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Interaction between catechol-O-methyltransferase Val/Met polymorphism and cognitive reserve for negative symptoms in schizophrenia

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World Journal of Psychiatry 2024年第5期14卷 695-703页

作者： Wen-Peng Hou Xiang-Qin Qin Wei-Wei Hou Yun-Yi Han Qi-Jing Bo Fang Dong Fu-Chun Zhou Xian-Bin Li Chuan-Yue Wang Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders&National Center for Mental DisordersBeijing Anding HospitalCapital Medical UniversityBeijing 100088China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100069China

BACKGROUND cognitive reserve(CR)and the catechol-O-methyltransferase(COMT)Val/Met polymorphism are reportedly linked to negative symptoms in ***,the regulatory effect of the COMT genotype on the relationship between CR and negative symptoms is still *** To investigate whether the relationship between CR and negative symptoms could be regulated by the COMT Val/Met *** In a cross-sectional study,54 clinically stable patients with schizophrenia underwent assessments for the COMT genotype,CR,and negative *** was estimated using scores in the information and similarities subtests of a short form of the Chinese version of the Wechsler Adult Intelligence *** COMT Met-carriers exhibited fewer negative symptoms than Val *** the total sample,significant negative correlations were found between negative symptoms and information,*** between information,similarities and negative symptoms were observed in Val homozygotes only,with information and similarities showing interaction effects with the COMT genotype in relation to negative symptoms(information,β=-0.282,95%CI:-0.552 to-0.011,P=0.042;similarities,β=-0.250,95%CI:-0.495 to-0.004,P=0.046).CONCLUSION This study provides initial evidence that the association between negative symptoms and CR is under the regulation of the COMT genotype in schizophrenia.

关键词： Catechol-O-methyltransferase Val/Met polymorphism cognitive reserve Crystallized intelligence Negative symptoms Schizophrenia

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Mild cognitive impairment in Parkinson’s disease:a distinct clinical entity?

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Translational Neurodegeneration 2017年第1期6卷 225-231页

作者： Ming-Ching Wen Ling Ling Chan Louis C.S.Tan Eng King Tan Department of Research National Neuroscience InstituteSingaporeSingapore Department of Neurology National Neuroscience Institute11 Jalan Tan Tock SengSingapore 308433Singapore Department of Diagnostic Radiology Singapore General HospitalSingaporeSingapore Duke-NUS Medical School SingaporeSingapore

Background:Mild cognitive impairment in Parkinson’s disease(PD-MCI)is a common clinical *** its pathology and clinical features is important for early intervention before the onset of *** the past,variable definitions and differences in neuropsychological batteries generated divergent results of the affected cognitive *** body:The introduction of PD-MCI criteria by the Movement Disorders Society(MDS)Task Force provides a more uniform system for defining and measuring PD-MCI and may improve the validity of future ***-MCI is likely to be heterogeneous since it can coexist with Alzheimer’s disease and/or Lewy body pathologies in *** of neuropsychiatric disturbances,such as depression,anxiety and apathy,are associated with PD with or without *** addition,cognitive reserve formed by patients’unique life experiences may influence the outward cognitive performance despite the presence of the aforementioned pathogeneses and hence alter the diagnosis of ***:The overlap of cognitive impairment across different neurodegenerative diseases suggests that PD-MCI is likely to result from a mixture of complex pathophysiologies,rather than being a distinct pathologic *** MCI from other organic symptoms in PD would facilitate novel therapeutic strategies.

关键词： Mild cognitive impairment Parkinson’s disease Alzheimer disease Lewy body Neuropsychiatric comorbidities cognitive reserve

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Resting-state functional connectivity in lifelong musicians

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Psychoradiology 2023年第1期3卷 154-161页

作者： Cyrus Eierud Andrew Michael David Banks Edna Andrews Linguistics Program Duke UniversityDurhamNC 27708USA Duke Institute for Brain Sciences Duke UniversityDurhamNC 27708USA Department of Statistical Science Duke UniversityDurhamNC 27708USA Center for cognitive Neuroscience Duke UniversityDurhamNC 27708USA

Background:It has been postulated that musicianship can lead to enhanced brain and cognitive reserve,but the neural mechanisms of this effect have been poorly *** professional musicianship in conjunction with novel brain imaging techniques offers a unique opportunity to examine brain network differences between musicians and matched ***:In this study we aim to investigate how resting-state functional networks(FNs)manifest in lifelong active *** will evaluate the FNs of lifelong musicians and matched healthy controls using resting-state functional magnetic resonance ***:We derive FNs using the data-driven independent component analysis approach and analyze the functional network con-nectivity(FNC)between the default mode(DMN),sensory-motor(SMN),visual(VSN),and auditory(AUN)*** examine whether the linear regressions between FNC and age are different between the musicians and the control ***:The age trajectory of average FNC across all six pairs of FNs shows significant differences between musicians and *** show an increase in average FNC with age while controls show a decrease(P=0.013).When we evaluated each pair of FN,we note that in musicians FNC values increased with age in DMN–AUN,DMN–VSN,and SMN–VSN and in controls FNC values decreased with age in DMN–AUN,DMN–SMN,AUN–SMN,and SMN–***:This result provides early evidence that lifelong musicianship may contribute to enhanced brain and cognitive *** of this study are preliminary and need to be replicated with a larger number of participants.

关键词： resting-state fMRI lifelong musicianship default mode network sensory-motor network functional network connectivity cognitive reserve

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Influences of Age and Length of Education on rCBF-SPECT in Healthy Elderly:Diagnostic Implications for Dementia

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International Journal of Clinical Medicine 2011年第2期2卷 143-157页

作者： Torbjorn Sundstrom Anne Larsson Lars Nyberg Katrine Riklund Department of Radiation Sciences Diagnostic RadiologyUmea UniversityUmeaSweden Department of Radiation Sciences Radiation PhysicsUmea UniversityUmeaSweden

Background: Few previous studies have described other than age- and gender related changes in regional cerebral blood flow (rCBF) in healthy elderly. What is the influence of other common clinically relevant variables such as ache, education, MMSE, and smoking history? Purpose: To study rCBF in Swedish healthy elderly by single-photon emission computed tomography (SPECT) and evaluate the influence on rCBF of age, gender, education, MMSE, ache, and smoking with a focus on education in relation to the ‘cognitive reserve’. Methods: Healthy subjects (n = 45, 50 -75 y), sampled from a large longitudinal aging study took part in an extensive examination of health and memory, including cognitive testing and socio-economic survey. After injection of 99 mTc-hexamethylpropylene amine oxime (HMPAO) followed by SPECT the rCBF-SPECT images were analyzed using statistical parametric mapping (SPM). Results: Age-related decreases in uptake were seen in interhemispheric and interlobar regions. There was a positive rCBF correlation with education in the inferior frontal lobe and a higher uptake in the left temporal lobe in an age-gender-matched high education subgroup. Conclusion: The localization of the age related findings except for the medial temporal lobe differs markedly from typical dementia related findings. A reduction close to interhemispheric or interlobar space should always be related to chronological age. Education seems to have an influence on basal brain function at a resting-state condition. Knowledge of normal rCBF variations for variables such as age and education should be considered when making clinical diagnosis. The findings could be interpreted as further support for the theory of cognitive reserve.

关键词： Normal Material Dementia Alzheimer’s Disease 99 mTc-HMPAO rCBF-SPECT Brain Imaging Neuropsychology Regional Cerebral Blood Flow cognitive reserve

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