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Unveiling the next generation of mri contrast agents:current insights and perspectives on ferumoxytol-enhanced mri

National Science Review 2024年第5期11卷 385-404页

作者： Guangxiang Si Yue Du Peng Tang Gao Ma Zhaochen Jia Xiaoyue Zhou Dan Mu Yan Shen Yi Lu Yu Mao Chuan Chen Yan Li Ning Gu Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical EngineeringSoutheast University Key Laboratory for Bio-Electromagnetic Environment and Advanced Medical Theranostics School of Biomedical Engineering and InformaticsNanjing Medical University Department of Radiology the First Affiliated Hospital of Nanjing Medical University MR Collaboration Siemens Healthineers Ltd. Department of Radiology Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School School of Mathematical Sciences Capital Normal University Nanjing Key Laboratory for Cardiovascular Information and Health Engineering Medicine Institute of Clinical Medicine Nanjing Drum Tower HospitalMedical SchoolNanjing University

contrast-enhanced magnetic resonance imaging(CE-mri) is a pivotal tool for global disease diagnosis and management. Since its clinical availability in 2009, the off-label use of ferumoxytol for ferumoxytol-enhanced mri(FE-mri) has significantly reshaped CE-mri practices. Unlike mri that is enhanced by gadolinium-based contrast agents, FE-mri offers advantages such as reduced contrast agent dosage, extended imaging windows, no nephrotoxicity, higher mri time efficiency and the capability for molecular imaging. As a leading superparamagnetic iron oxide contrast agent, ferumoxytol is heralded as the next generation of contrast agents. This review delineates the pivotal clinical applications and inherent technical superiority of FE-mri, providing an avant-garde medical-engineering interdisciplinary lens, thus bridging the gap between clinical demands and engineering innovations. Concurrently, we spotlight the emerging imaging themes and new technical breakthroughs. Lastly, we share our own insights on the potential trajectory of FE-mri, shedding light on its future within the medical imaging realm.

关键词： ferumoxytol contrast agent contrast-enhanced mri ferumoxytol-enhanced mri

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