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Concomitant Chronic Lymphocytic Leukemia and Multiple Myeloma: Proof of Common clonal origin

The Chinese-German Journal of Clinical Oncology 2004年第2期3卷 81-84,125页

作者： Christoph Sucker Alwin Kramer Marion Moos Hartmut Goldsehmidt 德国海德堡大学内科学院 69115

We describe a patient with concomitant B-cell chronic lymphocytic leukemia (CLL) and multiple myeloma (MM). CLL- and MM-cell were separated by preparative flourescence-activated cell sorting (FACS). DNA sequence analysis of the complementarity-determinining region III (CDR III) of the immunoglobulin heavy chain genes showed identical gene rearrangements in the CLL- and the MM-cell population. Our findings prove a common clonal tumor origin of both B-cell diseases in this patient.

关键词： chronic lymphocytic leukemia multiple myeloma clonal origin immunoglobulin gene

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Combined hepatocellular and cholangiocarcinoma originating from the same clone:a pathomolecular evidence-based study

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Chinese Journal of Cancer 2016年第11期35卷 585-595页

作者： Qian Zhao Wen-Long Yu Xin-Yuan Lu Hui Dong Yi-Jin Gu Xia Sheng Wen-Ming Cong Meng-Chao Wu Department of Pathology Eastern Hepatobiliary Surgery HospitalSecond Military Medical University Department of Biliary Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical University Department of Hepatic Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical University

Background:Combined hepatocellular and cholangiocarcinoma(CHC) is a unique subtype of liver cancer comprising both hepatocellular carcinoma(HCC) and intrahepatic cholangiocarcinoma(ICC);however,its cellular origin remains *** purpose of this study was to investigate the clinicopathologic features and the clonal relationship between HCC and ICC in 34 patients with ***:The clinicopathologic features and prognosis of the 34 CHC patients were compared with those of 29 patients with separated HCC and ICC(5HC).Loss of heterozygosity(LOH) at 10 highly polymorphic microsatellite markers was detected in 16 CHC and 10 SHC tissues for determination of the clonal origin of *** of hepatocyte markers[hepatocyte paraffin 1(Hep Par 1) and glypican 3(GPC3)]and cholangiocyte markers[cytokeratin(CK)7 and 19]in tumor tissues was examined by immuno histochemical ***:In the 16 CHC specimens,the difference in LOH patterns between HCC and ICC was less than 30%,suggesting the same clonal origin of HCC and *** with this finding,immunohistochemical analysis revealed that hepatocyte markers(Hep Par 1 and GPC3) and cholangiocyte markers(CK7 and CK19) were simultaneously expressed in both the HCC and ICC components in 52.9%of CHC specimens,suggesting that the two components shared a similar phenotype with hepatic progenitor cells(HPCs).On the contrary,in all 10 SHC cases,the difference in LOH patterns between the HCC and ICC components was greater than 30%,suggesting different clonal origins of HCC and *** survival and disease-free survival were shorter for patients with CHC than for patients with SHC(P originate from the same clone,having the potential for dual-directional differentiation similar to *** tended to exhibit the biological behaviors of both HCC and ICC,which may enhance the infiltrative capacity of tumor cells,leading to poor clinical ou

关键词： Combined hepatocellular and cholangiocarcinoma Hepatocellular carcinoma Intrahepatic cholangiocellular carcinoma Loss of heterozygosity clonal origin Prognosis

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Small hepatocellular carcinoma: past, present and future

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CHINESE MEDICAL JOURNAL 1996年第1期109卷 24-24页

作者： Tang Zhaoyou LiverCancerInstitute ShanghaiMedicalUniversity Shanghai

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