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Neuroprotection of a cocktail therapy involving anti-intercellular adhesion molecule 1 antibody and insulin-like growth factor 1 in treatment of cerebral ischemia/reperfusion injury in cats Nuclear magnetic resonance examination and pathological validatio

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Neural Regeneration Research 2008年第12期3卷 1332-1337页

作者： Huaijun Liu Liqun Yan Yaping Hou Shuochun Wu Dan He Linfang Li Yankai Wu BoyuanHuang Fei Yang Department of Medical Imaging Second Hospital Hebei Medical University Shijiazhuang 050000 Hebei Province China

BACKGROUND： The pathophysiological mechanisms of ischemia are extremely complicated. It is difficult to confirm and maintain the therapeutic effects if only one neuroprotective agent is used. It is hypothesized that a cocktail therapy involving a combined application of neuroprotective agents is feasible and offers excellent therapeutic potential. OBJECTIVE： To evaluate the neuroprotective effects of a cocktail therapy of insulin-like growth factor 1 （IGF1） combined with anti-intercellular adhesion molecule 1 （ICAM1） antibody in the treatment of cerebral ischemia/reperfusion injury using medical imaging, pathology, and functional neurological deficit scoring techniques. DESIGN, TIME AND SETTING： This randomized, controlled, neuroimaging analysis of function and pathological observation was performed at the Laboratory of Molecular Imaging, Second Hospital, Hebei Medical University between September 2006 and December 2007. MATERIALS： Transient middle cerebral artery occlusion （MCAO） was induced in 24 healthy adult cats. Anti-ICAM1 antibody and IGF1 were sourced from the Shanghai Kangcheng Biological Product Co., Ltd., China. Stereotaxic apparatus was purchased from the Center for Medical Apparatus and Instruments, Shandong Liaocheng People＇s Hospital, China. The in situ apoptosis kit was provided by the Beijing Zhongshan Biotechnique Co., Ltd., China. METHODS： Twenty-four cat models of MCAO were randomly divided into four groups （n = 6）： control, IGF1, anti-ICAM 1 antibody and cocktail therapy. Following a 2-hour ischemia and subsequent lateral cerebral ventricular puncture, 100 μg IGFl（cerebral ventricular）, 100 μg anti-ICAM1 antibody （i.v.）, 50 μg IGFl（lateral cerebral ventricular）＋ 50 μg anti-ICAM1 antibody （i.v.）, and 100 μg physiological saline （i.v.） were administered to the IGF1, anti-ICAM1 antibody, cocktail therapy and control groups, respectively. On the following day, the same administration was performed again. MAIN OUTCOME MEASURES： Pathological observat

关键词： neuroprotection cocktail therapy ischemia/reperfusion magnetic resonance imaging

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Gold mineralized“hybrid nanozyme bomb”for NIR-Ⅱtriggered tumor effective permeation and cocktail therapy

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Chinese Chemical Letters 2024年第9期35卷 243-249页

作者： Ji Liu Dongsheng He Tianjiao Hao Yumin Hu Yan Zhao Zhen Li Chang Liu Daquan Chen Qiyue Wang Xiaofei Xin Yan Shen Department of Pharmaceutics State Key Laboratory of Nature MedicinesChina Pharmaceutical UniversityNanjing 210009China Wuxi Hequan Pharmaceutical Co. Ltd.Wuxi 214029China Beijing Xinghao Yingsheng Pharmaceutical Co. Ltd.Beijing 102609China School of Pharmacy Yantai UniversityYantai 264005China School of Pharmaceutical Science Nanjing Tech UniversityNanjing 211816China

Lung cancer is one of the most common malignant tumors with the fastest increase in the incidence rate and *** after maximum tumor resection assistance with a radiotherapy and chemotherapy combination,the recurrence of non-small cell lung cancer is still *** addition,low targeting efficiency and poor permeability of drug delivery systems strongly affect the therapeutic efficiency of anti-cancer drugs on non-small cell lung *** we designed a gemcitabine(GEM)loaded arginineglycine-aspartic acid-cysteine(RGDc)-modified gold mineralization“hybrid nanozyme bomb”(RGTG)to overcome those *** modification improved the active targeting of liposomes to the tumor tissues with the second near-infrared(NIR-Ⅱ)-triggered gold-shell disruption and GEM *** collapsed gold-shell particles with a smaller size could penetrate the tumor solid barrier and act as photothermal therapy(PTT)agents to improve PTT therapy and starvation therapy via generating gluconic acid and reactive oxygen species(ROS).Moreover,the resting reversal effect of gold particles on tumor fibroblasts can achieve accelerating tumor penetration of gold particles and *** to monotherapy,RGTG showed significant improvement in tumor inhibition,with a tumor volume reduction of 83%compared to the control group,which provides a promising tumor treatment platform for non-small cell lung cancer(NSCLC).

关键词： Gold mineralized Hybrid nanozyme bomb Starvation therapy cocktail therapy NSCLC

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