检索结果-南通市图书馆

Emerging systemic delivery strategies of oncolytic viruses:A key step toward cancer immunotherapy

Nano Research 2022年第5期15卷 4137-4153页

作者： Weiyue Ban Jianhuan Guan Hanwei Huang Zhonggui He Mengchi Sun Funan Liu Jin Sun Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Department of Surgical Oncology and General Surgery The First Hospital of China Medical UniversityKey Laboratory of Precision Diagnosis and Treatment of Gastrointestinal TumorsChina Medical UniversityMinistry of EducationShenyang 110016China

Oncolytic virotherapy(OVT)is a novel type of immunotherapy that induces anti-tumor responses through selective self-replication within cancer cells and oncolytic virus(OV)-mediated ***,talimogene laherparepvec(T-Vec)developed by the Amgen company in 2015,is the first FDA-approved OV product to be administered via intratumoral injection and has been the most successful OVT ***,the systemic administration of OVs still faces huge challenges,including in vivo pre-existing neutralizing antibodies and poor targeting delivery ***,state-of-the-art progress has been made in the development of systemic delivery of OVs,which demonstrates a promising step toward broadening the scope of cancer immunotherapy and improving the clinical efficacy of OV ***,this review describes the general characteristics of OVs,focusing on the action mechanisms of OVs as well as the advantages and disadvantages of *** emerging multiple systemic administration approaches of OVs are summarized in the past five *** addition,the combination treatments between OVT and traditional therapies(chemotherapy,thermotherapy,immunotherapy,and radiotherapy,etc.)are *** but not least,the future prospects and challenges of OVT are also discussed,with the aim of facilitating medical researchers to extensively apply the OVT in the cancer therapy.

关键词： oncolytic virotherapy oncolytic viruses talimogene laherparepvec systemic administration combination treatments

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncolytic virus-based hepatocellular carcinoma treatment:Current status,intravenous delivery strategies,and emerging combination therapeutic solutions

引用

Asian Journal of Pharmaceutical Sciences 2023年第1期18卷 4-26页

作者： Xinguo Li Xiaonan Sun BingyuanWang Yiling Li Jing Tong The First Hospital of China Medical University Shenyang 110001China The 4th People’s Hospital of Shenyang Shenyang 110031China

Current treatments for advanced hepatocellular carcinoma(HCC)have limited success in improving patients’quality of life and prolonging life *** clinical need for more efficient and safe therapies has contributed to the exploration of emerging ***,there has been increased interest in oncolytic viruses(OVs)as a therapeutic modality for *** undergo selective replication in cancerous tissues and kill tumor ***,pexastimogene devacirepvec(Pexa-Vec)was granted an orphan drug status in HCC by the *** and Drug Administration(FDA)in ***,dozens of OVs are being tested in HCC-directed clinical and preclinical *** this review,the pathogenesis and current therapies of HCC are ***,we summarize multiple OVs as single therapeutic agents for the treatment of HCC,which have demonstrated certain efficacy and *** carrier cell-,bioengineered cell mimetic-or nonbiological vehicle-mediated OV intravenous delivery systems in HCC therapy are *** addition,we highlight the combination treatments between oncolytic virotherapy and other ***,the clinical challenges and prospects of OV-based biotherapy are discussed,with the aim of continuing to develop a fascinating approach in HCC patients.

关键词： Oncolytic viruses(OVs) OV intravenous delivery systems combination treatments Advanced hepatocellular carcinoma (HCC) Pexa-Vec

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：