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Technical and Dosimetric Study of Four Facio-cervical Fields conformal radiotherapy for Nasopharyngeal Carcinoma

Chinese Journal of Biomedical Engineering(English Edition) 2015年第1期24卷 28-32页

作者： WANG Fang-zheng FU Zhen-fu WANG Lei PIAO Yong-feng HUA Yong-hong CHEN Wei-jun XU Min Department of Radiation Oncology Zhejiang Tumor Hospital

Objective: The aim of this study is to establish the methods of four facio-cervical field's conformal radiotherapy(4F-CRT) for nasopharyngeal carcinoma(NPC), and to optimize the methods for clinical practice. Materials and Methods:40 patients with untreated NPC of T1-T4(1997 AJCC Staging System) were rolled into this *** and four facio-cervical fields conform plans were designed for each patient using Pinnacle 8.0 three-dimension treatment planning system(3D-TPS)as follows: 1. Improved plan, four facio-cervical field's conform plan, anterior, posterior facio-cervical and two lateral opposing facio-cervical fields; 2. Conventional plan, two lateral opposing facio-cervical fields delivered to the target in each plan, only with the same dose dose volume histograms(DVHs) of the targets and normal organs, brain stem,spinal cord, parotid glands, and temporal mandibular joints(TMJs) were compared and the dose distribution were evaluated. Results: *** dose distribution of the improved plan could meet the requirements for the target volume. 2. There was not any significant difference in the dose of spinal cord between the two *** mean doses of Dmaxfor brain stem in conventional plan were much lower than those in the improved plan,though both were within safety limits. 3. Compared with the conventional plans, the improved plan significantly decreased the hotspot areas in the target volume and had better parotid glands and temporal mandibular joints sparing effect. Conclusion:Compared with the conventional plan, the improved plan provides satisfactory dose coverage to the tumor volume and better sparing of the parotid gland, TMJs and other normal tissues in external beam radiotherapy of NPC.

关键词： asopharyngeal neoplasms four facio-cervical fields conformal radiotherapy TPS dosimetry

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Technical and Dosimetric Study of Four Facio-cervical Fields conformal radiotherapy for Nasopharyngeal Carcinoma

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Chinese Journal of Biomedical Engineering(English Edition) 2012年第3期21卷 129-133页

作者： WANG Fang-zheng FU Zhen-fu WANG Le PIAO Yong-feng HUA Yong-hong CHEN Wei-jun XU Min Department of Radiation Oncology Zhejiang Tumor Hospital

Objective： The aim of this study is to establish the methods of four facio-cervical fields＇ conformal radiotherapy （4F-CRT） for nasopharyngeal carcinoma （NPC）, and to optimize the methods for clinical practice. Methods and Materials： 40 patients with untreated NPC of T1-T4 （1997AJCC Staging System） were rolled into this study. Conventional and four ratio-cervical fields conform plans were designed for each patient using Pinnacle 8.0 three-dimension treatment planning system （3D-TPS）： 1） Improved plan, four ratio-cervical fields＇conform plans, anterior, posterior ratio-cervical and 2 lateral opposing facio-eervical fields; 2） Conventional plan, two lateral opposing facio-cervical fields only with the same dose delivered to the target in each plan, close volume histograms （DVHs） of the targets and normal organs, brain stem, spinal cord, parotid glands, and temporal mandibular joints （TMJs） were compared and the dose distribution were evaluated. Results： 1） The dose distribution of the improved plan could meet the requirements for the target volume. 2） There was not any significant difference in the dose of spinal cord between the two plans. The mean doses of Dmax for brain stem in conventional plan were much lower than those in the improved plan, though both were within safety limits. 3） Compared with the conventional plans, the improved plan significantly decreased the hotspot areas in the target volume and had better parotid glands and temporal mandibular joints sparing effect. Conclusion： Compared with the conventional plan, the improved plan provides satisfactory dose coverage to the tumor volume and better sparing of the parotid gland, TMJs and other normal tissues in external beam radiotherapy of NPC.

关键词： nasopharyngeal neoplasms four facio-cervical fields conformal radiotherapy TPS dosimetry

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The clinical observation of three-dimensional conformal radiotherapy combined with FOLFOX chemotherapy for rectal cancer of postoperative local recurrence

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The Chinese-German Journal of Clinical Oncology 2012年第8期11卷 465-468页

作者： Yeqin Zhou Mi Liu Daiyuan Ma Tao Ren Xiaojie Ma Xian fu Li Bangxian Tan Department of radiotherapy Affiliated Hospital of North Sichuan Medical College Nanchong 637000 China

Objective The aim of this study was to explore the three-dimensional conformal radiotherapy combined with FOLFOX scheme chemotherapy in the treatment of postoperative recurrence of rectal cancer.

关键词： rectal neoplasm tumor recurrence conformal radiotherapy chemotherapy

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Dosimetric study comparing intensity modulated and conformal pelvic radiotherapy boost plans in locally advanced cancer cervix in NCI-Cairo

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The Chinese-German Journal of Clinical Oncology 2013年第6期12卷 293-296页

作者： Mohamed Mahmoud Hesham A. EL-Hossiny Nashaat A. Diab Mahmoud Shosha Department of Radiation Oncology National Cancer InstituteCairo University Department of Radiation Physics National Cancer InstituteCairo University

Objective:This study was to compare 5 field conformal technique to the intensity modulated radiotherapy (IMRT) 8 fields technique in boosting locally advanced cancer cervix cases after external beam radiotherapy with respect to target volume coverage and dose to normal tissues. Methods:We conducted a single institutional comparative dosimetric analysis of 10 patients with cancer cervix who was presented to radiotherapy department in National Cancer Institute, Cairo in period between June 2012 to September 2012 and received a CRT boost in the place of planned brachytherapy after large field pelvic radiotherapy (PRT) with concurrent chemotherapy were retrospectively identified. All tumors were situated in the low central pelvis. Two plans were done for every patient; one using the 8 fields IMRT and the second one using 5 fields' 3DCRT the two techniques were then compared using dose volume histogram (DVH) analysis for the PTV, bladder, rectum and both femoral heads. Results:Comparing different DVHs, it was found that the planning target volume (PTV) was adequately covered in both plans while it was demonstrates that the 8 fields IMRT technique carried less doses reaching OARs (rectum, bladder, both femoral heads). Conclusion:From the present study, it is concluded that IMRT technique spared more efficiently OARs than CRT technique but both techniques covered the PTV adequately so whenever possible IMRT technique should be used.

关键词： cancer cervix intensity modulated radiotherapy conformal radiotherapy

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Treatment results and prognostic analysis of 1093 primary nasopharyngeal carcinoma: the experience of a single institution of Guangzhou in the beginning of the 21st century

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The Chinese-German Journal of Clinical Oncology 2008年第4期7卷 187-195页

作者： Xiaoqing Liu Wei Luo Mengzhong Liu Ling Ye Ying Sun Yunfei Xia Department of Radiation Oncology Cancer Center Sun Yat-sen University Guangzhou 510060 China

Objective： To analyze the treatment results of primary nasopharyngeal carcinoma （NPC） treated in our institution in the beginning of the 21st century to identify key failures and late effects for refining future treatments. Methods： 1093 patients with primary NPC treated during December 2001 and June 2003 were retrospectively analyzed. The distribution according to the AJCC/UICC （2002 edition） staging system was stage Ⅰ in 5.8%, stage Ⅱ 40.2%, stage Ⅲ 32.7% and stage Ⅳa-b 21.3%. Four different ERT techniques were used： fluoroscopy simulation conventional radiotherapy （CR） in 74.3% of patients, computer tomography simulation conventional radiotherapy （CT-sim CR） 14.2%, three-dimensional conformal radiotherapy （3D-CRT） 6.3%, intensity modulated radiotherapy （IMRT） 5.2%. In the whole series, 46.7% of patients had additional treatment with chemotherapy. Results： The 4-year local failure-free rate （LFFR）, nodal failure-free rate, distant metastasis-free rate, progression-free survival and overall survival （OS） was 89.6%, 96.1%, 85.9%, 73.0% and 82.4%, respectively. The stage was the most important prognostic factor. The 4-year OS and LFFR of patients treated by CR, CT-sim CR, 3D-CRT and IMRT was 80.2%, 89.8%, 89.8%, 92.4% and 87.7%, 96.4%, 91.0%, 96.5%, respectively. The morbidity and degree of xerostomia and trismus were lower in the patients treated by 3D-CRT and IMRT than by CR and CT-sim CR. Conclusion： Treatment results of primary NPC in our institution have been substantially improved. Distant metastasis is the main failure. The CT simulation and conformal radiotherapy can enhance the OS and LFFR, and conformal radiotherapy can reduce the morbidity and degree of late effects.

关键词： nasopharyngeal carcinoma external beam radiation therapy conformal radiotherapy survival pattern of failure

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