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PCMD:A multilevel comparison database of intraand cross-species metabolic profiling in 530 plant species

Plant Communications 2024年第10期5卷 33-44页

作者： Yue Hu Yao Ruan Xin-Le Zhao Feng Jiang Dongxu Liu Qiang Zhu Qing-Ye Zhang Qing-Yong Yang National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070HubeiChina Hubei Key Laboratory of Agricultural Bioinformatics and Hubei Engineering Technology Research Center of Agricultural Big Data College of InformaticsHuazhong Agricultural UniversityWuhan 430070China Yazhouwan National Laboratory Sanya 572024China

comparative metabolomics plays a crucial role in investigating gene function,exploring metabolite evolution,and accelerating crop genetic ***,a systematic platform for intra-and crossspecies comparison of metabolites is currently ***,we report the Plant comparative Metabolome Database(PCMD;http://***/PCMD),a multilevel comparison database based on predicted metabolic profiles of 530 plant *** PCMD serves as a platform for comparing metabolite characteristics at various levels,including species,metabolites,pathways,and biological *** database also provides a number of user-friendly online tools,such as species comparison,metabolite enrichment,and ID conversion,enabling users to perform comparisons and enrichment analyses of metabolites across different *** addition,the PCMD establishes a unified system based on existing metabolite-related databases by standardizing metabolite *** PCMD is the most speciesrich comparative plant metabolomics database currently available,and a case study demonstrates its ability to provide new insights into plant metabolic diversity.

关键词： comparative metabolomics plant database multilevel comparison metabolite characteristics

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Elucidating the interaction of kansui and licorice by comparative plasma/tissue metabolomics and a heatmap with relative fold change

Elucidating the interaction of kansui and licorice by compar...

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2019中国中西医结合学会临床药理与毒理专业委员会第三届学术研讨会

作者： Yan-Yan Chen Juan Shen Yu-Ping Tang Jin-Gao Yu Jing Wang Shi-Jun Yue Jie Yang Jia-Qian Chen Li-Mei Feng Zhen-Hua Zhu Wei-Wei Tao Li Zhang Jin-Ao Duan Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility Shaanxi University of Chinese Medicine Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization Nanjing University of Chinese Medicine

Objective Although compatibility is highly advocated in traditional Chinese medicine (TCM), inappropriate combination of some herbs may reduce the therapeutic action and even produce toxic effects. Kansui and licorice, one of TCM "Eighteen Incompatible Medicaments", are the most representative cases of improper herbal combination, which may still be applied simultaneously with given conditions. However, the potential mechanism of their compatibility and incompatibility is unclear. Method In the present study, a comparative plasma/tissue metabolomics and a heatmap with relative fold change approach was used to elucidate the interaction of kansui and licorice on malignant pleural effusion(MPE) rats. MPE rats were given two different ratios of kansui and licorice, representing their compatibility and incompatibility respectively, then metabolic changes in plasma and tissues samples of liver, heart and kidney of different groups were assessed. Result Totally 57 metabolites were filtered and identified from plasma and tissue metabolome in MPE model, including 19 in plasma, 15 in heart, 18 in liver, and 21 in kidney. An interactive heat map with relative fold change was created to improve our ability of exploring complex metabolomics data of herb-herb interaction. On the basis of relative contribution values on the heat map of biomarkers, glycocholic acid, prostaglandin F2 a, dihydroceramide and sphinganine were screened out as the principal alternative biomarkers of compatibility group, and sphinganine, dihydroceramide, arachidonic acid, leukotriene B4, acetoacetic acid and linoleic acid were screened out as those of incompatibility group. And by calculating the values of biomarkers in each tissue, liver was identified as the compatible target organ, while heart, liver, and kidney were identified as the incompatible target organs. Furthermore, pathways of primary bile acid biosynthesis and sphingolipid metabolism were constructed as the most important pathways for compat

关键词： comparative metabolomics Kansui Licorice Incompatibility

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