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Real-time myocardial contrast echocardiography and its applications in evaluation for coronary artery disease

Chinese Medical Journal 2004年第9期117卷 1388-1394页

作者：杨莉 Department of Cardiology Second Affiliated Hospital Sun Yatsen University Guangzhou 510120 China

Recent improvements in the design of microbubbles and the technology for their detection have enabled myocardial opacification to be achieved by low-energy real-time intravenous MCE. Microbubble replenishment rate and peak intensity after bubble destruction by high-energy ultrasound, as assessed by real-time imaging, provide reliable parameters of regional microcirculatory flow. Real-time imaging offers a rapid and easy means of assessing regional myocardial perfusion with MCE. With the introduction of real-time imaging, wall motion and myocardial perfusion can be assessed together, without the need of time-consuming combination of imaging modes. Recent studies using real-time MCE have underscored its potential in the identification of coronary artery disease, quantification of coronary stenosis severity, assessment of myocardial viability, determination of risk and infarct size, and evaluation of reflow and no-reflow or low-reflow after AMI. However, some limitations, such as basal attenuation and motion artefacts, still exist in the current state of the technique. Further studies, using real-time MCE in normal humans and patients with various stages of coronary artery disease, for quantification of myocardial perfusion and flow reserve in comparison to a reference standard such as quantitative positron emission tomography, will be needed to establish the validity of real-time MCE. If the encouraging preliminary clinical results are confirmed in daily routine patients, real-time MCE may become the method of choice for myocardial perfusion assessment in the near future.

关键词： contrast echocardiography · myocardial perfusion · coronary arteriosclerosis

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