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3D-printed gelatin methacrylate (GelMA)/ silanated silica scaffold assisted by two-stage cooling system for hard tissue regeneration

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Regenerative Biomaterials 2021年第2期8卷 50-63页

作者： Eunjeong Choi Dongyun Kim Donggu Kang Gi Hoon Yang Bongsu Jung MyungGu Yeo Min-Jeong Park SangHyun An KyoungHo Lee Jun Sik Kim Jong Chul Kim Woonhyeok Jeong Hye Hyun Yoo Hojun Jeon Research Institute of Additive Manufacturing and Regenerative Medicine Baobab Healthcare Inc55 Hanyangdaehak-RoAnsanGyeonggi-do 15588South Korea Department of Mechanical Engineering Korea Polytechnic UniversitySangidaehak-roSiheungGyeonggi-do 15073South Korea Medical Device Development Center Daegu-Gyeongbuk Medical Innovation Foundation(DGMIF)80Cheombok-roDong-guDaegu 41061South Korea Laboratory Animal Center Daegu-Gyeongbuk Medical Innovation Foundation(DGMIF)80 Cheombok-roDong-guDaegu 41061South Korea Department of Plastic and Reconstructive Surgery Dongsan Medical CenterKeimyung University College of Medicine1035 Dalgubeol-daeroDalseo-guDaegu 42601South Korea Institute of Pharmaceutical Science and Technology College of PharmacyHanyang University55 Hanyangdaehak-RoAnsanGyeonggi-Do 15588South Korea

Among many biomaterials,gelatin methacrylate(GelMA),a photocurable protein,has been widely used in 3D bioprinting process owing to its excellent cellular responses,biocompatibility and biodegradability.However,GelMA still shows a low processability due to the severe temperature dependence of viscosity.To overcome this obstacle,we propose a two-stage temperature control system to effectively control the viscosity of GelMA.To optimize the process conditions,we evaluated the temperature of the cooling system(jacket and stage).Using the established system,three GelMA scaffolds were fabricated in which different concentrations(0,3 and 10 wt%)of silanated silica particles were embedded.To evaluate the performances of the prepared scaffolds suitable for hard tissue regeneration,we analyzed the physical(viscoelasticity,surface roughness,compressive modulus and wettability)and biological(human mesenchymal stem cells growth,western blotting and osteogenic differentiation)properties.Consequently,the composite scaffold with greater silica contents(10 wt%)showed enhanced physical and biological performances including mechanical strength,cell initial attachment,cell proliferation and osteogenic differentiation compared with those of the controls.Our results indicate that the GelMA/silanated silica composite scaffold can be potentially used for hard tissue regeneration.

关键词： 3D bioprinting gelatin methacrylate silanated silica cooling system human mesenchymal stem cells

Simulation Analysis of New Energy Vehicle Engine cooling system Based on K-E Turbulent Flow Mathematical Model

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Energy Engineering 2023年第10期120卷 2325-2342页

作者： Hongyu Mu Yinyan Wang Chuanlei Yang Hong Teng Xingtian Zhao Hongquan Lu Dechun Wang Shiyang Hao Xiaolong Zhang Yan Jin College of Power and Energy Engineering Harbin Engineering UniversityHarbin150001China Extended Range Power system Research Institute Harbin Dongan Auto Engine Co.Ltd.Harbin150000China

New energy vehicles have better clean and environmental protection characteristics than traditional fuel vehicles.The new energy engine cooling technology is critical in the design of new energy vehicles.This paper used oneand three-way joint simulation methods to simulate the refrigeration system of new energy vehicles.Firstly,a k-εturbulent flow model for the cooling pump flow field is established based on the principle of computational fluid dynamics.Then,the CFD commercial fluid analysis software FLUENT is used to simulate the flow field of the cooling pump under different inlet flow conditions.This paper proposes an optimization scheme for new energy vehicle engines’“boiling”phenomenon under high temperatures and long-time climbing conditions.The simulation results show that changing the radiator’s structure and adjusting the thermostat’s parameters can solve the problem of a“boiling pot.”The optimized new energy vehicle engine can maintain a better operating temperature range.The algorithm model can reference each cryogenic system component hardware selection and control strategy in the new energy vehicle’s engine.

关键词： New energy vehicle new energy vehicle engine k-ε turbulent flow mathematical model cooling system PID control

Intelligent Scheduling for High Bulilding Multi-type cooling system

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Journal of Donghua University(English Edition) 2014年第2期31卷 179-183页

作者：刘楚晖郑毅蔡旭陈烈 School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai Jiankun Information Technology Co . Ltd

In modern giant buildings,in order to improve energy utilization efficiency, cooling systems have developed from conventional chillers alone to smart energy net which includes chillers,ice storage,ground-source heat pump,combined cooling heating and power( CCHP) and so on. The reasonable distribution of load is the key to guarantee such system in economical operation.Based on typical multi-type cooling system,economic models of different devices are presented and real-time intelligent economic scheduling with the approach of mixed integer programming is carried out. This algorithm has been applied in a certain building of Shanghai and results of simulation show that it is able to provide guidance on intelligent economic scheduling for multi-type cooling system.

关键词： cooling system ice storage intelligent economic scheduling mixed integer programming

FSAE Aerodynamic Design Based on the Rear Layout of the Radiator and Targeted Improvement of the cooling system

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FSAE Aerodynamic Design Based on the Rear Layout of the Radi...

2021中国汽车工程学会年会暨展览会

作者： Wang Da Zhou Fuqiu Gu Leqi Huang Yuanxin Shan Yuchen Yang Mingjia Wang Miaoxin Zhang Yuqi College of Automotive Engineering Jilin University

Taking the Formula Student racing car as the research object,and taking Jilin University Gspeed Formula Racing Team’s racing cars as examples,while using the new powertrain layout,a series of improvements are explored towards how to maximize the use of the engine cooling system withitbeing rear-mounted,to change the design ideas of the vehicle’s aerodynamics accordingly,and to optimize the aerodynamics of each part of the vehicle.The results show that in the case of the rear-mounted engine cooling system,the design ideas of aerodynamic devicesarequite different from the ideas before the change.The aerodynamic devices designed under the new idea have significantly improved the overall performance of the vehicle,which results in a 4% improvement on standard lap time.

关键词： FSAE aerodynamics cooling system rear radiator

Experimental Research of Thermostat Diagnosis for Light Vehicle cooling system

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Experimental Research of Thermostat Diagnosis for Light Vehi...

2021中国汽车工程学会年会暨展览会

作者： Li Hai Liu Yongjun Li Hualong Dongfeng Motor Co. Ltd.Dongfeng Nissan Passenger Vehicle Company Technical Center

China’ s 6 th emission standard（N6） has required OBD system should monitor whether the thermostat is working properly,compared to Emission regulation N5.In this paper,a strategy of thermostat diagnosis was introduced and experimental research of thermostat diagnosis development was executed from three aspects of performance test,vehicle verification,and further development.The main contents are the development and performance calibration of thermostat diagnosis based on N6,including factors,extreme environmental road tests（high temperature,high altitude,and high cold）,and diagnosis characteristic of thermostat under CLTC condition,which would be adopted in N7 in the future.The diagnosis performance developer could fully understand and coordinates the related factors of thermostat in advance.It helps to reduce repeated calibration during the development process and to improve the quality and efficiency of the development.

关键词： thermostat malfunction diagnosis extreme environment road test CLTC cooling system OBD

Simulation and Optimization for an SUV cooling system

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Simulation and Optimization for an SUV Cooling System

2021中国汽车工程学会年会暨展览会

作者： Xu Xiang Zhang Yilun Zhao Feng Yi Hucheng Wang Yuan Xu Junfang CATARC (TianJin) Automotive Engineering Research Institute Co. Ltd

In order to solve the problem that engine coolant outlet temperature of an SUV was too high in low and medium speed climbing and high speed conditions,1 D/3 D co-simulation tool were used to establish a simulation model of whole vehicle cooling system.Through test and simulation,different factors that affect cooling system thermal balance performance were analyzed.The research found out that:Independent cooling loop for transmission and engine can significantly reduce engine coolant outlet temperature.cooling system pipe arrangement has an influence on coolant flow distribution,but has little influence on coolant temperature.By optimizing radiator type and underhood arrangement,underhood flow field characteristics can be improved and inlet air flow rate of cooling system was increased.So the cooling system capacity has been improved.

关键词： cooling system thermal balance co-simulation flow distribution flow field optimization

New Type Regulating Valve Applied in cooling system of Blast Furnace

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Journal of Iron and Steel Research(International) 2004年第2期11卷 1-3页

作者： HE Sheng-ping ZOU De-yu XU Gang LU De-chang Chongqing University Chongqing Iron and Steel Co

A new type regulating valve with the cooling mode of constant temperature difference water supply, temperature difference self operated regulating valve, was introduced into blast furnace cooling system to overcome shortcomings of the cooling mode of constant flow rate water supply. The results show that the temperature difference between inlet and outlet water of cooling wall can be decreased greatly and steadily, and the water supply for blast furnace cooling can be reduced considerably.

关键词： blast furnace cooling system self operated regulating valve

Performance Simulation Study of Vehicle Engine cooling system

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Performance Simulation Study of Vehicle Engine Cooling Syste...

2018中国汽车工程学会年会

作者： LI Xin ZHU Liang ZHU Yongcheng ZENG Zhixin LIU Jujiang Guangzhou Automobile Group Co. Ltd.Automotive Engineering Institute

The cooling system is an important subsystem of the engine,and its performance directly plays a key role in engine performance.In this paper,the vehicle cooling system model is built up with AMESim,which taken the CFD simulation results of the wind speed field and temperature field as input,to simulate the cooling system under the limit steady-state conditions such as low-speed and high-load,high-speed climbing,and NEDC transient conditions.We can calculate the water temperature rise curve of the transient condition,and balanced water temperature of steady state conditions,and then compared with the test The result verifies the correctness of the cooling system model.Finally,the U-type radiator and the improved I-type radiator of a vehicle model are compared analysis to verify the correctness of the cooling system model,and then to obtain the direction of optimization design.The sturdy can make an important application value and theoretical significance to improve the engine cooling system performance.

关键词： cooling system heat transfer coefficient steady state condition NEDC condition optimization design

Study on Effects of Diesel Engine cooling system Parameters on Water Temperature

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Defence Technology（防务技术） 2011年第3期7卷 129-134页

作者：骆清国冯建涛刘国夫桂勇 Department of Mechanical Engineering Academy of Armored Force Engineering Department of Vehicular Engineering Armored Force Technology Institute

A simulation model for a certain diesel engine cooling system is set up by using GT-COOL. The backwater temperature response in different operating conditions is simulated numerically. The effects of single or multiple system parameters on the water temperature are analyzed. The results show that, changing different single parameters, the time taken for the steady backwater temperature is different, but relatively short;and if multiple parameters are changed, the time will be longer. Referred to the thermal balance test, the simulation results are validated and provide a basis for the intelligent control of the cooling system.

关键词： power machinery engineering diesel engine cooling system transient response simulation