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Biodegradable implants based on photo-cross-linked aliphatic polycarbonates for long-acting contraception

Journal of Materials Science & Technology 2023年第25期156卷 129-141页

作者： Zhipeng Hou Wei Xu Siwen Chen Jing Guo Peng Li Jianshe Hu Liqun Yang Jing Chen Center for Molecular Science and Engineering College of ScienceNortheastern UniversityShenyang 110819China NHC Key Laboratory of Reproductive Health and Medical Genetics (China Medical University) Liaoning Research Institute of Family Planning (The Reproductive Hospital of China Medical University)Shenyang 110031China Department of Biomaterials Shengjing Hospital of China Medical UniversityShenyang 110004China Department of Obstetrics and Gynecology Shengjing Hospital of China Medical UniversityShenyang 110004China

In this study,a new class of biodegradable contraceptive implants was prepared via the UV irradiation molding method,among which,progestin levonorgestrel(LNG)was used as a model ***-cross-linked aliphatic polycarbonates(APCs),namely,poly(trimethylene carbonate-co-2,2′-dimethyltrimethylene carbonate)[P(TMC-co-DTC)]elastomers,were used as the drug delivery *** results obtained from the degradation experiments carried out in Sprague-Dawley(SD)rats showed that the cross-linked elastomer had the degradation characteristics of the surface erosion degradation mechanism,with no generation of acid degradation products,and excellent form-stability,which met the performance requirements of the matrix for a long-acting sustained-release delivery *** in vitro cytotoxicity tests and histological and immunohistochemical evaluations showed good biocompatibility and biosafety of the elastomer matrix material and contraceptive ***,the implant formulations were screened by in vitro release experiments,and their release kinetics were ***,in the evaluation study of the in vivo anti-fertility effect,the implants exhibited excellent dimensional stability and were degraded by a surface erosion *** achieved a stable and sustained release in female SD rats,maintaining a long-acting contraceptive duration of up to 4 *** contraceptive implants obtained in this study could be used to address the limitations of currently available formulations,which required secondary surgical removal and a single means of regulating drug release ***,these implants could provide a new option for birth control needs and may be of significance in reducing the incidence of induced abortion and protecting female fertility.

关键词： Aliphatic polycarbonates Photo-cross-linked Levonorgestrel contraceptive implants Anti-fertility effects Sustained-release

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Ovarian Cysts in Users of Two Kinds of Progestin-only contraceptives implants

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Journal of Reproduction and Contraception 2006年第1期17卷 55-62页

作者： Luis Bahamondes Maria-Margarete Hidalgo Cássia T.Juliato M.Valeria Bahamondes Human Reproduction Unit Department of Obstetrics and GynecologySchool of MedicineUniversidade Estadual de Campinas(UNICAMP)13084-971CampinasSPBrazil

Objective To evaluate the prevalence of functional ovarian cysts in users of two different types of contraceptive implants. Methods A total of 239 women were enrolled at 3 months of use of the etonogestrelreleasing implant （Implanon） and the levonorgestrel-releasing implant （Jadelle）. Bimanual pelvic examination and vaginal ultrasound were performed during routine 3, 6 and 12-month visits of asymptomatic women（control group）. Women with ovarian cysts （or enlarged ovarian follicles 〉25 mm）（cysts group） were assessed weekly until disappearence or reduction of the image （including estradiol （E2） and progesterone measurement and women with no ovarian enlargement underwent same evaluation for the same period of time. Results Ovarian cysts were detected in 5.1% and 13.0% of users of Implanon and Jadelle, respectively, at 3rd month. At the 6th month of use, prevalences were 7.1% and 7.8%, and at 12th month rates were 25.7% and 14.7% in the two groups, respectively. E2 levels were significantly higher in cysts group than in control group. The time until disappearance of the ovarian cyst was similar in Implanon and Jadelle group. There were more cases of menorrhagia in patients rveth ovarian cysts than in patients with no ovarian enlargement. Conclusions The finding of ovarian cysts or enlarged ovarian follicles during the first year of use of Implanon and Jadelle implants is common and transient and should not be interpreted as a pathologic ovarian cyst. No further medical interventions are necessary.

关键词： contraceptive implants Implanon Jadelle ovarian follicles

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