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concentrated growth factor regulates the macrophage-mediated immune response

Regenerative Biomaterials 2021年第6期8卷 59-68页

作者： Haiyun Luo Wenjing Liu Yachuan Zhou Xiao Jiang Yeungyeung Liu Qin Yang Longquan Shao Department of Endodontics Stomatological HospitalSouthern Medical University366 Jiangnan Avenue SouthGuangzhou 510280China Department of Prosthodontics Stomatological HospitalSouthern Medical UniversityGuangzhou 510280China State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityNO.143rd Section of Ren Min Nan Rd.Chengdu 610041China Department of Oral Medicine Stomatological HospitalSouthern Medical UniversityGuangzhou 510280China Department of Periodontics Stomatological HospitalSouthern Medical UniversityGuangzhou 510280China

concentrated growth factor(CGF)is a promising regenerative material that serves as a scaffold and adjunct growth factor for tissue engineering.The host immune response,particularly macrophage activity,plays a critical role in injury repair and tissue regeneration.However,the biological effect of CGF on the immune response is not clear.To enrich the theoretical groundwork for clinical application,the present study examined the immunoregulatory role of CGF in macrophage functional activities in vitro.The CGF scaffold appeared as a dense fibrin network with multiple embedded leukocytes and platelets,and it was biocompatible with macrophages.concentrated bioactive factors in the CGF extract enhanced THP-1 monocyte recruitment and promoted the maturation of suspended monocytes into adherent macrophages.CGF extract also promoted THP-1 macrophage polarization toward the M2 phenotype with upregulated CD163 expression,as detected by cell morphology and surface marker expression.A cytokine antibody array showed that CGF extract exerted a regulatory effect on macrophage functional activities by reducing secretion of the inflammatory factor interleukin-1b while inducing expression of the chemokine regulated on activation,normal T cell expressed and secreted.Mechanistically,the AKT signaling pathway was activated,and an AKT inhibitor partially suppressed the immunomodulatory effect of CGF.Our findings reveal that CGF induces a favorable immune response mediated by macrophages,which represents a promising strategy for functional tissue regeneration.

关键词： concentrated growth factor immune response macrophage signaling pathway

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Observation on the Clinical Effect of Breast Augmentation by Transplanting concentrated growth factor and Autologous Fat

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Chinese Journal Of Plastic and Reconstructive Surgery 2019年第3期1卷 18-23页

作者： Ling-ling ZHAO Qing-chun XI Ming-song FANG Xuan LI Ling CAO Pong-fei SANG Chang LIU Department of Burns and Plastic Surgery The Second people’s Hospital of HefeiAnhui Province230000China

Objective To explore the effect of concentrated growth factor(CGF)combined with autologous fat transplantation in augmentation mammoplasty.Methods Clinical data of 28 female patients who underwent autologous fat by CGF mixed with purified fat between May 2015 and June 2018 were retrospectively analyzed.Clinical evaluation was performed to observe and measure the shape of the breast after breast augmentation,the increase in the value of the nipple plane measurement,and complications.Results All of 28 patients,after 12 months of follow-up,all patients no fat infection,hematoma,breast nodules and other complications.It showed that the contouring of breast were improved and more chubbiness than that before operation.The results were satisfied from patients.Conclusion concentrated growth factor combined with autologous fat transplantation has a stable breast augmentation effect,beautiful breast shape,simple operation and small damage,which achieves breast rejuvenation.

关键词： concentrated growth factor Breast augmentation Autologous fat transplantation Breast rejuvenation

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