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A scoping review on the field validation and implementation of rapid diagnostic tests for vector-borne and other infectious diseases of poverty in urban areas

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Infectious diseases of Poverty 2018年第1期7卷 879-896页

作者： Lyda Osorio Jonny Alejandro Garcia Luis Gabriel Parra Victor Garcia Laura Torres Stephanie Degroote Valery Ridde Epidemiology and Population Health Research Group School of Public HealthUniversidad del ValleCalle 4B No.36-00 Edif 118 Escuela de Salud PúblicaUniversidad del Valle Campus San FernandoCaliColombia School of Medicine Universidad del ValleCaliColombia University of Montreal Public Health Research Institute(IRSPUM) MontrealCanada French Institute for Research on Sustainable Development(IRD) Paris Descartes UniversityPopulation and Development Center(CEPED)UniversiteParis Sorbonne CiteNational Institute of Health and Medical Research(INSERM)HealthVulnerabilities and Gender Relations South(SAGESUD)ParisFrance

Background:Health personnel face challenges in diagnosing vector-borne and other diseases of poverty in urban *** is a need to know what rapid diagnostic technologies are available,have been properly assessed,and are being implemented to improve control of these diseases in the urban *** paper characterizes evidence on the field validation and implementation in urban areas of rapid diagnostics for vector-borne diseases and other diseases of *** body:A scoping review was ***-reviewed and grey literature were searched using terms describing the targeted infectious diseases,diagnostics evaluations,rapid tests,and urban *** review was limited to studies published between 2000 and 2016 in English,Spanish,French,and *** and exclusion criteria were refined post hoc to identify relevant literature regardless of study design and geography.A total of 179 documents of the 7806 initially screened were included in the ***(n=100)and tuberculosis(n=47)accounted for the majority of studies that reported diagnostics performance,impact,and implementation *** studies,assessing mainly performance,were identified for visceral leishmaniasis(n=9),filariasis and leptospirosis(each n=5),enteric fever and schistosomiasis(each n=3),dengue and leprosy(each n=2),and Chagas disease,human African trypanosomiasis,and cholera(each n=1).Reported sensitivity of rapid tests was variable depending on several ***,specificities were high(>80%),except for schistosomiasis and *** and implementation outcomes,mainly acceptability and cost,followed by adoption,feasibility,and sustainability of rapid tests are being evaluated in the *** to implementing rapid tests range from cultural to technical and administrative ***:Rapid diagnostic tests for vector-borne and other diseases of poverty are being used in the urban context with demonstrated impact on case ***

关键词： communicable diseases Diagnostic services Point-of-care testing Field evaluation Sensitivity and specificity Implementation Evaluation studies Urban health

Clinical diagnosis of severe COVID-19:A derivation and validation of a prediction rule

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World Journal of Clinical Cases 2021年第13期9卷 2994-3007页

作者： Ming Tang Xia-Xia Yu Jia Huang Jun-Ling Gao Fu-Lan Cen Qi Xiao Shou-Zhi Fu Yang Yang Bo Xiong Yong-Jun Pan Ying-Xia Liu Yong-Wen Feng Jin-Xiu Li Yong Liu Department of Critical Care Medicine Shenzhen Third People’s HospitalThe Second Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518114Guangdong ProvinceChina School of Biomedical Engineering Health Science CenterShenzhen UniversityShenzhen 518060Guangdong ProvinceChina Buddhism and Science Research Laboratory Centre of Buddhist StudiesThe University of Hong KongHong Kong 999077China Department of Critical Care Medicine Wuhan Third HospitalWuhan 433304Hubei ProvinceChina Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseaseShenzhen Third People's HospitalThe Second Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518114Guangdong ProvinceChina Department of Pediatrics Wuhan Asia General HospitalWuhan 430022Hubei ProvinceChina Department of Critical Care Medicine Southern University of Science and Technology HospitalShenzhen 518055Guangdong ProvinceChina Department of Critical Care Medicine The Second People's Hospital of ShenzhenShenzhen 518035Guangdong ProvinceChina Department of Critical Care Medicine The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Shenzhen Hospital Southern Medical UniversityShenzhen 518000Guangdong ProvinceChina

BACKGROUND The widespread coronavirus disease 2019(COVID-19)has led to high morbidity and ***,early risk identification of critically ill patients remains *** To develop predictive rules at the time of admission to identify COVID-19 patients who might require intensive care unit(ICU)*** This retrospective study included a total of 361 patients with confirmed COVID-19 by reverse transcription-polymerase chain reaction between January 19,2020,and March 14,2020 in Shenzhen Third People’s *** logistic regression was applied to develop the predictive *** performance of the predictive model was externally validated and evaluated based on a dataset involving 126 patients from the Wuhan Asia General Hospital between December 2019 and March 2020,by area under the receiver operating curve(AUROC),goodness-of-fit and the performance matrix including the sensitivity,specificity,and precision.A nomogram was also used to visualize the *** Among the patients in the derivation and validation datasets,38 and 9 participants(10.5%and 2.54%,respectively)developed severe COVID-19,*** univariate analysis,21 parameters such as age,sex(male),smoker,body mass index(BMI),time from onset to admission(>5 d),asthenia,dry cough,expectoration,shortness of breath,asthenia,and Rox index<18(pulse oxygen saturation,SpO2)/(FiO2×respiratory rate,RR)showed positive correlations with severe *** multivariate logistic regression analysis,only six parameters including BMI[odds ratio(OR)3.939;95%confidence interval(CI):1.409-11.015;P=0.009],time from onset to admission(≥5 d)(OR 7.107;95%CI:1.449-34.849;P=0.016),fever(OR 6.794;95%CI:1.401-32.951;P=0.017),Charlson index(OR 2.917;95%CI:1.279-6.654;P=0.011),PaO2/FiO2 ratio(OR 17.570;95%CI:1.117-276.383;P=0.041),and neutrophil/lymphocyte ratio(OR 3.574;95%CI:1.048-12.191;P=0.042)were found to be independent predictors of *** factors were found to be significant risk f

关键词： COVID-19 communicable diseases Clinical decision rules Prognosis Nomograms

Balancing timeliness of reporting with increasing testing probability for epidemic data

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Infectious Disease Modelling 2022年第2期7卷 106-116页

作者： Alexander J.Pritchard Matthew J.Silk Simon Carrignon R.Alexander Bentley Nina H.Fefferman NIMBioS National Institute for Mathematical and Biological SynthesisUniversity of TennesseeKnoxvilleUSA Centre for Ecology and Conservation University of Exeter Penryn CampusUK Department of Anthropology University of TennesseeKnoxvilleUSA McDonald Institute for Archaeological Research University of CambridgeUK Ecology and Evolutionary Biology University of TennesseeKnoxvilleUSA Department of Mathematics University of TennesseeKnoxvilleUSA

Reporting of epidemiological data requires coordinated action by numerous agencies,across a multitude of logistical *** collated and reported information to inform direct interventions can be challenging due to associated *** can,however,occur indirectly through the public generation of concern,which facilitates adherence to protective *** utilized a coupled-dynamic multiplex network model with a communication-and disease-layer to examine how variation in reporting delay and testing probability are likely to impact adherence to protective behaviors,such as reducing physical *** concern mediated adherence and was informed by new-or active-case reporting,at the population-or *** received information from the communication layer:direct connections that were sick or adherent to protective behaviors increased their concern,but absence of illness eroded *** revealed that the relative benefit of timely reporting and a high probability of testing was contingent on how much information was already *** low rates of testing,increasing testing probability was of greater mitigating *** high rates of testing,maximizing timeliness was of greater ***-level reporting provided advanced warning of disease risk from nearby communities;but we explore the relative costs and benefits of delays due to scale against the assumption that people may prioritize community-level *** findings emphasize the interaction of testing accuracy and reporting timeliness for the indirect mitigation of disease in a complex social system.

关键词： Behavioral science communicable diseases Disease outbreaks Disease reporting Surveillance

Assessing the prevalence of young children living in households prepared for COVID-19 in 56 low-and middle-income countries

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Global Health Research and Policy 2022年第1期7卷 389-400页

作者： Chunling Lu Yiqun Luan Sara N.Naicker S.V.Subramanian Jere R.Behrman Jody Heymann Alan Stein Linda M.Richter Division of Global Health Equity Brigham&Women’s HospitalBostonMAUSA Department of Global Health&Social Medicine Harvard Medical SchoolBostonMAUSA The Heller School for Social Policy and Manage-ment Brandeis UniversityWalthamMAUSA DSI-NRF Centre of Excellence in Human Development University of WitwatersrandJohannesburgSouth Africa Harvard Center for Population and Development Studies CambridgeMAUSA Department of Social and Behavioral Sciences Harvard T.H.Chan School of Public HealthBostonMAUSA Center for Geographic Analysis Harvard UniversityCambridgeMAUSA Department of Economics University of PennsylvaniaPhiladelphiaPAUSA WORLD Policy Analysis Center University of CaliforniaLos AngelesLos AngelesCAUSA Department of Psychiatry University of OxfordOxfordUK MRC/Wits Rural Public Health and Health Transitions Research Unit(Agincourt) Faculty of Health SciencesSchool of Public HealthUniversity of the WitwatersrandJohannesburgSouth Africa Africa Health Research Institute DurbanKwaZulu-NatalSouth Africa

Background:The COVID-19 pandemic and governments’attempts to contain it are negatively affecting young children’s health and development in ways we are only beginning to understand and *** to the pandemic are driven largely by confining children and families to their *** study aims to assess the levels of and associated socioeconomic disparities in household preparedness for protecting young children under the age of five from being exposed to communicable diseases,such as COVID-19,in low-and middle-income countries(LMICs).Methods:Using data from nationally representative household surveys in 56 LMICs since 2016,we estimated the percentages of young children under the age of five living in households prepared for communicable diseases(e.g.,COVID-19)and associated residential and wealth disparities at the country-and *** was defined on the basis of space for quarantine,adequacy of toilet facilities and hand hygiene,mass media exposure at least once a week,and phone *** within countries were measured as the absolute gap in two domains—household wealth and residential area-and compared across regions and country income ***:The final data set included 766,313 children under age *** average,19.4%of young children in the 56 countries lived in households prepared for COVID-19,ranging from 0.6%in Ethiopia in 2016 to 70.9%in Tunisia in *** close to 90%of countries(50),fewer than 50%of young children lived in prepared *** children in rural areas or in the poorest households were less likely to live in prepared households than their ***:A large portion of young children under the age of five in LMICs were living in households that did not meet all preparedness guidelines for preventing COVID-19 and caring for patients at *** study highlights the need to ensure all families in LMICs have the means to prevent the spread of the pandemic or other communicable

关键词： Child Child development Developing Countries Preparedness COVID-19 Pandemics communicable diseases Quarantine Hand hygiene Toilet facilities Mass media Telephone

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中国防痨杂志

中国防痨杂志

作者：王黎霞

出版社：中国防痨协会

该刊为专业学术类期刊。全面报道我国结核病防治的方针政策与最新的科研成果及国内外结核病控制的最新发展动态。读者对象为从事结核病控制、临床、基础科研防痨工作者。

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Potential for broad-scale transmission of Ebola virus disease during the West Africa crisis:lessons for the Global Health security agenda

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Infectious diseases of Poverty 2017年第1期6卷 1419-1428页

作者： Eduardo A.Undurraga Cristina Carias Martin I.Meltzer Emily B.Kahn National Center for Emerging and Zoonotic Infectious diseases Centers for Disease Control and PreventionAtlantaGeorgiaUSA Present address:School of Government Pontificia Universidad Católica de ChileSantiagoRegión MetropolitanaChile

Background:The 2014-2016 Ebola crisis in West Africa had approximately eight times as many reported deaths as the sum of all previous Ebola *** outbreak magnitude and occurrence of multiple Ebola cases in at least seven countries beyond Liberia,Sierra Leone,and Guinea,hinted at the possibility of broad-scale transmission of *** text:Using a modeling tool developed by the US Centers for Disease Control and Prevention during the Ebola outbreak,we estimated the number of Ebola cases that might have occurred had the disease spread beyond the three countries in West Africa to cities in other countries at high risk for disease transmission(based on late 2014 air travel patterns).We estimated Ebola cases in three scenarios:a delayed response,a Liberia-like response,and a fast response *** on our estimates of the number of Ebola cases that could have occurred had Ebola spread to other countries beyond the West African foci,we emphasize the need for improved levels of preparedness and response to public health threats,which is the goal of the Global Health Security *** estimates suggest that Ebola could have potentially spread widely beyond the West Africa foci,had local and international health workers and organizations not committed to a major response *** results underscore the importance of rapid detection and initiation of an effective,organized response,and the challenges faced by countries with limited public health *** lessons for strengthening local public health systems in countries at high risk of disease transmission include increasing health personnel,bolstering primary and critical healthcare facilities,developing public health infrastructure(*** capacity),and improving disease *** stronger local public health systems infectious disease outbreaks would still occur,but their rapid escalation would be considerably less likely,minimizing the impact of public health threats such as Eb

关键词： Ebola virus Global health Transmission Epidemics Viruses communicable diseases Western Africa Guinea Liberia Sierra Leone

Prevention of Gastrointestinal Pathologies: Comparative Study of the Microbial Flora of the Sanitary Surfaces of the Toilets of Students and Staff of the Félix Houphouët-Boigny University

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Open Journal of Medical Microbiology 2020年第3期10卷 129-138页

作者： N’gbesso Jean-Paul N’gbesso Beudje Félicité Okoubo Née A. Nicaise N’guessan Mambey Serge Juili Landry A. Arra Allou Aime Constantin Ahoua Biology and Health Laboratory UFR Environment Vectors and Parasites Université Félix Houphou&#235 t-Boigny Abidjan C&#244 te d’Ivoire National Laboratory for Agricultural Development Support (LANADA)/Bacteriology Service Abidjan C&#244 te d’Ivoire Direction de l’Hygiène Publique et de Santé Environnement (DHPSE) Abidjan C&#244 te d’Ivoire University Center for Research and Application in Remote Sensing Félix Houphou&#235 t-Boigny University Abidjan C&#244 te d’Ivoire Institute of Tropical Geography Félix Houphou&#235 t-Boigny University Abidjan C&#244 te d’Ivoire

Pathologies transmissible by hand such as gastrointestinal pathologies constitute a real public health problem, especially in sub-Saharan Africa where hygienic conditions are precarious. This study took place at Félix Houphouët-Boigny University from April to August 2018. The samples were taken from toilet surfaces such as doorknobs, tap heads, flush push buttons and seats WC. A total of three hundred and sixty-eight (368) samples were obtained, including 170 from the staff toilets and 198 from the student toilets. The results revealed the presence of total coliforms, Escherichia spp and Salmonella spp. The surfaces of student toilets were the most contaminated surfaces. The presence of entero-bacteria on the contact surfaces of the toilets of the Félix Houphouët-Boigny university represents a health risk for the university population.

关键词： communicable diseases Hand Hygiene Enterobacteriaceae Toilet University

Brazilian Spotted Fever Mortality Profile: 2018 to 2022

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Advances in Infectious diseases 2023年第3期13卷 498-507页

作者： Danielle Satie Kassada Paula Cristina Pereira da Costa Gabriel Borba de Castro Isabela Cristina Nogueira Henrique Ceretta Oliveira Dalvani Marques Department of Public Health School of Nursing University of Campinas Sao Paulo Brazil Undergraduate Student at the School of Nursing University of Campinas Sao Paulo Brazil Master’s Student at the School of Nursing University of Campinas Sao Paulo Brazil Statistician at the School of Nursing University of Campinas Sao Paulo Brazil

Background: Spotted Fever (SF) is an acute febrile zoonosis of variable severity that typically occurs in an endemic manner with worldwide distribution. Considering that SF is a disease of significant public health importance, this study aims to identify the mortality profile due to SF in Brazil from 2018 to 2022. Methods: Quantitative and descriptive cross-sectional approach. Data were collected from Brazilian Spotted Fever (BSF) cases registered in the Notifiable diseases Information System (SINAN-DATASUS) across all regions of Brazil. The data collected includes information on the following variables: year of symptom, evolution, sex, race, environment of infection, region of notification, and age group. Subsequently, the data was entered into Microsoft Excel to create tables and graphs. The chi-square test was then applied to statistically analyze the associations between qualitative variables. A modified Poisson regression model with robust variance was constructed to analyze the age group data and determine which categories had different probabilities of death. The results show the estimates obtained for prevalence ratios, as well as their respective confidence intervals and p-values. The statistical software SAS version 9.4 was used to perform the analysis and a significance level of 5% was considered. Results: From 2018 to 2022, a total of 1126 cases of BSF were reported. Out of these cases, 59.3% (668) were cured, 32.4% (364) resulted in death, 1.1% (13) died from other causes and 7.2% (81) had no recorded outcome. Regarding the region with the highest death rate, the Southeast region led with 99.45% (362) of cases, followed by the Northeast region with 0.45% (2). As for the age group, the majority (63.7%) fell between the ages of 20 and 59 years old. In terms of race/color, 52.7% of the population identified as white. Regarding the contamination environment, 39.3% were in leisure areas. The outcome of death by BSF showed statistically significant associatio

关键词： Brazilian Spotted Fever Mortality communicable diseases Disease Notification

Capacity Development of National Reference Centers (NRC) to Face the Challenges of Emerging Infections in Côte d’Ivoire

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Open Journal of Internal Medicine 2023年第3期13卷 181-208页

作者： Diané Kouao Maxime Adjogoua Edgard Valery Coulibaly Ngolo Antoine Marie-David Kadjo A. Hervé N’guessan Kouassi Raymond Sylla Yahaya Anne Blessa Jean Claude Beourou Sylvain Guessennd-Kouadio Aya Nathalie Dosso Mireille Tiembré Issiaka Pasteur Institute of Cô te d’Ivoire Abidjan C&ocircte d’Ivoire Biological Resource Center Abidjan C&ocircte d’Ivoire Epidemic Virus Department Abidjan C&ocircte d’Ivoire Molecular Biology Platform Abidjan C&ocircte d’Ivoire Mycobacterium Tuberculosis Unit Abidjan C&ocircte d’Ivoire Clinical Bacteriology Unit Abidjan C&ocircte d’Ivoire Department of Mycology Malariology Abidjan C&ocircte d’Ivoire Antibiotics Unit Abidjan C&ocircte d’Ivoire Department of Public Health UFR Medical Science Université Félix Houphou&eumlt-Boigny Abidjan C&ocircte d’Ivoire

Background: Some national and international strategies for the detection and prevention of emerging infectious diseases have been established across sectors. The capacity to carry out these tasks varies from country to country, and that remains largely undervalued. The Pasteur Institute of C?te d’Ivoire has created and implemented the capacity of national reference centers to fight against emerging and other infectious diseases. Objective: Show on the one hand the strategies used to develop the National Reference Centers and the IPCI and on the other hand the results obtained by performing these strategies. Method: Datas collection by documentary analysis (published scientific articles and grey literature) was done on Google Scholar, PUBMED and institutional reference documents. The documentary research was carried out to have a better understanding of strategies used to create and develop the NRCs in microbiology of communicable diseases. Results: Seven integrated strategies were launched: 1-training and workforce development;2-investigation of epidemics or public health events;3-strengthening laboratory epidemiological research;4-strengthening surveillance systems;5-improving communication with partners and stakeholders;6-building national and international collaborations;and 7-strengthening technical and technological platforms. In two decades, the number of researchers has risen from 10 in 2004 to ninety (90) in 2021, with 12 senior researchers and 32 junior researchers. A number of health service staff had attended a qualifying training course, 27 investigations into outbreaks and other public health events had been carried out, 18 short-term research projects had been launched, major surveillance programs and epidemiological research efforts on vector-borne, food-borne and nosocomial infections had begun, and several scientific manuscripts had been published or were edited in the writting press. Conclusion: The Ivorian experience shows that, with concerted eff

关键词： Evaluation communicable diseases National Reference Centerorlaboratorie Capacity Development Côte d’Ivoire