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双相、精神分裂患者的孩子,和属于他们的花园

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中国慈善家 2024年第1期 142-149页

作者：龚怡洁不详

对于专业选择,刚上大学的邱月给出了一个惊人的理由。“X光片里,我妈妈的头部有一条裂痕。我想通过学医学影像,看一下这个裂痕,到底是什么原因形成的。”他说。邱月的妈妈,是一位精神分裂症患者。像邱月这样的孩子,医学上对他们有一个... 详细信息

对于专业选择,刚上大学的邱月给出了一个惊人的理由。“X光片里,我妈妈的头部有一条裂痕。我想通过学医学影像,看一下这个裂痕,到底是什么原因形成的。”他说。邱月的妈妈,是一位精神分裂症患者。像邱月这样的孩子,医学上对他们有一个专门的定义:compI,展开就是Children of Parents with Mental Ilness,即精神类疾病患者的子女们。

关键词：精神分裂患者精神分裂症患者精神类疾病医学影像 X光片 comp 裂痕

Altered Expression of comp,Collagen 1,and MMP9 in Pelvic Organ Prolapse

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Biomedical and Environmental Sciences 2023年第10期36卷 979-982页

作者： CHEN Yi Fei XU Hai Nan DUAN Yi Nan XIA Zhi Jun Department of Obstetrics and Gynecology Shengjing Hospital of China Medical UniversityShenyang 110004LiaoningChina Department of Obstetrics and Gynecology Liaoning Province Hospital for Women and ChildrenShenyang 110004LiaoningChina Department of Gynecology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200090China

Female pelvic organ prolapse(POP)is a common disorder that affects the quality of life of women considerably.Studies in China have reported a 9.6%prevalence of symptomatic POP in adult women[1],with a higher prevalenc... 详细信息

关键词： Collagen MMP9 comp POP

Subcarrier BD with Cooperative Communication for MIMO-NOMA System

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computers, Materials & Continua 2022年第9期72卷 5807-5821页

作者： Jung-In Baik Ji-Hwan Kim Beom-Sik Shin Ji-Hye Oh Hyoung-Kyu Song Department of Information and Communication Engineering and Convergence for Intelligent DroneSejong UniversitySeoul05006Korea

With the rapid evolution of Internet of things(IoT),many edge devices require simultaneous connection in 5G communication era.To afford massive data of IoT devices,multiple input multiple output non-orthogonal multiple access(MIMO-NOMA)method has been considered as a promising technology.However,there are numerous drawbacks due to error propagation and inter-user interferences.Therefore,proposed scheme aims to improve the reliability of the MIMO-NOMA system with digital beamforming and intracluster cooperative multi point(comp)to efficiently support IoT system.In the conventional MIMO-NOMA system,user entities are grouped into clusters.Block diagonalization(BD)is applied to efficiently eliminate the inter-cluster interference of the MIMO-NOMA system.However,since the channel path of the data stream from a single antenna to a single cluster doesn’t hold other cluster’s data,the system can’t fully utilize the selective subcarrier channel states.It indicates that there can be better channel paths for a data stream at a certain subcarrier index.Therefore,proposed scheme allocates data streams to antennas adaptively considering selective channel states.Additionally,intra-cluster comp method is adjusted to enhance the reliability of the system in the clusters.The simulation results show that the proposed scheme improves BER and throughput performance compared to the conventional MIMO-NOMA system.

关键词： 5G MIMO-NOMA comp BD interference

A novel mutation in exon 11 of comp gene in a Chinese family with pseudoachondroplasia

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Genes & Diseases 2019年第1期6卷 47-55页

作者： Jun Chen Wenbing Zhang Jinzhou He Run Zhang Yinqiang Cao Xing Liu Department of Orthopedic Chongqing Children’s HospitalChongqing Medical UniversityNo.136 of Zhong Shan Er LuChongqing400014China Molecular Oncology Laboratory Department of Orthopaedic SurgeryThe University of Chicago Medical CenterChicagoILUSA

Pseudoachondroplasia(PSACH)is a relatively common skeletal dysplasia characterized by disproportionate short stature,joint laxity,early-onset osteoarthrosis,and dysplasia of the spine,epiphysis,and metaphysis.It is known as an autosomal dominant disease which results exclusively from mutations in the gene for Cartilage Oligomeric Matrix Protein(comp).We have identified a five year old Chinese boy who was diagnosed as pseudoachondroplasia according to clinical manifestations and X-ray symptoms.His mother seems like another effected individual because of the apparent short stature.Genomic DNA was extracted from peripheral blood lymphocytes.DNA sequencing analysis of the comp gene revealed a heterozygous mutation(c.1219 T>C,p.Cys407Arg)in the patient.His mother was also affected with the same genetic change.Mutations in comp gene is proved to change the Cartilage Oligomeric Matrix Protein.This missense mutation(c.1219 T>C)has not been reported before and it is not belongs to polymorphism sites.Our results extend the spectrum of mutations in comp gene leading to pseudoachondroplasia.

关键词： comp Novel mutation Skeletal dysplasia Pseudoachondroplasia Therapy

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国家药监局批准可伐利单抗注射液上市

中国处方药 2024年第5期22卷 I0001-I0001页

近日,国家药品监督管理局通过优先审评审批程序批准Roche Pharma(Schweiz)AG申报的可伐利单抗注射液(商品名:派圣凯/Piasky)上市。这是该药品在全球所有国家中的首次获批。用于未接受过补体抑制剂治疗的阵发性睡眠性血红蛋白尿症(PNH)... 详细信息

近日,国家药品监督管理局通过优先审评审批程序批准Roche Pharma(Schweiz)AG申报的可伐利单抗注射液(商品名:派圣凯/Piasky)上市。这是该药品在全球所有国家中的首次获批。用于未接受过补体抑制剂治疗的阵发性睡眠性血红蛋白尿症(PNH)成人和青少年(≥12岁)患者。此次获批是基于两项Ⅲ期临床研究(COMMODORE 3,COMMODRE 2)和一项Ⅰ/Ⅱ期支持性研究(compOSER)的结果。

关键词：阵发性睡眠性血红蛋白尿症补体抑制剂 Roche PNH Ⅲ期临床研究 comp 优先审评注射液

The role of ADAMTSs in arthritis

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Protein & Cell 2010年第1期1卷 33-47页

作者： Edward A.Lin Chuan-Ju Liu Department of Orthopaedic Surgery New York University School of MedicineNew YorkNY 10003USA Department of Cell Biology New York University School of MedicineNew YorkNY 10016USA

The ADAMTS(a disintegrin and metalloproteinase with thrombospondin motifs)family consists of 19 proteases.These enzymes are known to play important roles in development,angiogenesis and coagulation;dysregulation and mutation of these enzymes have been implicated in many disease processes,such as inflammation,cancer,arthritis and atherosclerosis.This review briefly summarizes the structural organization and functional roles of ADAMTSs in normal and pathological conditions,focusing on members that are known to be involved in the degradation of extracellular matrix and loss of cartilage in arthritis,including the aggrecanases(ADAMTS-4 and ADAMTS-5),ADAMTS-7 and ADAMTS-12,the latter two are associated with cartilage oligomeric matrix protein(comp),a component of the cartilage extracellular matrix(ECM).We will discuss the expression pattern and the regulation of these metalloproteinases at multiple levels,including their interaction with substrates,induction by pro-inflammatory cytokines,protein processing,inhibition(e.g.,TIMP-3,alpha-2-macroglobulin,GEP),and activation(e.g.,syndecan-4,PACE-4).

关键词： ADAMTS metalloproteinase aggrecan comp arthritis

Low-complexity SAGE-based MMSE channel estimation for comp multi-user systems

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The Journal of China Universities of Posts and Telecommunications 2012年第5期19卷 26-31,38页

作者： LI Xiao-hui WANG Xin HEI Yong-qiang State Key Laboratory of Integrated Services Networks Xidian UniversityXi'an 710071China

Coordinated multiple point （comp） transmission/reception has been investigated recently as a promising technology to increase the cell-edge user performance of long term evolution-advanced （LTE-A）, and channel estimation is a crucial technology for comp systems. In this paper, we consider a reduced-complexity minimum mean square error （MMSE） channel estimator for comp systems. The estimator uses space alternating generalized expectation maximization （EM）（SAGE） algorithm to avoid the inverse operation of the joint MMSE estimator. In the proposed scheme, the base stations （BSs） in the comp system estimate the channels of all the coordinated users serially and iteratively. We derive the SAGE-based estimators and analyze complexity. Simulation results verify that the performance of the proposed algorithm is close to the joint MMSE estimation algorithm while reducing the complexity greatly.

关键词： comp multiple user SAGE MMSE channel estimation

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基于comp的5G免许可频段通信协调调度

武汉大学学报（工学版） 2023年第7期56卷 879-884页

作者：杨可心陈琪美江昊周浩武汉大学电子信息学院湖北武汉430072

为了应对未来5G系统中不断增加的无线设备带来的频谱稀缺、干扰严重、系统性能骤减等问题,提出一种基于协作多点传输(coordinated multi-point,comp)机制的免许可频段新空口(new radio-unlicensed,NR-U)协调调度方案。通过引入基于空间... 详细信息

为了应对未来5G系统中不断增加的无线设备带来的频谱稀缺、干扰严重、系统性能骤减等问题,提出一种基于协作多点传输(coordinated multi-point,comp)机制的免许可频段新空口(new radio-unlicensed,NR-U)协调调度方案。通过引入基于空间复用的先听后说(listen-before-talk,LBT)机制,实现免许可频段内NR-U与WiFi系统的和谐共存。此外,针对多个NR-U基站(base station,BS)在免许可频段的同信道干扰,设计了一个用户调度和波束协调的联合优化问题,采用分式规划和整数替换方法对其进行简化,并提出了交替方向乘子法和块坐标更新(alternating direction method of multipliers and block coordinate update,ADMM-BCU)融合算法来找到次优解,最终实现免许可频段内NR-U BS之间的协调传输。仿真结果证明,所提出的协调调度方案能够有效提升系统性能。

关键词： 5G NR-U 免许可频段空间复用 comp

Performance Evaluation with Improved Receiver Design for Asynchronous Coordinated Multipoint Transmissions

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Chinese Journal of Electronics 2016年第2期25卷 372-378页

作者： CAO Yuan WEN Yinghong MENG Xiangyang XU Wei National Engineering Research Center of Rail Transportation Operation and Control System. Beijing Jiaotong University School of Electronic and Information Engineering Beijing Jiaotong University National Mobile Communications Research Lab. Southeast University

Joint transmission is one of the ma jor transmission schemes in Coordinated multipoint(Co MP)transmission/reception systems for Long term evolutionadvanced(LTE-A). Due to different distances between User equipments(UE) and Base stations(BS), signals are not able to arrive at the receiver with perfect synchronization, which implies that the reception at UE is asynchronous. This paper presents an evaluation on asynchronous UE reception in multi-cell downlink joint transmission systems using our LTE-based Co MP simulator.Then, due to asynchronous reception, we propose an improved reception strategy to mitigate the interference which compensate for Rx timing difference on Joint transmission(JT) Co MP systems. Simulation results show that the per-subband global precoding scheme widely used in the Co MP system is considerably sensitive to asynchronous reception since the performance is dominated by the subcarrier used for precoding vector calculation. It is verified that our proposed solution is able to achieve significant improvements under asynchronous reception.

关键词： Joint transmission Asynchronous reception Global precoding comp