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Brewers' rice modulates oxidative stress in azoxymethanemediated colon carcinogenesis in rats

World Journal of Gastroenterology 2015年第29期21卷 8826-8835页

作者： Bee Ling Tan Mohd Esa Norhaizan Ky Huynh Swee Keong Yeap Hamzah Hazilawati Karim Roselina Department of Nutrition and Dietetics Faculty of Medicine and Health Sciences Universiti Putra Malaysia Research Centre of Excellent Nutrition and Non-Communicable Diseases Faculty of Medicine and Health Sciences Universiti Putra Malaysia Laboratory of Molecular Biomedicine Institute of Bioscience Universiti Putra Malaysia Department of Cell and Molecular Biology Faculty of Biotechnology and Biomolecular Sciences Universiti Putra Malaysia Department of Veterinary Pathology and Microbiology Faculty of Veterinary Medicine Universiti Putra Malaysia Department of Food Technology Faculty of Food Science and Technology Universiti Putra Malaysia

AIM: To investigate the mechanistic action of brewers' rice in regulating the Wnt/nuclear factor-kappa B(NF-κB)/Nrf2-signaling pathways during colon carcinogenesis in male Sprague-Dawley ***: Male Sprague-Dawley rats were randomly divided into the following five groups(six rats in each group):(G1) normal,(G2) azoxymethane(AOM) alone,(G3) AOM + 10%(weight(w)/weight(w)) brewers' rice,(G4) AOM + 20%(w/w) brewers' rice, and(G5) AOM + 40%(w/w) brewers' rice. They were intraperitoneally administered 15 mg/kg body weight of AOM in saline once weekly over a twoweek period and treated with an American Institute of Nutrition(AIN)-93 G diet containing 10%, 20%, and 40%(w/w) brewers' rice. The m RNA levels of glycogen synthase kinase 3β(GSK 3β), β-catenin, key inflammation markers, nuclear factor E2-related factor 2(Nrf2), and heme oxygenase-1(HO-1)-dependent transcriptional activity were assessed by quantitative real-time polymerase chain reaction analyses. The colon superoxide dismutase, malondialdehyde, and nitric oxide levels were also analyzed to assess the antioxidant effect of these treatments. The results were analyzed using one-way analysis of variance(ANOVA), and a P value of < 0.05 was considered ***: The overall analyses demonstrated that the dietary administration of brewers' rice in AOM-induced rat colon carcinogenesis resulted in the transcriptional upregulation of GSK 3β, inducible nitric oxide synthase(i NOS), Nrf2, and HO-1. We discovered that the dietary administration of brewers' rice downregulated the β-catenin and NF-κB m RNA levels. A significant reduction in β-catenin expression was found in the groups administered with 20%(0.611 ± 0.034) and 40%(0.436 ± 0.045)(w/w) brewers' rice compared with that of the group treated with AOM alone(1.000 ± 0.064)(P < 0.05). The NF-κB expression was significantly lower between the AOM-alone group(1.000 ± 0.048) and those groups fed with diets containing 10%(w/w) brewers' rice(0.255 ± 0.022), 20%

关键词： Brewers' rice Nuclear factor-kappa B coloncancer β-catenin nuclear factor E2-related factor 2

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Protective links between vitamin D,inflammatory boweldisease and colon cancer

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World Journal of Gastroenterology 2016年第3期22卷 933-948页

作者： Stacey Meeker Audrey Seamons Lillian Maggio-Price Jisun Paik Department of Comparative Medicine University of WashingtonSeattleWA 98195United States

Vitamin D deficiency has been associated with a wide range of diseases and multiple forms of cancer including breast, colon, and prostate cancers. Relatively recent work has demonstrated vitamin D to be critical in immune function and therefore important in inflammatory diseases such as inflammatory bowel disease(IBD). Because vitamin D deficiency or insufficiency is increasingly prevalent around the world, with an estimated 30%-50% of children and adults at risk for vitamin D deficiency worldwide, it could have a significant impact on IBD. Epidemiologic studies suggest that low serum vitamin D levels are a risk factor for IBD and colon cancer, and vitamin D supplementation is associated with decreased colitis disease activity and/or alleviated symptoms. Patients diagnosed with IBD have a higher incidence of colorectal cancer than the general population, which supports the notion that inflammation plays a key role in cancer development and underscores the importance of understanding how vitamin D influences inflammation and its cancer-promoting effects. In addition to human epidemiological data, studies utilizing mouse models of colitis have shown that vitamin D is beneficial in preventing or ameliorating inflammation and clinical disease. The precise role of vitamin D on colitis is unknown; however, vitamin D regulates immune cell trafficking and differentiation, gut barrier function and antimicrobial peptide synthesis, all of which may be protective from IBD and colon cancer. Here we focus on effects of vitamin D on inflammation and inflammation-associated colon cancer and discuss the potential use of vitamin D for protection and treatment of IBD and colon cancer.

关键词： Vitamin D Inflammatory bowel disease Colitis Colon cancer Inflammation-associated coloncancer Mouse models

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