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Developments for collagen hydrolysates as a multifunctional antioxidant in biomedical domains

collagen and Leather 2023年第3期5卷 1-21页

作者： Guiya Deng Ke Huang Xianchao Jiang Kun Wang Zihao Song Yuchen Su Chengming Li Shuai Zhang Shiqi Wang Yaqin Huang Beijing Laboratory of Biomedical Materials Key Laboratory of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology)Ministry of EducationBeijing University of Chemical TechnologyBeijing 100029People's Republic of China School of Pharmacy Queen's University BelfastBelfast BT97BLUK Drug Research Program Division of Pharmaceutical Chemistry and TechnologyFaculty of PharmacyUniversity of Helsinki00014 HelsinkiFinland

Antioxidant collagen hydrolysates refers to the peptides mixture with antioxidant properties identified from hydrolyzed *** to its specific structural,biological and physicochemical properties,collagen hydrolysates have been explored as a multifunctional antioxidant in the biomedical *** this review,we summarize recent advances in antioxidant collagen hydrolysates ***,the preparation process of antioxidant collagen hydrolysates is introduced,including the production and separation *** the effects and the mechanisms of amino acid composition and collagen peptide structure on the antioxidant activity of collagen hydrolysates are ***,the applications of antioxidant collagen hydrolysates in biomedical domains are summarized,with critical discussions about the advantages,current limitations and challenges to be resolved in the future.

关键词： collagen hydrolysates Antioxidant Peptides Biomedical applications

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Osteogenic peptides in collagen hydrolysates:Stimulate differentiation of MC3T3-E1 cells viaβ1 integrin-FAK-ERK1/2 signaling pathway and Smad1 protein

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Food Bioscience 2022年第3期47卷 1368-1377页

作者： Yibo Liu Shiming Li Hui Liu Bo Li College of Food Science and Nutritional Engineering China Agricultural UniversityBeijing100083China

Our previous study demonstrated that orally administration of collagen hydrolysates from silver carp skin(SCH)could increase bone remodeling in chronologically aged ***,the active compounds and molecular mechanism were still *** this study,SCH showed strong activity in promoting osteogenic differentiation of MC3T3-E1 cells and the active components in it were separated by ultrafiltration and YMC ODS-A C18 *** then,a series of peptides containing potential osteogenic sequences were identified by LC-MS/MS and two novel peptides,GARGDKGETGEAGE(GE-14)and TGPRGPVGPA(TA-10),were synthesized for further *** results indicated that peptides GE-14 and TA-10 could promote the differentiation and mineralization of MC3T3-E1 cells by positively regulatingβ1 integrin-FAK-ERK1/2 and Smad1 pathway,which might be due to the RGD or GPR sequences in *** findings suggest that SCH has the potential to be developed as an effective diet supplement to prevent osteoporosis.

关键词： Silver carp skin collagen hydrolysates Osteogenic activity MC3T3-E1 β1 integrin

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Analysis of Molecular Weight Distribution and Antioxidant Activities of Cirrhinus molitorella Skin collagen hydrolysates

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Agricultural Science & Technology 2014年第5期15卷 738-741,800页

作者：霍建新白彩艳赵征山西晋中学院山西晋中030600 天津科技大学食品工程与生物技术学院天津300457

[Objective] The aim of this work was to identify molecular weight （MW） distribution and antioxidant activity of fish skin col agen hydrolysates. [Method] The MW distribution of hydrolysates was determined using both size exclusion chromatography and matrix-assisted laser desorption ionization time-of-flight mass spec-trometry （MALDI-TOF-MS）. Fish skin were treated by the alkaline protease 2709. [Result] The optional conditions for hyerolysis were time 3 h, temperature 55 ℃, pH 10.0, substrate concentration 80 g/L and E/S 4%. The results of both methods indi-cated that the molecular weight of col agen hydrolysates was from 400 to 1 800 Da, and the peptides’ molecular weight was less than 1 400 Da mostly. The reducing power and antioxidant/radical scavenging activity [1, 1-diphenyl-2-picryl-hydrazyl （DPPH） free radical scavenging activity] were determined. [Conclusion] The results reveal that the fishskin hydrolysate is a potential source of antioxidants.

关键词： collagen hydrolysates Cirrhinus molitorella Molecular weight distribution Alkaline protease 2709

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Study on Enzymatic Hydrolysis of Gadus morrhua Skin collagen and Molecular Weight Distribution of hydrolysates

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Agricultural Sciences in China 2009年第6期8卷 723-729页

作者： HUO Jian-xin ZHAO Zheng Jinzhong University Jinzhong 030600 P.R. China College of Food Engineering ＆ Biotechnology Tianjin University of Science ＆ Technology Tianjin 300457 P.R.China

Process parameters on enzymatic hydrolysis and molecular weight （MW） distribution of collagen hydrolysates from Gadus morrhua skin were investigated. The optimal process parameters were obtained by the single-factor and orthogonal experiments. The molecular weight distribution of hydrolysates was determined using both Sephadex G25 partition and high speed liquid chromatography electricity spray mass spectrum （HPLC-ESI-MS）. collagen hydrolysates were first gained by an alkaline protease ＂alcalase＂ for 3 h at temperature （50~C）, pH （10.0）, substrate concentration （75 g L-~）, and E/S （3%）. The molecular weight distribution of collagen hydrolysates ranged from 300 to 1 500 Da, and most of peptides were under 1 200 Da. Sephadex G25 partition and HPLC-ESI-MS should be successfully employed to determine the molecular weight distribution of collagen hydrolysates.

关键词： collagen hydrolysates Gadus morrhua molecular weight distribution alkaline protease

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