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cognitive deficits in patients with brain tumor

Chinese Medical Journal 2012年第14期125卷 2610-2617页

作者： SHEN Chao BAO Wei-min YANG Bo-jie XIE Rong CAO Xiao-yun LUAN Shi-hai MAO Ying Department of Neurosurgery Huashan Hospital Fudan UniversityShanghai 200040 China Institute of Neurology Fudan University Shanghai 200040 China

Objective To discuss the present status and progress of clinical research on the cognitive effects caused by different types of brain tumors and common treatments. Data sources The data used in this review were mainly from PubMed articles published in English from 1990 to Febuary 2012. Research terms were ＂cognitive deficits＂ or ＂cognitive dysfunction＂. Study selection Articals including any information about brain tumor related cognitive deficits were selected. Results It is widely accepted that brain tumors and related treatments can impair cognitive function across many domains, and can impact on patients＇ quality of life. Tumor localization, lateralization, surgery, drugs, radiotherapy and chemotherapy are all thought to be important factors in this process. However, some conflicting findings regarding brain tumor-related cognitive deficits have been reported. It can be difficult to determine the mechanism of these treatments, such as chemotherapy, antibiotics, antiepileptics, and steroids. Future research is needed to clarify these potential treatment effects. Conclusions cognitive function is important for patients with brain tumor. Much more focus has been paid on this field. It should be regarded as an important prognostic index for the patients with brain tumor, and neuropsychological tests should be used in regular examinations.

关键词： cognitive deficits, glioma meningeoma surgery radiotherapy, chemotherapy

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