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Pathophysiology of acute graft-versus-host disease from the perspective of hemodynamics determined by dielectric analysis

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World Journal of Transplantation 2023年第6期13卷 379-390页

作者： Masayuki Nagasawa Department of Pediatrics Musashino Red Cross HospitalMusashino City 180-8610TokyoJapan Department of Pediatrics and Developmental Biology Tokyo Medical and Dental UniversityTokyo 113-8519TokyoJapan

BACKGROUND Numerous reports have demonstrated that the pathophysiology of graft-versushost disease(GVHD)during hematopoietic stem cell transplantation(HSCT)is closely related to vascular endothelial disorders and coagulation *** previously presented the discovery of a principle and the development of a novel instrument for measuring whole blood *** was achieved by assessing the variations in the dielectric properties of whole *** To investigate how GVHD affects the changes of dielectric properties of whole blood in patients with *** We examined the changes of dielectric properties of whole blood and erythrocyte proteins by sodium dodecyl sulfate-polyacrylamide gel electrophoresis sequentially in patients with HSCT and compared it with clinical symptoms and inflammatory parameters of *** During severe GVHD,the dielectric relaxation strength markedly increased and expression of band3 *** dielectric relaxation strength normalized with the improvement of *** vitro analysis confirmed that the increase of relaxation strength was associated with severe erythrocyte aggregates,but not with decreased expression of *** Severe erythrocyte aggregates observed in GVHD may cause coagulation abnormalities and circulatory failure,which,together with the irreversible erythrocyte dysfunction we recently reported,could lead to organ failure.

关键词： Graft-versus-host disease Dielectric relaxation Erythrocyte Stem cell transplantation coagulation

Anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts from Moroccan thyme varieties

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Asian Pacific Journal of Tropical Biomedicine 2015年第8期5卷 622-629页

作者： Tarik Khouya Mhamed Ramchoun Abdelbassat Hmidani Souliman Amrani Hicham Harnafi Mohamed Benlyas Younes Filali Zegzouti Chakib Alem Department of Biology Faculty of Sciences and Techniques University Moulay Ismail Laboratory of Biochemistry Department of Biology Faculty of Sciences University Mohamed First

Objective: To evaluate the anti-inflammatory, anticoagulant and antioxidant effects of aqueous extracts of thyme varieties from ***: The aqueous extracts of tree medicinal plants [Thymus atlanticus(T. atlanticus), Thymus satureioides and Thymus zygis(T. zygis)] were screened for their antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl radical-scavenging, ferric reducing antioxidant power assay, radical scavenging activity method, the inhibition of 2,2'-azobis(2-amidinopropane) dihydrochloride that induces oxidative erythrocyte hemolysis and thiobarbituric acid reactive substances assay. The anti-inflammatory activity of aqueous extracts was evaluated in vivo using croton oil-induced ear edema and carrageenan-induced paw edema in mice and rats, respectively. This extracts were evaluated in vitro for their anticoagulant activity at the different concentrations by partial thromboplastin time and prothrombin time activated. Results: All thyme varieties were found to possess considerable antioxidant activity and potent anti-inflammatory activity in the croton oil-induced edema. Administration of aqueous extracts of two varieties(50 mg/kg)(T. zygis and T. atlanticus) reduced significantly the carrageenaninduced paw edema similar to non-steroidal anti-inflammatory drug(indomethacin, 10 mg/kg). In partial thromboplastin time and prothrombin time tests, T. atlanticus and T. zygis extracts showed the strongest anticoagulant activity. In contrast, Thymus satureioides did not show the anticoagulant activity in these tests. Conclusions: All aqueous extracts possess considerable antioxidant activity and are rich in total polyphenol and flavonoid but they act differently in the process of inflammatory and coagulation studied. This study shows great variability of biological activities in thyme varieties.

关键词： Anti-inflammatory coagulation Antioxidant Thyme Polyphenol Rat

Application of Fe(Ⅵ)in abating contaminants in water:State of art and knowledge gaps

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Frontiers of Environmental Science & Engineering 2021年第5期15卷 7-27页

作者： Shuchang Wang Binbin Shao Junlian Qiao Xiaohong Guan State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai200092China International Joint Research Center for Sustainable Urban Water System Tongji UniversityShanghai200092China

The past two decades have witnessed the rapid development and wide application of Fe(Ⅵ)in the field of water de-contamination because of its environmentally benign ***(Ⅵ)has been mainly applied as a highly efficient oxidant/disinfectant for the selective elimination of *** in situ generated iron(III)(hydr)oxides with the function of adsorption/coagulation can further increase the removal of contaminants by Fe(Ⅵ)in some *** of the limitations of Fe(Ⅵ)per se,various modified methods have been developed to improve the performance of Fe(Ⅵ)oxidation *** on the published literature,this paper summarized the current views on the intrinsic properties of Fe(Ⅵ)with the emphasis on the self-decay mechanism of Fe(Ⅵ).The applications of Fe(Ⅵ)as a sole oxidant for decomposing organic contaminants rich in electron-donating moieties,as a bi-functional reagent(both oxidant and coagulant)for eliminating some special contaminants,and as a disinfectant for inactivating microorganisms were systematically ***,the difficulties in synthesizing and preserving Fe(Ⅵ),which limits the large-scale application of Fe(Ⅵ),and the potential formation of toxic byproducts during Fe(Ⅵ)application were *** paper also systematically reviewed the important nodes in developing methods to improve the performance of Fe(Ⅵ)as oxidant or disinfectant in the past two decades,and proposed the future research needs for the development of Fe(Ⅵ)technologies.

关键词： Ferrate Oxidation Disinfection coagulation Enhancement

A CLINICAL STUDY ON TREATMENT OF VASCULAR COMPLICATIONS OF DIABETES WITH THE SUGAR-REDUCING AND PULSE-INVIGORATING CAPSULE

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Journal of Traditional Chinese Medicine 1994年第1期14卷 3-9页

作者：林兰张鸿恩高齐健马践 Guang'anmen Hospital China Academy of Traditional Chinese Medicine Beijing 100053

The capsule is effective in replenishing qi, nourishing yin, activating blood, and resolving stasis. It can correct abnormalities in blood rheology, improve fat metabolism, enhance func-tioning of the islets of Langerhans, lower blood sugar, and alleviate clinical symptoms. Effi-cacious also against the chief vascular complications of diabetes, it helps in abating myocardial anoxia, improving left heart function, stimulating blood circulation to the brain, resisting coagulation and resolving thrombosis, also dilating the arteries of the legs. It is of some benefit in early diabetic retinopathy and renal diseases.

关键词： stasis Langerhans activating metabolism capsule rheology stimulating coagulation resolving arteries

氩离子凝固术与单纯药物治疗疣状胃炎疗效比较的荟萃分析

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临床军医杂志 2010年第5期38卷 737-739页

作者：张林侯艳红吴凯翟俊山王艳梅李楠解放军第309医院消化内科北京100091

目的比较氩离子凝固术配合药物治疗与单纯药物治疗对疣状胃炎的疗效差异,为临床选择治疗方式提供依据.方法通过计算机检索Pubmed、Medline及CBM数据库,搜集1988-2008年的相关文献,采取meta分析法对其中筛出的14篇符合要求的文献进行... 详细信息

目的比较氩离子凝固术配合药物治疗与单纯药物治疗对疣状胃炎的疗效差异,为临床选择治疗方式提供依据.方法通过计算机检索Pubmed、Medline及CBM数据库,搜集1988-2008年的相关文献,采取meta分析法对其中筛出的14篇符合要求的文献进行综合定量分析.结果氩离子凝固术治愈率为91.3%,单纯药物治疗的治愈率为19.2%.两种疗法加权合并率差均值为0.348(95%CI=0.243～0.464),对各项研究结果做齐性检验差异无统计学意义(P>0.05).结论氩离子凝固术治疗的治愈率显著高于单纯药物治疗.

关键词：氩离子凝固术药物治疗疣状胃炎疗效比较荟萃分析 drug treatment argon plasma coagulation 治愈率统计学意义计算机检索治疗方式文献临床选择疗效差异两种疗法结果检验差异定量分析 meta分析 Medline

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人凝血因子Ⅷ提取工艺优化研究

江西医药 2014年第2期49卷 107-109页

作者：邓志华何淑琴梁小明张丽铃黄璠江西博雅生物制药股份有限公司抚州344000

目的优化血浆中人凝血因子Ⅷ提取工艺条件。方法以人血浆冷沉淀为原料,人凝血因子Ⅷ的比活性回收率作为评价指标,采用单因素试验,对铝胶的加量,铝胶吸附时的pH值、酸沉淀时的pH值等进行研究,优选提取工艺。结果加入冷沉淀重量12%的铝胶... 详细信息

目的优化血浆中人凝血因子Ⅷ提取工艺条件。方法以人血浆冷沉淀为原料,人凝血因子Ⅷ的比活性回收率作为评价指标,采用单因素试验,对铝胶的加量,铝胶吸附时的pH值、酸沉淀时的pH值等进行研究,优选提取工艺。结果加入冷沉淀重量12%的铝胶,并将pH值调节至7.1进行吸附,上清液中人凝血因子Ⅷ比活性可达9.50IU/mg,酸沉淀时将pH值调节至6.3,离心上清夜中人凝血因子Ⅷ比活性为11.50 IU/mg。经过以上两步处理,可将人凝血因子Ⅷ比活性提高近2倍。结论人凝血因子Ⅷ提取工艺优化研究工艺合理、可行,能有效达到纯化提取人凝血因子Ⅷ的效果。

关键词：人凝血因子Ⅷ 铝胶吸附酸沉淀 Human coagulation factorⅧ

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凝血因子ⅩⅢ在病毒性肝炎患者血浆中的变化

中华传染病杂志 1987年第3期5卷 149-151页

作者：孙家强吴瑞庭张文化盛蓝明赵清海张天仁上海市传染病医院卫生部上海生物制品研究所

本文采用了兔抗人因子ⅩⅢ亚基(ⅩⅢ-a)和兔抗人因子ⅩⅢb亚基(ⅩⅢ-b)抗血清借电免疫扩散法测定了21名正常人及103例瞒毒性肝炎患者血浆因子ⅩⅢ亚基水平,结果发现血浆因子ⅩⅢa亚基抗原(ⅩⅢ-a:Ag)及b亚基抗原(ⅩⅢ-b:Ag)在各组肝炎... 详细信息

本文采用了兔抗人因子ⅩⅢ亚基(ⅩⅢ-a)和兔抗人因子ⅩⅢb亚基(ⅩⅢ-b)抗血清借电免疫扩散法测定了21名正常人及103例瞒毒性肝炎患者血浆因子ⅩⅢ亚基水平,结果发现血浆因子ⅩⅢa亚基抗原(ⅩⅢ-a:Ag)及b亚基抗原(ⅩⅢ-b:Ag)在各组肝炎患者血浆中均有显著下降.其中7例死亡者中有2例肝硬化ⅩⅢ-a:Ag和ⅩⅢ-b:Ag与正常组比较分别为29.8%和44.7%,5例重型肝炎为33.4%和68%,并伴有凝血酶原时间延长和不同程度的出血现象.这些结果表明了ⅩⅢ-a:Ag和ⅩⅢ-b:Ag值的测定对诊断和估计肝病的严重程度以及了解凝血系统的状态具有实用价值.

关键词：凝血因子ⅩⅢ 病毒性肝炎患者血浆 coagulation FACTOR 亚基 coagulation factor 凝血酶原时间延长 viral hepatitis 兔抗人免疫扩散法凝血系统抗原程度测定正常人死亡者抗血清肝硬化状态

INTEGRAL COLLISION KERNEL FOR THE GROWTH OF AEROSOL PARTICLES

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China Particuology 2005年第4期3卷 229-232页

作者： Hongyong Xie Center for Nanomatenals and Science Dalian University of Technology Dalian 116012 P. R. China

Integral collision kernel is elucidated using experimental results for titania, silica and alumina nanoparticles synthesized by FCVD process, and titania submicron particles synthesized in a tube fumace reactor. The integral collision kernel was obtained from a particle number balance equation by the integration of collision rates from the kinetic theory of dilute gases for the free-molecule regime, from the Smoluchowski theory for the continuum regime, and by a semi-empirical interpolation for the transition regime between the two limiting regimes. Comparisons have been made on particle size and the integral collision kernel, showing that the predicted integral collision kernel agreed well with the experimental results in Knudsen number range from about 1.5 to 20.

关键词： coagulation integral collision kemel nano and submicron particles aerosol process

Haemostatic system in inflammatory bowel diseases:New players in gut inflammation

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World Journal of Gastroenterology 2011年第5期17卷 594-608页

作者： Franco Scaldaferri Stefano Lancellotti Marco Pizzoferrato Raimondo De Cristofaro Department of Inter nal Medicine and Medical Specialties Gastroenterology Divi sionCatholic University of Rome00168 RomeItaly Department of Internal Medicine and Medical Specialties Haemostasis Research CenterCatholic University of Rome00168 RomeItaly

Inflammation and coagulation constantly influence each other and are constantly in *** evidence supports this statement in acute inflammatory diseases,such as sepsis,but it also seems to be very important in chronic inflammatory settings,such as inflammatory bowel disease(IBD).Patients with Crohn's disease and ulcerative colitis have an increased risk of thromboembolic events,and several abnormalities concerning coagulation components occur in the endothelial cells of intestinal vessels,where most severe inflammatory abnormalities *** aims of this review are to update and classify the type of coagulation system abnormalities in IBD,and analyze the strict and delicate balance between coagulation and inflammation at the mucosal *** studies on possible therapeutic applications arising from investigations on coagulation abnormalities associated with IBD pathogenesis will also be briefly presented and critically reviewed.

关键词： Activated protein C coagulation Crohn'sdisease Inflammation Inflammatory bowel disease Platelets Ulcerative colitis