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MCSTransWnet:A new deep learning process for postoperative corneal topography prediction based on raw multimodal data from the Pentacam HR system

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Medicine in Novel Technology and Devices 2024年第1期21卷 53-63页

作者： Nan Cheng Zhe Zhang Jing Pan Xiao-Na Li Wei-Yi Chen Guang-Hua Zhang Wei-Hua Yang College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030600ShanxiChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040GuangdongChina Department of Intelligence and Automation Taiyuan UniversityTaiyuan 030032ShanxiChina Graphics and Imaging Laboratory University of GironaGirona 17004Spain

This work provides a new multimodal fusion generative adversarial net(GAN)model,Multiple Conditions Transform W-net(MCSTransWnet),which primarily uses femtosecond laser arcuate keratotomy surgical parameters and preoperative corneal topography to predict postoperative corneal topography in astigmatism-corrected *** MCSTransWnet model comprises a generator and a discriminator,and the generator is composed of two *** first sub-generator extracts features using the U-net model,vision transform(ViT)and a multi-parameter conditional module branch.The second sub-generator uses a U-net network for further image *** discriminator uses the pixel discriminator in ***,most GAN models are convolutional neural networks;however,due to their feature extraction locality,it is difficult to comprehend the relationships among global ***,we added a vision Transform network as the model branch to extract the global *** is normally difficult to train the transformer,and image noise and geometric information loss are ***,we adopted the standard U-net fusion scheme and transform network as the generator,so that global features,local features,and rich image details could be obtained *** experimental results clearly demonstrate that MCSTransWnet successfully predicts postoperative corneal topographies(structural similarity=0.765,peak signal-to-noise ratio=16.012,and Fréchet inception distance=9.264).Using this technique to obtain the rough shape of the postoperative corneal topography in advance gives clinicians more references and guides changes to surgical planning and improves the success rate of surgery.

关键词： Deep learning Generative adversarial networks corneal topography Transformer W-net U-net Medical imaging Multimodal fusion

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Validity of autorefractor based screening method for irregular astigmatism compared to the corneal topography-a cross sectional study

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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1412-1418页

作者： Alicia Galindo-Ferreiro Julita De Miguel-Gutierrez Manuel González-Sagrado Alberto Galvez-Ruiz Rajiv Khandekar Silvana Schellini Julio Galindo-Alonso King Khaled Eye Specialist Hospital Riyadh 12329SaudiArabia Department of Ophthalmology Rio-Hortega University HospitalValladolid 47012Spain Unit Research Support Rio-Hortega HospitalValladolid 47012Spain Faculdade de Medicina de Botucatu State University of SgoPauloUNESP 18618687Brazil Galindo Clinic Valladolid 47003Spain

AIM：To present a method of screening for irregular astigmatism with an autorefractor and its determinants compared to corneal ***：This cross-sectional validity study was conducted in 2013 at an eye hospital in Spain.A tabletop autorefractor（test 1）was used to measure the refractive status of the anterior surface of the cornea at two corneal meridians of each *** corneal topography（test 2）and Bogan’s classification was used to group eyes into those with regular or no astigmatism（GRI）and irregular astigmatism（GRII）.Test 1 provided a single absolute value for the greatest cylinder difference（Vr）.The receiver operating characteristic（ROC）were plotted for the Vr values measured by test 1 for GRI and GRII *** the basis a Vr value of 1.25 D as cut off,sensitivity,specificity were also ***：The study sample was comprised of 260 eyes（135 patients）.The prevalence of irregular astigmatism was 42%[95%confidence interval（CI）：36,48].Based on test 2,there were 151 eyes in GRI and 109 eyes in *** median Vr was 0.75 D（25%quartile,0.5 D）for GRI and1.75 D（25%quartile,1.25 D）for *** area under curve was 0.171 for GRI and 0.83 for *** sensitivity of test I was 78.1%and the specificity was 76.1%.CONCLUSION：A conventional autorefractor can be effective as a first level screening method to detect irregular corneal astigmatism in places where corneal topography facilities are not available.

关键词： screening irregular astigmatism autorefrac-tot corneal topography cornea validity

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Using LaserSight Astrapro Planner 2.2 Z software in corneal topography-guided laser in situ keratomileusis for myopia with asymmetric corneal shape

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International Journal of Ophthalmology(English edition) 2014年第3期7卷 452-456页

作者： Bing Liu Wei Chen De-Wang Shao Hua Wang Hai-Xia Ru Min Zhang Ying Wang Chun-Yan Yang Department of Ophthalmology Air Force General Hospital of PLA

AIM:To determine the clinical outcomes of laser insitu keratomileusis(LASIK)treatments using LaserSight AstraPro Planner 2.2 Z software for myopia with asymmetric corneal ***:Four hundred and eighty-five eyes[243patients;spherical equivalent(SE),-5.93±1.88 diopters(D)]were treated with asymmetric ablations using LaserSight SLX laser(version 5.3,300Hz)were retrospectively analyzed and LaserSight AstraPro Planner2.2 Z *** and postoperative uncorrected visual acuities(UCVA),spherical equivalent(SE)refraction,pachymetry,and corneal asphericity(Q value)and decentration were ***:At 12mo postoperatively,the decimal UCVA was 1.0 or better in 449(92.6%)*** eyes(0.4%)lost 1 line of the decimal best spectacle-corrected visual acuity(BCVA),316(65.2%)did not change,149(30.7%)gained 1 line,and 18(3.7%)gained 2 lines or more after *** hundred and thirty-two eyes(68.5%)were within 0.5 D in *** mean tissue saving ablation depth was 4.28±2.86(0-16)μm(median,4μm).The mean attempted remaining central corneal thickness was435.79±29.56μm,the mean postoperative pachymetry was 444.94±28.93μ*** mean preoperative Q value was-0.19±0.18,the postoperative was 0.30±0.48(P=0.000).The mean postoperative decentration was 0.39±0.19 ***:topography-guidedLASIKwithAstraPro Planner 2.2 Z custom ablation planning software in an asymmetric ablation mode was an effective,safe,predictable,and stable refractive procedure for the myopia with asymmetric corneal topography.

关键词： myopia laser in situ keratomileusis corneal topography asymmetric ablation

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Influence of overnight orthokeratology lens fitting decentration on corneal topography reshaping

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Eye and Vision 2018年第1期5卷 48-58页

作者： Jiaojie Chen Wei Huang Rong Zhu Jun Jiang Yiyu Li School of Optometry and Ophthalmology WenZhou Medical UniversityWenZhouZheJiangChina Eye Hospital of Wenzhou Medical University 270 West Xueyuan RoadWenzhouZhejiang 325027China

Background:This retrospective study was designed to investigate the sole influence of orthokeratology(OK)lens fitting decentration on the Zernike coefficients of the reshaped anterior corneal ***:This study comprised a review of 106 right eyes and measurements of corneal topography both before OK and at 1-month follow-up visit.A routine was designed to calculate local corneal surface astigmatism and assist the determination of OK lens fitting decentration from pupil *** pupil-centered corneal Zernike coefficients of baseline(PCCB)and post-treatment(PCCP)were ***,the OK-lens-centered corneal Zernike coefficients of post-treatment(OCCP)were also calculated and considered as the presumptive ideal fitting group without *** between lens fitting decentration and the change of Zernike coefficients including(PCCP−PCCB)and(PCCP−OCCP)were ***:Patients with a mean age of 11±2.36 years old had an average spherical equivalent refractive error of−3.52±1.06 D before *** month after treatment,OK lens fitting decentration from pupil center was 0.68±0.35 *** of 3rd-order(Pcorneal Zernike coefficients were increased in PCCP by comparing with OCCP,which was solely caused by lens fitting ***,no significant difference was observed in C^(0)_(2)(P>0.05).For the high order corneal Zernike coefficients in(PCCP–OCCP),radial distance of decentration was correlated with C^(−1)_(3)(r=−0.296,Pcorneal spherical power for myopia correction,but significantly induced additional corneal

关键词： Orthokeratology Lens fitting decentration Zernike coefficients Contact lens corneal topography

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Accuracy and reliability of orthogonal polynomials in representing corneal topography

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Medicine in Novel Technology and Devices 2022年第3期15卷 124-133页

作者： Junjie Wang Xuefei Li Zheng Wang Pinakin G.Davey Yiyu Li Lanting Yang Mao Lin Xiaobo Zheng Fangjun Bao Ahmed Elsheikh Eye Hospital Wenzhou Medical UniversityWenzhouChina The Institution of Ocular Biomechanics Wenzhou Medical UniversityWenzhouChina College of Optometry Western University of Health SciencesPomonaCAUSA School of Engineering University of LiverpoolLiverpoolUK National Institute for Health Research(NIHR)Biomedical Research Centre for Ophthalmology Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of OphthalmologyLondonUK Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijingChina No.270 Xueyuan West Road Wenzhou CityZhejiang Province325027China

Fitting of corneal topography data to analytical surfaces has been necessary in many clinical and experimental applications,yet absolute superiority of fitting methods was still unclear,and their overfitting risks were not well *** study aimed to evaluate the accuracy and reliability of orthogonal polynomials as fitting routines to represent corneal *** orthogonal polynomials,namely,Zernike polynomials(ZPs),pseudo-Zernike polynomials(PZPs),Gaussian-Hermite polynomials(GHPs)and Orthogonal Fourier-Mellin polynomials(OFMPs),were employed to fit anterior and posterior corneal topographies collected from 200 healthy and 174 keratoconic eyes using Pentacam *** fitting performance of these polynomials were compared,and the potential overfitting risks were assessed through a prediction *** results showed that,except for low orders,the fitting performance differed little among polynomials with orders10 regarding surface reconstruction(RMSEs~0.3μm).Anterior surfaces of normal corneas were fitted more efficiently,followed by those of keratoconic corneas,then posterior corneal *** results,however,revealed an alarming fact that all polynomials tended to overfit the data beyond certain ***,closely followed by ZPs,were the most robust in predicting unmeasured surface locations;while PZPs and especially OFMPs overfitted the surfaces *** 10 appeared to be optimum for corneal surfaces with 10-mm diameter,ensuring accurate reconstruction and avoiding *** optimum order however varied with topography diameters and data *** study concluded that continuing to use ZPs as fitting routine for most topography maps,or using GHPs instead,remains a good *** polynomial orders close to the topography diameters(millimeters)is generally suggested to ensure both reconstruction accuracy and prediction reliability and avoid overfitting for both normal and complex(e.g.,keratoconic)corneal surfac

关键词： corneal topography Orthogonal polynomials Optimum order Overfitting Pentacam

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Visual differences in topography-guided versus wavefront-optimized LASIK in the treatment of myopia: a Meta-analysis

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International Journal of Ophthalmology(English edition) 2021年第10期14卷 1602-1609页

作者： Peng-Cheng Hu Li Li Xian-Hui Wu Yan-Qing Li Ke-Wei Li Department of Ophthalmology the Second Affiliated Hospital of Chongqing Medical UniversityChongqing Medical UniversityChongqing 400010China Department of Ophthalmology the First Affiliated Hospital of Chongqing Medical UniversityChongqing Medical UniversityChongqing 400016China

AIM: To investigate the potential differences between topography-guided(TG) and wavefront-optimized(WFO) laser in situ keratomileusis(LASIK) for the treatment of ***: A systematic literature search was performed to determine relevant trials comparing LASIK with TG and WFO from the time of library construction to August 2020, and The PubMed, Cochrane, Web of Science, EMBASE and Chinese databases(i.e. CNKI, CBM, WAN FANG and VIP) were accessed. The data on visual acuity, refractive status and wavefront aberration were retrieved and evaluated from three to six months after surgery. STATA(version 14.0) software was used for statistical analysis. A cumulative Meta-analysis was simultaneously ***: Eleven studies with a total of 1425 eyes were incorporated. No statistically significant differences were evident between TG and WFO ablation in the proportion of eyes achieving an uncorrected distance visual acuity(UCVA) of 20/20 or better(P=0.377), gaining one line or more(P=0.05), postoperative cylinder(P=0.40), vertical coma(P=0.593) and horizontal coma(P=0.957). After TG ablation, the proportion of the patients’ eyes of which postoperative refraction is within ±0.5 diopter of the target refraction was significantly higher than that undergoes WFO(P=0.003). As opposed to the WFO group, manifest refraction spherical equivalent(MRSE;P=0.000) was lower, and UCVA(P=0.005) was better in the TG group. The higher-order aberrations(HOAs;P=0.000), spherical aberration(P=0.000) and coma(P=0.000) were significantly lower in TG group. The cumulative Meta-analysis illustrated that the proportion of eyes achieving UCVA of 20/20 or better, postoperative refraction within ±0.5 diopter, and MRSE has steady between the two ***: Both TG-LASIK and WFO-LASIK are safe, effective, and predictable for correcting myopia. TG-LASIK may produce fewer aberration and is more precise than WFO-LASIK.

关键词： Meta-analysis corneal topography wavefront aberration laser in situ keratomileusis myopia

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Comparison of corneal biological parameters between transepithelial and epithelium-off corneal cross-linking in keratoconus

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International Journal of Ophthalmology(English edition) 2021年第7期14卷 998-1005页

作者： Bo-Wen Ouyang Hui Ding Han Wang Zhen-Duo Yang Tan Zhong Hong-Ming Fan Xing-Wu Zhong Zhongshan Ophthalmic Center State Key Laboratory of OphthalmologySun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina Hainan Eye Hospital Zhongshan Ophthalmic CenterSun Yat-sen UniversityHaikou 570311Hainan ProvinceChina

AIM:To evaluate the differences in corneal biological parameters between transepithelial and epithelium-off corneal cross-linking in ***:In our prospective clinical trial,40 patients(60 eyes)with progressive keratoconus were randomized to undergo corneal cross-linking with transepithelial(TE group,n=30)or epithelium-off(EO group,n=30)*** comprised topography,corneal biomechanical analysis and specular microscopy at 6 mo ***:The keratometer values were not significantly different between the TE and EO corneal cross-linked groups in different periods(each P>0.05).The corneal thickness of the EO group was greater than that of the TE group at 1 wk after the operation(each Pcorneal biomechanical responses,the EO group showed a longer second applanation length than TE group(P=0.003).Regarding the corneal endothelial function,standard deviation of the endothelial cell size,and coefficient of variation in the cell area,the values of EO group were larger than those of TE group at 1 wk(P=0.011,0.026),and the percentage of hexagonal cells in EO group was lower than that in TE group at 1 and 6 mo(P=0.018,0.019).CONCLUSION:Epithelium-off corneal cross-linking may strengthen corneal biomechanics better than TE procedure ***,the TE procedure with a lower ultraviolet-A irradiation intensity would be safer for corneal endothelial function.

关键词： keratoconus corneal cross-linking transepithelial epithelium-off corneal biomechanics corneal topography

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Three-year follow-up in advanced pediatric keratoconus:thin corneas may not have pachymetry properly assessed after crosslinking

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International Journal of Ophthalmology(English edition) 2020年第10期13卷 1561-1566页

作者： Rosalia Antunes-Foschini Sidney Júlio Faria-e-Sousa Hospital das Clínicas Medical School of Ribeirao PretoUniversity of Sao PauloRibeirao Preto 14049-900Brazil Department of Ophthalmology OtorhinolaryngologyHead and Neck SurgeryMedical School of Ribeirao PretoUniversity of Sao PauloRibeirao Preto 14049-900Brazil

AIM:To analyze the crosslinking(CXL)effects in pediatric keratoconus,and to identify the patients’corneal characteristics whose pachymetry could not be adequately evaluated by Scheimpflug method after ***:Consecutive pediatric patients with progressive keratoconus underwent CXL were ***-corrected visual acuity(BCVA)and spheric equivalent(SE)were measured before and after *** CXL,groups 1 and 2 were divided based on the posterior surface Pentacam quality specifications(QS):"OK"(Group 1)and"not OK"(Group 2).The mean(RmF and RmB)and minimum(RminF and RminB)radius of curvatures of the anterior and posterior corneal surfaces,and the thinnest pachymetry(Pmin)were measured preoperatively at 3,6,12,24,and 36 *** was ***:Twenty-six patients(14 men,mean age 14±1.8 y)and median Kmax of 59.9 D initially and 61.4 D preoperatively were *** was not different before and 24 mo after *** 2 statistically differed to group 1 in that SE was more myopic before and with no difference 24 mo after CXL;RmF and RmB were steeper and Pmin was thinner *** 2,in which pachymetric changes could not be adequately evaluated after surgery,presented with significant RmF flattening,a shift to hyperopia,and more haze after ***:Patients whose pachymetry could not be adequately evaluated after CXL had steeper and thinner corneas before *** predictive factors for impaired QS after CXL are RmF,RmB,and *** advanced keratoconus,alternative methods to analyze pachymetry and the posterior surface should be considered.

关键词： keratoconus cross-linking corneal pachymetry corneal topography corneal opacity

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Interchangeability of corneal curvature and asphericity measurements provided by three different devices

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 412-416页

作者： David P.Pinero Roberto Soto-Negro Pedro Ruiz-Fortes Rafael J Pérez-Cambrodí Hideki Fukumitsu Department of Optics Pharmacology and AnatomyUniversity of AlicanteSan Vicente del Raspeig 03690 Department of Ophthalmology(OFTALMAR) Vithas Medimar International Hospital Department of Ophthalmology Marina Baixa Hospital

AIM: To evaluate the interchangeability of keratometric and asphericity measurements provided by three measurement systems based on different optical ***: A total of 40 eyes of 40 patients with a mean age of 34.1 y were included. In all cases, a corneal curvature analysis was performed with IOL-Master(IOLM), iDesign 2(ID2), and Sirius systems(SIR). Differences between instruments for flattest(K1) and steepest(K2) keratometric readings, as well as for magnitude and axis of corneal astigmatism were analyzed. Likewise, differences in asphericity(Q) between SIR and ID2 were also evaluated. RESULTS: Mean differences between devices for K1 were 0.20±0.21(Pcorneal power, astigmatic axis and asphericity measurements provideby the three systems evaluated cannot be considered as interchangeable, whereas measurements of corneal astigmatism obtained with SIR and ID2 can be considered as interchangeable for clinical purposes.

关键词： astigmatism corneal topography keratometry corneal asphericity

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Early visual function outcomes of topography-guided FS-LASIK and SMILE in treatment of myopia and myopic astigmatism

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International Journal of Ophthalmology(English edition) 2021年第3期14卷 423-429页

作者： Lin-Juan Yang Xuan Liu Sheng-Jian Mi Le Sun Meng-Xin Chen Department of Ophthalmology the First Affliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina

AIM: To compare the quality outcomes of vision at early phase after topography-guided femtosecond laser-assisted in situ keratomileusis(FS-LASIK-CV) and small incision lenticule extraction(SMILE) in treatment of myopia and myopic ***: Retrospective comparative analysis of 49 patients that underwent FS-LASIK(n=23) or SMILE(n=26) procedure for myopia and myopic astigmatism between April and September in 2019. Pre-and postoperative uncorrected visual acuity(UCVA), spherical equivalent refraction(SEQ), cylindrical refraction, contrast sensitivity function(CSF), and corneal higher-order aberrations(HOAs) were evaluated. Independent t-test was used for inter-group comparison, while repeated measures ANOVA was used to analyze changes at different time points. RESULTS: In both groups, 100% of the eyes obtained a UCVA of 20/20 or better at 1 wk, 1, and 3 mo postoperatively. At 1 d and 3 mo postoperatively, UCVA was better in FS-LASIKCV group than in SMILE group. At 1 wk postoperatively, SEQ was lower in SMILE group than in FS-LASIK-CV group(P=0.006). At 3 mo postoperatively, the SEQ reached target refraction in both groups. The residual astigmatism was reduced in both groups without intergroup difference(P>0.05). At 3 mo postoperatively, the spherical aberration and coma under 6 mm pupil size were higher than preoperative levels in both groups(Pcorneal HOAs in the FS-LASIK-CV group was less than the SMILE group(P<0.05). At 3 mo postoperatively, the log CS were better than preoperative levels under scotopic conditions without glare and scotopic conditions with glare in both groups(P<0.05). At 1 and 3 mo postoperatively, under scotopic conditions without glare and scotopic conditions with glare, FS-LASIK-CV group showed more improvement in log CS at two spatial frequencies(12.0 c/d and 18.0 c/d;P<0.05).CONCLUSION: Both FS-LASIK-CV and SMILE demonstrate to be safe, effective, and predictable in treatment of myopia and myopic

关键词： corneal topography femtosecond laser laser-assisted in-situ keratomileusis small incision lenticule extraction quality of vision contrast sensitivity

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