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Recent developments of neuroprotective agents for degenerative retinal disorders

Neural Regeneration Research 2022年第9期17卷 1919-1928页

作者： Kepeng Ou Youjian Li Ling Liu Hua Li Katherine Cox Jiahui Wu Jian Liu Andrew D.Dick College of Pharmacy National&Local Joint Engineering Research Center of Targeted and Innovative TherapeuticsIATTIChongqing University of Arts and SciencesChongqingChina Translational Health Sciences Bristol Medical SchoolUniversity of BristolBristolUK Department of Ophthalmology Yongchuan HospitalChongqing Medical UniversityChongqingChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina Institute of Ophthalmology University College LondonLondonUK National Institute for Health Research Biomedical Research Centre Moorfields Eye HospitalLondonUK

Retinal degeneration is a debilitating ocular complication characterized by the progressive loss of photoreceptors and other retinal neurons,which are caused by a group of retinal diseases affecting various age groups,and increasingly prevalent in the ***-related macular degeneration,diabetic retinopathy and glaucoma are among the most common complex degenerative retinal disorders,posing significant public health problems worldwide largely due to the aging society and the lack of effective *** pathoetiologies vary,if left untreated,loss of retinal neurons can result in an acquired degeneration and ultimately severe visual *** of underlined etiology,loss of neurons and supporting cells including retinal pigment epithelium,microvascular endothelium,and glia,converges as the common endpoint of retinal degeneration and therefore discovery or repurposing of therapies to protect retinal neurons directly or indirectly are under intensive *** review overviews recent developments of potential neuroprotectants including neuropeptides,exosomes,mitochondrial-derived peptides,complement inhibitors,senolytics,autophagy enhancers and antioxidants either still experimentally or in clinical *** treatments that possess direct or indirect neuroprotective properties would significantly lift the burden of visual handicap.

关键词： antioxidants autophagy enhancers complement inhibitors exosomes neuropeptides neuroprotective agents retinal degeneration senolytics

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