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computed tomography and photoacoustic imaging guided photodynamic therapy against breast cancer based on mesoporous platinum with insitu oxygen generation ability

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Acta Pharmaceutica Sinica B 2020年第9期10卷 1719-1729页

作者： Lingyan Zhang Mifang Li Quan Zhou Meng Dang Yuxia Tang Shouju Wang Jijun Fu Zhaogang Teng Guangming Lu Department of Medical imaging Jinling HospitalThe First School of Clinical MedicineSouthern Medical UniversityNanjing 210002China Department of Medical imaging The Third Affiliated HospitalSouthern Medical UniversityGuangzhou 510630China Key Laboratory for Organic Electronics&Information Displays and Institute of Advanced Materials Jiangsu Key Laboratory for BiosensorsJiangsu National Synergetic Innovation Centre for Advanced MaterialsNanjing University of Posts and TelecommunicationsNanjing 210046China Departm ent of Medical imaging Jiangsu Province HospitalNanjing 210029China Key Laboratory of Molecular Target&Clinical Pharmacology School of Pharmaceutical SciencesGuangzhou Medical UniversityGuangzhou 511436China

Photodynamic therapy(PDT)has been widely used in cancer ***,hypoxia in most solid tumors seriously restricts the efficacy of *** improve the hypoxic microenvironment,we designed a novel mesoporous platinum(mPt)nanoplatform to catalyze hydrogen peroxide(H2 O2)within the tumor cells in situ without an extra *** the fabrication,the carboxy terminus of the photosensitizer chlorin e6(Ce6)was connected to the amino terminus of the bifunctional mercaptoaminopolyglycol(SH-PEG-NH2)by a condensation reaction,and then PEG-Ce6 was modified onto the mPt moiety via the mercapto terminal of ***,cellular and animal experiments demonstrated that Pt@PEG-Ce6 catalyzed H2 O2 to produce oxygen(O2)and that Ce6 transformed O2 to generate reactive oxygen species(ROS)upon laser *** Pt@PEG-Ce6 nanoplatform with uniform diameter presented good biocompatibility and efficient tumor *** to the high atomic number and good near-infrared absorption for Pt,this Pt@PEG-Ce6 nanoplatform showed computed tomography(CT)and photoacoustic(PA)dual-mode imaging ability,thus providing an important tool for monitoring the tumor hypoxic ***,the Pt@PEG-Ce6 nanoplatform reduced the expression of hypoxia-inducible factor-la(HIF-1α)and programmed death-1(PD-1)in tumors,discussing the relationship between hypoxia,PD-1,and PDT for the first time.

关键词： Mesoporous platinum Photodynamic therapy Tumor hypoxia Photoacoustic imaging computed tomography imaging

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Facile assembling of novel polypyrrole nanocomposites theranostic agent for magnetic resonance and computed tomography imaging guided efficient photothermal ablation of tumors

Facile assembling of novel polypyrrole nanocomposites theran...

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中国化学会第十届全国无机化学学术会议

作者： Minyi Zhang Nannan Zheng Wenyan Kong Dawei Yan Jie Lu Xijian Liu College of Chemistry and Chemical Engineering Shanghai University of Engineering Science

Multifunctional nanocomposites for image-guided cancer therapy are highly desired in clinical application. Herein, a novel theranostic agent based on gold and ferroferric oxide nanoparticles coating polypyrrole particles(PPy@FeO/Au nanocomposites) for computed tomography(CT) and magnetic resonance(MR) imaging guided photothermal therapy was successfully assembled by a very facile electrostatic adsorption method. PPy@FeO/Au nanocomposites exhibit good biocompatibility in vitro and in vivo. Because of high r2 relaxivity of FeO and high X-ray attenuation ability of Au, the PPy@FeO/Au nanocomposites exhibited desirable CT and MR imaging performance, which provide more comprehensive and accurate diagnostic information. Moreover, PPy@FeO/Au nanocomposites can efficiently kill cancer cells by hyperthermia with the guiding of CT and MR imaging, even completely ablate tumors. Hence, the electrostatic adsorption assembled PPy@FeO/Au nanocomposites have great potential in clinical application for diagnosing and treating tumor in the future.

关键词： photothermal therapy computed tomography imaging theranostic agent polypyrrole nanocomposites

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Radiation Dose from CT-Scan of Childhood’s Head: Results of the First Ivorian Survey in a Single Study Site

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Journal of Applied Mathematics and Physics 2024年第5期12卷 1725-1732页

作者： Koutoua Joseph Anouan Adjoua Sonia Dje Idrissa Garba Yoh Esther Soro Nuclear Physics and Radiation Protection Team Training and Research Unit&#8212Sciences of the Structures of Matter and Technology University F&#233lix Houphouet-Boigny of Abidjan Abidjan C&#244te d&#8217Ivoire Department of Medical Pediatrics and Specialties University Hospital of Angr&#233 Abidjan C&#244te d&#8217Ivoire Department of Radiodiagnosis and Medical imaging University Hospital of Angr&#233 Abidjan C&#244te d&#8217Ivoire

Objectives: This study aims to evaluate the level of X-ray doses used in childhood’s head as Local Diagnostic Reference Levels (LDRLs) in computed tomography (CT) at a university hospital in Côte d’Ivoire. The Diagnostic Reference Level (DRL) have been set up and used to prevent unusually high radiation doses used in radiology departments and is therefore an optimization tool for practices and procedures in medical X-ray imaging for the radiation protection of patients. Methods: A prospective study of volume CT dose index (CTDIvol) and dose length product (DLP) was performed on images of childhood’s head obtained from a CT-scanner of 64 bars equipped with the tube current modulation capability and manufactured by Hitachi Medical System. 122 CT-scan data from 55 childhood’s head were analyzed. The scan data were stratified in four age groups: Results: The 75th percentile of CTDIvol and DLP (set as LDRL) obtained with respect to the stratified age groups are: 22.5 mGy and 452.5 mGy∙cm, 27.7 mGy and 690.6 mGy∙cm, 28 mGy and 722.4 mGy∙cm, 33.6 mGy and 736.8 mGy∙cm respectively. These outcome values increase with respect to the age of pediatric patients and are comparable to DRLs values obtained internationally. Conclusions: Obtaining good image quality while using low dose in children’s head computed tomography for radiation protection require to setup more surveys in Côte d’Ivoire for regional and national DRL. We proposed through this survey LDRLs in terms of CTDIvol and DLP, comparable to international DRLs values. This survey will be strengthened by additional surveys in order to obtain national DRLs for the radiation protection of the child patient in Côte d’Ivoire.

关键词： Radiation Protection computed tomography imaging Childhood Diagnostic Reference Levels

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Epidemiological features and dynamic changes in blood biochemical indices for COVID-19 patients in Hebi

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World Journal of Clinical Cases 2022年第8期10卷 2404-2419页

作者： Xiao-Bo Nie Bao-Sheng Shi Lin Zhang Wei-Li Niu Ting Xue Lan-Qing Li Xiao-Yun Wei Yan-Dong Wang Wei-Dong Chen Rui-Fang Hou Key Laboratory of Receptors-Mediated Gene Regulation School of Basic Medical SciencesHenan UniversityKaifeng 475004Henan ProvinceChina Department of Infectious Diseases The People’s Hospital of HebiHebi 458031Henan ProvinceChina Department of Infectious Diseases The Third People’s Hospital of HebiHebi 458031Henan ProvinceChina College of Life Science and Technology Beijing University of Chemical TechnologyBeijing 100029Beijing ProvinceChina Department of Infectious Diseases The People’s Hospital of HebiHenan UniversityHebi Key Laboratory of Liver DiseaseHebi 458031Henan ProvinceChina

BACKGROUND Millions of people have died of coronavirus disease 2019(COVID-19)due to severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)infection,and retrospective studies of the disease in local regions are *** To characterize the epidemiological features and dynamic changes in blood biochemical indices for SARS-Co V-2-infected patients in Hebi,a representative city with a large floating population in North *** From January 25 to February 10,2020,the clinical data of patients who tested positive for SARS-Co V-2 by quantitative real-time polymerase chain reaction in Hebi city(China)were evaluated at admission,and laboratory data for hematologic parameters,inflammatory indices,coagulation function indices,liver function indices,blood lipid indices,renal function indices,myocardial enzyme activities and five blood biochemical markers of immunity were evaluated at admission,upon hospitalization and before *** Sixteen confirmed COVID-19 patients developed pneumonia but were cured after adequate *** and fatigue were the common *** most common laboratory abnormalities of patients at admission were leukopenia,eosinopenia,decreased percentage of eosinophils,elevated high sensitivity C-reactive protein and fibrinogen levels,hypoalbuminemia,mildly increased aspartate transferase activity and levels of bilirubin,and increased levels ofβ***,aggravated liver dysfunction was detected in most patients,which may be partially attributed to virus infection as well as medicinal *** This study provides several potential diagnostic markers and dynamic biochemical indices of disease progression to better prevent,diagnose and treat COVID-19 infection.

关键词： COVID-19 Epidemiology Blood biochemical indices computed tomography imaging Liver dysfunction

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Recent therapeutic applications of the theranostic principle with dendrimers in oncology

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Science China Materials 2018年第11期61卷 1367-1386页

作者： Serge Mignani Joao Rodrigues Helena Tomas Anne-Marie Caminade Regis Laurent Xiangyang Shi Jean-Pierre Majoral Universite Paris Descartes PRES Sorbonne Paris CiteCNRS UMR 860Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique45rue des Saints Peres75006 ParisFrance CQM-Centro de Quimica da Madeira MMRGUniversidade da MadeiraCampus da Penteada9020-105FunchalPortugal School of Materials Science and Engineering/Center for Nano Energy Materials Northwestern Polytechnical UniversityXi＇an 710072China Laboratoire de Chimie de Coordination du CNRS 205 Route de NarbonneBP 4409931077 Toulouse Cedex 4France Universite de Toulouse UPSINPT31077 Toulouse CedexFrance State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China

At the intersection between treatment and diagnosis, nanoparticles technologies are strongly impacting the development of both therapeutic and diagnostic ***, the development of novel modalities for concomitant noninvasive therapy and diagnostics known as theranostics as a single platform has gained significant interests. These multifunctional theranostic platforms include carbon-based nanomaterials（e.g., carbon nanotubes）, drug conjugates, aliphatic polymers, micelles, vesicles, core-shell nanoparticles, microbubbles and dendrimers bearing different contrast agents and drugs, such as cytotoxic compounds in the oncology domain. Dendrimers emerged as a new class of highly tunable hyperbranched polymers, and have been developed as useful theranostic platforms. Magnetic resonance imaging, gamma scintigraphy, computed tomography and optical imaging are the main techniques developed with dendrimers in the theranostic domain in oncology. Different imaging agents have been used such as Gd（Ⅲ）,19F, Fe2O3（MRI）,76Br（PET）,111In,88Y,153Gd,188Re,131I（SPECT）,177Lu,gold（CT） and boronated groups, siliconnaphthalocyanines,dialkylcarbocyanines and QDs（optical imaging dyes）.

关键词： theranostic platforms dendrimers magnetic resonance imaging gamma scintigraphy imaging computed tomography imaging optical imaging

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