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织网奇兵——Macromedia新锐亮点contribute

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电脑爱好者 2003年第5期 78-79页

作者： Coco 风铃工作室

DreamweaverMX虽然早已稳坐网页编辑软件的头把变椅,可是Macromedia公司并未停止其在网络软件领域的拓张步伐。2002年12月,又一款Macromedia家族的新锐产品被推向市场——Cont ribute,它是Macromedia的年终之作,也是继MX系列之后的第四... 详细信息

DreamweaverMX虽然早已稳坐网页编辑软件的头把变椅,可是Macromedia公司并未停止其在网络软件领域的拓张步伐。2002年12月,又一款Macromedia家族的新锐产品被推向市场——Cont ribute,它是Macromedia的年终之作,也是继MX系列之后的第四员悍将。

关键词：编辑数据项 Macromedia contribute

Macaques contribute to New Breakthroughs in Autism Research

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China Today 2019年第8期68卷 7-7页

A China-U.S. joint research team has made new breakthroughs in developing nonhuman primate models for autism research. This does much to pave the way for possible drug discovery and gene therapy of the disorder. The research was conducted by scientists from the Shenzhen Institutes of Advanced Technology (SIAT) under the Chinese Academy of Sciences, Massachusetts Institute of Technology (MIT), Sun Yat-Sen University, and South China Agricultural University.

关键词： Macaques contribute New Breakthroughs Autism Research

Macromedia contribute v1．0

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软件 2003年第1期24卷 21-21页

Macromedia Breeze Live和contribute2新品发布

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大众软件 2003年第17期 21-21页

Propofol reduces synaptic strength by inhibiting sodium and calcium channels at nerve terminals

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Protein & Cell 2019年第9期10卷 688-693页

作者： Qing-Zhuo Liu Mei Hao Zi-Yang Zhou Jian-Long Ge Yi-Chen Wu Ling-Ling Zhao Xiang Wu Yi Feng Hong Gao Shun Li Lei Xue State Key Laboratory of Medical Neurobiology Department of Physiology and BiophysicsSchool of Life Sciences and Collaborative Innovation Centre for Brain ScienceFudan University Shanghai 200438China The Affiliated Hospital of Medical College Ningbo University Ningbo 315020China Department of Critical Care Medicine Shanghai General Hospital Shanghai Jiaotong UniversityShanghai 200080China Department of Orthopaedic Surgery Shanghai Jiaotong University Affiliated Sixth People's HospitalShanghai 200233China Zhejiang Provincial People's Hospital Hangzhou 310000China

Propofol (2,6-diisopropylphenol) has been widely used in clinical surgery because of its fast induction and rapid recovery effects (Miller et al., 2014). Although the underlying mechanisms are still controversial, many studies have focused on the augmentation of GABA-induced inhibition and/or modulation of glycine receptor channel activity. However, inhibition of glutamatergic synaptic transmission may also contribute to general anesthesia. The effects of general anesthetics are significantly enhanced when glutamate receptor antagonists are co-administered (Ishizaki et al., 1996).

关键词： contribute to general anesthesia has been

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A specific assay for JmjC domain-containing lysine demethylase and its application to inhibitor screening

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Science China(Life Sciences) 2019年第10期62卷 1404-1408页

作者： He Wen Guo Li Yongcan Chen Meiting Li Yafei Lv Zhiming Li Yinglu Li Tianyun Hou Hui Wang Chaohua Liu Xiaopeng Lu Qian Zhu Yantao Bao Ge Liu Xiaofan Li Wei-Guo Zhu Guangdong Key Laboratory for Genome Stability and Human Disease Prevention Carson Cancer Research CenterDepartment of Biochemistry and Molecular BiologyShenzhen University Health Science CenterShenzhen 518060China College of Life Sciences and Oceanography Shenzhen Key Laboratory of Marine Bioresource and Eco-environmental ScienceShenzhen Key Laboratory of Microbial Genetic EngineeringShenzhen UniversityShenzhen 518060China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Beijing Key Laboratory of Protein Posttranslational Modifications and Cell FunctionDepartment of Biochemistry and Molecular BiologySchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China

Dear Editor, Chromatin is the macromolecular complex of DNA and histone proteins, which provides the scaffold for the packaging of our entire genome. In the basic unit of chromatin, the nucleosomes contain 147 base pairs of DNA, which is wrapped around a histone octamer, with two each of histones H2A, H2B, H3, and H4. Several types of post-translational modifications, including acetylation, phosphorylation, ubiquitination, and methylation, are possible on the tails of histones (Zhang et al., 2015). Combinations of these modifications determine the chromatin structure and transcriptional regulation of genes. Histone methylation is highlighted because of the specific dynamics related to gene regulation. Aberrant histone methylation has been observed in many types of tumors (Albert and Helin, 2010) and may contribute to the neoplastic transformation of cells (Chi et al., 2010). Histone lysine methylation is regulated by two classes of enzymes that have opposing activities: histone lysine methyltransferases (KMTs) and histone lysine demethylases (KDMs). To date, a number of mammalian KDMs have been discovered (Kooistra and Helin, 2012), and they have been separated into two classes: flavin adenine dinucleotide dependent oxidases, which were first discovered in 2004 (Shi et al., 2004), and Jumonji-C (JmjC) domain-containing enzymes, first identified in 2006 (Tsukada et al., 2006).

关键词： pairs of contribute to neoplastic transformation

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论读者接受的趋真心理对文学真实的建构作用

文艺理论 2001年第7期 40-43页

作者：李莉

读者在文学活动中阅读文本，文本语言的逼真效果使读者在心理上将语言事实趋向于现实事实，为语言魅力所诱导产生思想观念的认同、情感的共鸣及价值意义的生长，从而实现心灵真实。读者接受文本萌发的趋真心理对文学真实的实现起着重要... 详细信息

读者在文学活动中阅读文本，文本语言的逼真效果使读者在心理上将语言事实趋向于现实事实，为语言魅力所诱导产生思想观念的认同、情感的共鸣及价值意义的生长，从而实现心灵真实。读者接受文本萌发的趋真心理对文学真实的实现起着重要的建构作用。

关键词：读者文学真实建构 reader literature truthfulness contribute

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Earth Mothers

ChinAfrica 2019年第1期11卷 34-35页

作者： Francois Essomba 不详

All around Zamakoue,a small town about 35km from Cameroon's capital Yaounde,there are vast manioc fields that extend as far as the eye can *** entire area is under the responsibility of a single woman,Ernestine *** fertile manioc fields provide her with a substantial income and contribute effectively to her personal growth,as well as that of her family as a ***, or cassava,is a tropical vegetable widely grown and consumed in Africa.

关键词： around Zamakoue fertile manioc contribute effectively

S1B-2 Therapeutics and Biomarker Development in Huntington’Disease

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神经药理学报 2018年第4期8卷 28-29页

作者： DUAN Wen-zhen Laboratory of Translational Neurobiology Division of NeurobiologyDepartment of Psychiatry and Behavioral SciencesDepartment of NeuroscienceJohns Hopkins University School of Medicine.BaltimoreMarylandUSA

Most neurodegenerative diseases,including Alzheimer’s,Parkinson’s,and Huntington’s disease(HD),have converging pathogenesis,such as formation of abnormal protein aggregates and mitochondrial ***,despite tremendous efforts by many scientists and increasing knowledge about disease mechanisms,we still lack disease-modifying treatments for any of these *** discovery has been revolutionized in the past *** technological advances as a result of substantial investment,the number of new drug approvals remains stagnant and the cost of bringing a drug to market is higher than *** highlights the persistence of a model of drug development that has not adapted to changes in science and public perception of drug *** these diseases affect different areas of the brain and are distinct at the cellular and molecular levels,they share many underlying ***,development of treatment for any of these diseases may provide clues to accelerate the path to the treatment for other neurodegenerative *** into potential therapies for HD is particularly attractive because it is a genetically homogeneous disease for which well-established models *** HD gene encodes the protein huntingtin(Htt),whose polyglutamine expansion is believed to mediate the cytotoxic effects of ***,HD also serves a model for polyglutamine *** is a monogenic neurodegenerative disorder caused by mutation of the gene *** lowering(gene silencing)strategies,including antisense oligonucleotides,shRNA,miRNA et al,have shown great preclinical promise,and the first HTT lowering clinical trial is *** key to success of these trials will be to know where and when to intervene,since these reagents do not penetrate the blood-brain-barrier,and must be delivered directly to the *** is notable for preferential atrophy of the striatum but also involves degeneration in cortex,subcortical white matter,and specif

关键词： experimental promise treatment cellular contribute effects circuit mutation