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Programmed death-ligand 1 expression in the tumour stroma of colorectal liver oligometastases and its association with prognosis after liver resection

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Gastroenterology Report 2021年第5期9卷 443-450,I0002页

作者： Jian-Hong Peng Yi Tai Yi-Xin Zhao Bao-Jia Luo Qing-Jian Ou Zhi-Zhong Pan Lin Zhang Zhen-Hai Lu Department of colorectal Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine GuangzhouGuangdongP.R.China Department of Clinical Laboratory Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China

Background The clinical value of programmed death-ligand 1(PD-L1)expression in colorectal liver oligometastases(CLOs)remains *** study aimed to detect PD-L1 in the microenvironment of CLOs and determine its association with patient *** We collected 126 liver-resection specimens from CLO patients who underwent curative liver resection between June 1999 and December ***(IHC)was performed to assess PD-L1 expression in paraffinembedded *** survival(OS)and recurrence-free survival(RFS)were analysed using the Kaplan–Meier method and log-rank *** PD-L1 was mainly expressed in the stroma of liver *** with high PD-L1 expression had a higher proportion of clinical-risk scores(CRSs)of 2–4(67.7%vs 40.4%;P=0.004).With a median 58-month follow-up,patients with high PD-L1 expression had a significantly lower 3-year OS rate(65.5%vs 92.7%;P=0.001)and 3-year RFS rate(34.7%vs 83.8%;P<0.001)than patients with low PD-L1 *** Cox analysis demonstrated that high PD-L1 expression(hazard ratio[HR]=3.581;95%confidence interval[CI]2.301–9.972;P=0.015),CRS 2–4(HR=6.960;95%CI 1.135–42.689;P=0.036)and increased preoperative CA19-9(HR=2.843;95%CI 1.229–6.576;P=0.015)were independent risk factors for *** PD-L1 expression(HR=4.815;95%CI 2.139–10.837;P<0.001)and lymph-node metastasis(HR=2.115;95%CI 1.041–4.297;P=0.038)were independent risk factors for *** This study found that PD-L1 was commonly expressed in the tumour stroma of CLOs and high PD-L1 expression was associated with poor prognosis.

关键词： PD-L1 colorectal liver oligometastases expression prognosis

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