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Comparative clinical study of conjunctival toxicities of newer generation fluoroquinolones without the influence of preservatives

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International Journal of Ophthalmology(English edition) 2015年第6期8卷 1220-1223页

作者： Han Sang Park Jun Hun Lee Hong Kyun Kim Nune Eye Hospital Department of Ophthalmology Kyungpook National University School of Medicine

AIMTo compare the conjunctival epithelial toxicities of three newer-generation fluoroquinolones without *** a prospective, randomized, double blind comparative study, 47 eyes of 47 patients with a primary pterygium were enrolled, and divided randomly into three groups (levofloxacin 0.5%, gatifloxacin 0.3%, and moxifloxacin 0.5%). After pterygium surgery with the same conjunctival autograft technique, each patient maintained a regimen with a randomly assigned fluoroquinolone eye drop. Patients were examined every other day after surgery until the epithelium had completely healed. Photos were taken and used to measure the area of residual epithelial defects. conjunctival healing time and speed (initial defect area/healing time (mm2/d) compared in each group using Kruskal-Wallis *** were no significant differences in mean age, gender, and conjunctival defect size of the donor site between these groups. However, the mean of conjunctival healing time and speed were statistically different in each group. The mean of conjunctival epithelial healing time was 8.93±2.69d (levofloxacin group), 10.31±2.96d (gatifloxacin group), and 13.50±4.10d (moxifloxacin group), P=0.006. The mean conjuctival epithelial healing speed was 6.18±1.39 mm2/d (levofloxacin group), 5.52±1.68 mm2/d (gatifloxacin group), and 4.40±1.30 mm2/d (moxifloxacin group), P=0. *** the influence of preservatives, levofloxacin and gatifloxacin might be less toxic to the regeneration of conjunctival epithelial cells and cause a faster conjunctival wound healing relative to moxifloxacin.

关键词： conjunctival epithelial toxicity fluoroquinolone preservatives pterygium

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