检索结果-南通市图书馆

Corneal sensitivity,ocular surface health and tear film stability after punctal plug therapy of aqueous deficient dry eye

引用

International Journal of Ophthalmology(English edition) 2016年第11期9卷 1598-1607页

作者： Azza Mohamed Ahmed Said Mona Elsayed Farag Tarek Mohamed Abdulla Othman Ali Othman Ziko Wesam Mohamed Osman Ophthalmology Department Faculty of MedicineAin Shams University Pathology Department Faculty of MedicineAin Shams University

AIM： To evaluate the effect of punctal occlusion using thermosensitive（smart plug） versus silicone plug for management of aqueous deficient dry eye on cornea sensitivity, ocular surface health and tear film ***： A comparative prospective interventiona case study included 45 patients with bilateral severe form of aqueous deficient dry eye. In each patient, the smar plug was inserted in the lower punctum of the right eye which was considered as study group 1 and silicone plug was inserted in the lower punctum of the left eye o the same patient which was considered as study group2. All patients were subjected to careful history taking and questionnaire for subjective assessment of severity of symptoms. Corneal sensitivity, corneal fluorescein rose bengal staining, Schirmer＇s I test, tear film break up time and conjunctival impression cytology were performed pre and 1, 3 and 6mo post plug ***： A statistically significant improvement in subjective and objective manifestations occurred following treatment with both types of plugs（P 〈0.01）The thermosensitive plug caused significant overal improvement, decrease in frequency of application o tear substitutes and improvement of conjunctiva impression cytology parameters in the inserted side（P 〈0.01）. Canaliculitis was reported in two eyes（4.4% following punctal occlusion using thermosensitive plug（study group 1）. Spontaneous plug loss occurred in 21eyes（46.6%） in the silicone plug group（study group 2）.CONCLUSION： Improvement of subjective and objective manifestations of aqueous deficient dry eye occurs following punctal plug occlusion. Thermosensitive plug has good patient＇s compliance with fewer complications and lower rates of loss compared to the silicone plug.

关键词： conjunctival impression cytology comealsensitivity corneal fluorescein staining dry eye syndrome Schirmer's test silicone plug thermosensitive smart plug

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A randomized controlled trial of omega-3 fatty acids in dry eye syndrome

引用

International Journal of Ophthalmology(English edition) 2013年第6期6卷 811-816页

作者： Rahul Bhargava Prachi Kumar Manjushrii Kumar Namrata Mehra Anurag Mishra Department of Ophthalmology Santosh Medical College and Hospital Department of Pathology Santosh medical College andHospital Department of Microbiology Narayan Medical College andHospital

AIM:To evaluate the role of dietary supplementation of omega-3 fatty acids in dry eye ***:A prospective,interventional,placebo controlled,double blind randomized trial was done at two referral eye *** hundred and sixty-four eyes of patients with dry eye were randomized to receive one capsule(500mg)two times a day containing 325mg EPA and 175mg DHA for 3 months(omega-3 group).The omega-3 group was compared to a group of patients(n=254)who received a placebo(placebo group).There were 4 patient visits(at baseline,1 month,2 months and3 months).On each visit,recording of corrected distance visual acuity(CDVA),slit lamp examination and questionnaire based symptom evaluation and scoring was done.A symptomatic score of 0-6 was mild,6.1-12moderate and 12.1-18 severe dry *** to intervention was monitored by routine tear function tests like Schirmer I test,tear film break-up time(TBUT),Rose Bengal staining and most notably,conjunctival impression ***:Sixty-five percent of patients in the omega-3group and 33%of patients in placebo group had significant improvement in symptoms at 3 months(P=0.005).There was a significant change in both Schirmer’s test value and TBUT values in the omega-3group(P<0.001),both ***,there was a larger drift in TBUT values in omega-3 than the placebo group,in comparison to Schirmer’s test *** mean TBUT score was 2.54±2.34 in the omega-3group and 0.13±0.16 in placebo group,*** mean reduction in symptom score in omega-3 group was 2.02±0.96 as compared to 0.48±0.22 in placebogroup(P<0.001).Despite a slight increase mean score,the Schirmer scores did not correlate well with symptomatic ***:Omega-3 fatty acids have a definite role for dry eye *** benefit seems to be more marked in conditions such as blepharitis and meibomian gland *** role of omega fatty acids in tear production and secretion needs further evaluation.

关键词： dry eye syndrome omega-3 fatty acids conjunctival impression cytology meibomian gland disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical efficacy of 0.1% pranoprofen in treatment of dry eye patients：a multicenter, randomized, controlled clinical trial

引用

Chinese Medical Journal 2014年第13期127卷 2407-2412页

作者： Chen Jingyao Dong Fei Chen Wei Sun Xuguang Deng Yingping Hong Jing Zhang Mingchang Yang Wenzhao Liu Zuguo Xie Lixin Eye Institute of )~iamen University Medical College of XiamenUniversity Xiamen Fujian 361102 China Affiliated Eye Hospital of Wenzhou Medical Collage WenzhouZhejiang 325072 China Beijing Institute of Ophthalmology Department of OphthalmologyBeijing Tongren Hospital Capital Medical University Beijing100730 China West China School of Medicine Sichuan University ChengduSichuan 610041 China Department of Ophthalmology Peking University Third HospitalBeijing 100191 China Huazhong University of Science and Technology Wuhan Hubei430022 China Shandong Eye Institute Qingdao Shandong 266071 China

Background Dry eye is a multifactorial disease of the tears and the ocular *** study aimed to investigate the clinical efficacy of a non-steroidal anti-inflammatory drug,pranoprofen,in the treatment of dry *** It is a prospective,multi-center,randomized,controlled,parallel group *** hundred and fifteen patients with mild to moderate dry eye disease （55-60 in each treatment group） participated in this multi-center *** were randomly administered with eyedrops containing 0.1％ pranoprofen （PRA） plus 0.1％ sodium hyaluronate （SH） or SH only,three times daily for 28 days,followed by a 1-week after treatment *** eye symptom score （DESS）,fluorescein corneal staining （FLCS）,tear break-up time （TBUT）,and Shirmer 1 tear test （ST1,without anesthesia） were evaluated or conducted before treatment and at each study *** impression cytology was taken from the patients treated with PRA plus SH before and after treatment and real-time polymerase chain reaction （RT-PCR） was performed to detect the changes of human leukocyte antigen DR （HLA-DR） and intercellular adhesion molecule 1 （ICAM-1）.Results Patients treated with PRA plus SH showed gradual improvements of DESS,FLCS,and ***-group comparisons of FLCS and TBUT have statistically significant differences from day *** tolerance with no severe adverse events was found in both *** treated with PRA plus SH had a reduced expression level of HLA-DR and were statistically different after 28 days of *** The application of PRA at a dose of 0.1％ was well tolerated and benefited to the patients with mild to moderate dry eye *** underlying mechanism of its efficacy may be associated with the reduction of inflammatory factors of conjunctival epithelial cells.

关键词： dry eye nonsteroidal anti-inflammatory drug inflammation treatment conjunctival impression cytology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：