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Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage

Neural Regeneration Research 2020年第10期15卷 1920-1930页

作者： Ye Xiong Dan-Qing Xin Quan Hu Ling-Xiao Wang Jie Qiu Hong-Tao Yuan Xi-Li Chu De-Xiang Liu Gang Li Zhen Wang Department of Physiology School of Basic Medical SciencesShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Qilu Hospital of Shandong University and Brain Science Research InstituteShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Taian Central HospitalTaianShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesShandong UniversityJinanShandong ProvinceChina

Hydrogen sulfide,which can be generated in the central nervous system from the sulfhydryl-containing amino acid,L-cysteine,by cystathionine-β-synthase,may exert protective effects in experimental subarachnoid hemorrhage;however,the mechanism underlying this effect is *** study explored the mechanism using a subarachnoid hemorrhage rat model induced by an endovascular perforation *** were treated with an intraperitoneal injection of 100 mM L-cysteine(30μL)30 minutes after subarachnoid *** 48 hours after subarachnoid hemorrhage,hematoxylin-eosin staining was used to detect changes in prefrontal cortex cells.L-cysteine significantly reduced cell *** function was assessed using a modified Garcia *** water content was measured by the wet-dry method.L-cysteine significantly reduced neurological deficits and cerebral edema after subarachnoid *** was used to detect the number of activated *** transcription-polymerase chain reaction(RT-PCR)was used to detect the levels of interleukin 1β and CD86 mRNA in the prefrontal cortex.L-cysteine inhibited microglial activation in the prefrontal cortex and reduced the mRNA levels of interleukin 1βand ***-PCR and western blot analysis of the complement system showed that L-cysteine reduced expression of the complement factors,C1q,C3αand its receptor C3aR1,and the deposition of C1q in the prefrontal *** staining was applied to detect changes in reactive oxygen species,and immunohistochemistry was used to detect the number of NRF2-and HO-1-positive cells.L-cysteine reduced the level of reactive oxygen species in the prefrontal cortex and the number of NRF2-and HO-1-positive *** blot assays and immunohistochemistry were used to detect the protein levels of CHOP and GRP78 in the prefrontal cortex and the number of CHOP-and GRP78-positive cells.L-cysteine reduced CHOP and GRP78 levels and the number of CHOP-and GRP78-

关键词： aminooxyacetic acid central nervous system complement deposition cystathionine-β-synthase early brain injury endoplasmic reticulum stress hydrogen sulfide neuroinflammation oxidative stress subarachnoid hemorrhage

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