correlation observed between LC density and glycosylated hemoglobin(HbA1c)*** showed the highest area under the curve(AUC of ROC)value,followed by main branch length density and *** AUC of the ROC curve under the logistic regression model also demonstrated good predictive *** cut-off values of CNFD,CNFL,and main branch length density for diabetes showed 31.25,18.85,and 12.56,***:In patients with type 2 diabetes,there is a notable reduction in both CNFL and *** measurements can be influenced by various blood biochemical ***,the compromised n

关键词： corneal subepithelial nerve diabetes glycated hemoglobin Langerhans cells diabetic neuropathy

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