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Routine Hemostasis and Hemogram Parameters： Valuable Assessments for coagulation disorder and Chemotherapy in Cancer Patients

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Chinese Medical Journal 2016年第15期129卷 1772-1777页

作者： Ying-Wei Zhu Tong-Bao Feng Xian-Ju Zhou Xue-Li Hu Jie Ding Wen-Yu Zhu Dan-Ping Qian Yi-Wu Sun Department of Oncology Changzhou Second People's Hospital The Affiliated Hospital of Nanjing Medical University Changzhou Jiangsu 213164 China Oncology Institute Changzhou Second People's Hospital The Affiliated Hospital of Nanjing Medical University Changzhou Jiangsu 213164 China Neurologic Disease Research Laboratory Changzhou Second People's Hospital The Affiliated Hospital of Nanjing Medical University Changzhou Jiangsu 213164 China Department of Hematology Changzhou Second People's Hospital The Affiliated Hospital of Nanjing Medical University Changzhou Jiangsu 213164 China

Background： The clotting system abnormalities are the common complication in cancer patients. The aim of this retrospective study was to evaluate the coagulation state, clinical features, and treatment in cancer patients by routine tests. Methods： A total of 2328 patients with different types of cancer were classified as the positive group （n = 1419, including 53 patients with thrombosis） and the negative group （n = 909） based on D-dimer （DD） value. Of the 2328 cases, 354 were admitted for chemotherapy. Hemostasis test and complete blood count （CBC） were perfbrmed during treatment or following-up. Results： This study showed that the hypercoagulable state was affected not only by clinical staging （P 〈 0,0001） but also by metastasis site （P 〈 0.0001 for bone vs. lung）. Compared to negative DD group, the higher fibrinogen level, the extended activated partial thromboplastin time, and prothrombin time interacted markedly with disease clinical stage （P 〈 0.05） in the positive group. Between positive DD groups with and without thrombus, the significantly statistic difference in white blood cell （WBC） and DD （P 〈 0.05） rather than in red blood cell （RBC） and platelet count was observed. However, the higher DD level was not correlated with WBC, RBC, and platelet count in the positive DD group. Furthermore, the hypercoagulable plasma profile in cancer patients was moderated 2-3 weeks alter chemotherapy （P 〈 0.05 for first six cycles）. Conclusions： The routine hemostatic parameters and CBC are valuable to assessment for thrombosis and chemotherapy even for disease prognosis.

关键词： Cancer Chemotherapy coagulation disorder Thrombosis

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Therapeutic effect of traditional Chinese medicine on coagulation disorder and accompanying intractable jaundice in hepatitis B virus-related liver cirrhosis patients

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World Journal of Gastroenterology 2008年第39期14卷 6060-6064页

作者： Yang-Mei Li Hong-Zhi Yang Wei-Bing Guan Qian-Shan Ke Min Dai He-Ping Xie Shi-Jun Zhang Departmentof TCM The Third Affiliated Hospital of Sun Yat-Sen University 600# Tianhe Road Guangzhou 510630 Guangdong Province China Department of TCM The First Affiliated Hospital of Sun Yat-Sen University 58# Zhongshan Er Road Guangzhou 510080 Guangdong Province China

AIM： TO observe the therapeutic effects of new traditional Chinese medicine （TClVl） therapy on coagulation disorder and accompanying intractable jaundice in HBV-related liver cirrhosis patients. METHODS： Using stratified random sampling according to fibrinogen （Fib） levels, 145 liver cirrhosis patients due to hepatitis B complicated by coagulation disorder were treated. Of them, 70 in research group were treated with TCM by ＂nourishing yin, cooling blood and invigorating blood circulation＂ and Western medicine, 75 in control group were treated with conventional Western medicine. The indexes of liver function, coagulation function and bleeding events were observed and compared. RESULTS： The prothrombin time （PT） was shorter and the fibrinogen （Fib） level was higher in the research group than in the control group （Fib = 1.6-2.0 g/L, 1.1-1.5 g/L, and ≤ 1.0 g/L）. The total bilirubin （TBIL） level was significantly lower in the research group than in the control group, except for the subgroup of FIB ≤ 1.0 g/L. CONCLUSION： TCM therapy can improve coagulation fuction and decrease TBIL.

关键词： Combination of traditional Chinese and Western medicine Liver cirrhosis coagulation disorder Nourishing yin Cooling blood and invigorating blood circulation

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A cross-sectional study of complementary and alternative medicine use in patients with coagulation disorders in Southern Iran

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Journal of Integrative Medicine 2017年第5期15卷 359-364页

作者： Mohammadreza Bordbar Mehdi Pasalar Rezvan Aresehiri Sezaneh Haghpanah Soheila Zareifar Fatemeh Amirmoezi Hematology Research Center Shiraz University of Medical SciencesShiraz ***Iran Research Center for Traditional Persian Medicine and History of Medicine Shiraz University of Medical SciencesShiraz ***Iran

OBJECTIVE：Complementary and alternative medicine（CAM）use has an increasing trend around the *** the wild application of CAM in patients with coagulation disorders,its efficacy is still questioned by many *** aim of this study was to determine the frequency and types of CAM usage,and the factors affecting CAM use among patients with bleeding ***：This cross-sectional study investigated the usage of CAM with a standard validated questionnaire in coagulopathic patients who were referred to Dastgheib Hospital,an educational therapeutic center affiliated to the Shiraz University of Medical Sciences in Shiraz,Southern ***：Between December 2015 and May 2016,75 patients were included in this *** hemophilia A and rare bleeding disorders were the most frequent among our ***,nearly half of the studied population（49.3%）used at least one CAM product or *** most common products were multivitamin（29.3%）,followed by folic acid（21.3%）and chamomile（12%）.32%of the patients resorted to faith *** main reasons of using CAM were reported to be increased general health,correction of anemia and thrombocytopenia and control of bleeding ***：CAM is being used frequently in patients with coagulation disorders like many other chronic illnesses all around the *** to emerging concern regarding the safety and possible interaction with the conventional medicine,it is necessary to develop basic data about the hematologic effects of these methods in order to use them more safely.

关键词： medicine, traditional complementary medicine alternative therapies coagulation disorder hemophilia Iran

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Molecular genetic analysis of coagulation factor Ⅺ severe deficiency in 8 Chinese pedigrees

Molecular genetic analysis of coagulation factor Ⅺ severe d...

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2019年浙江省检验医学学术大会

作者： KUANGYI SHU the Second Affiliated Hospital and Yuying Children Hospital of Wenzhou Medical University

Objective :This study was to better investigate the clinical, laboratory and genotypic spectrum of factor Ⅺ(F Ⅺ)deficiency in eight unrelated Chinese *** :Clinical and laboratory information were obtained from the subjects. The phenotype tests including prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT) and fibrinogen(FGN) were performed by automatic coagulation analyzer STA-evolution. F Ⅺ activity(F Ⅺ :C) was determined with a one-stage clotting assay based APTT. F Ⅺ antigen(F Ⅺ :Ag) was detected with an enzymelinked immunosorbent assay(ELISA). F11 genetic mutations of 8 pedigrees were identified by polymerase chain reaction(PCR) and sequencing. Genetic polymorphisms were excluded by directly sequencing in 105 healthy *** :All probands showed prolonged APTT(median 84.6 S,range 69.8-103.3 S),reduced F Ⅺ :C(median 3%,range 2-6%) and reduced F Ⅺ :Ag(median 2.3%, range 0.9-4.2%). In all subjects, the prothrombin time, thrombin time and Clauss fibrinogen were normal. Ten genetic mutations were identified in F11 of 8 families. Three novel mutations include a nonsense mutation(***532 Ter) in exon14, a missense mutation(***573 Asp) in exon15 and a 1-bp deletion(1491 delT) in exon12 causing a substitution of leucine465 by tryptophan and a terminal codon after seven amino acids: F11 NM3142 c.1491 delT(***465 Trp. fs*7). The result of ***573 Asp in Pymol showed that the substitution of glycine with aspartic acid may lead to a conformational and structural change in the catalytic domain of F Ⅺ. Of all the 8 probands, 2 had obvious bleeding ***:The identification and characterization of the novel mutations responsible for F Ⅺ deficiency widen the mutational spectrum of hereditary F Ⅺ deficiency.

关键词： factor Ⅺ factor Ⅺ deficiency bleeding genetic mutation coagulation disorder APTT

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