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The risks, degree of malignancy and clinical progression of prostate cancer associated with the MDM2 T309G polymorphism： a meta-analysis

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Asian Journal of Andrology 2012年第5期14卷 726-731页

作者： Jie Yang Wen Gao Ning-Hong Song Wei Wang Jie-Xiu Zhang Pei Lu Li-Xin Hua Min Gu Department of Urology First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Cancer Biotherapy Centre First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

To determine the risk, malignant degree and clinical progression of prostate cancer （PCa） associated with mouse double-minute 2 protein （MDM2） T309G variants, a meta-analysis was performed on all eligible published studies. Odds ratios （ORs） with 95% confidence intervals （CIs） were estimated to assess these associations in seven studies that included 5151 cases and 1003 controls. In the overall analysis, the 309G allele was significantly associated with a decreased PCa risk （0R=0.85, 95% CI： 0.74-0.97）; this was also the case for the homozygous comparison （0R--0.72, 95% Ch 0.55-0.95） and the dominant genetic model （0R=0.79, 95% Ch 0.65-0.96）. The 309G allele was also found to be significantly associated with lower degrees of PCa malignancy （0R=0.85, 95% Ch 0.75-0.96） in the overall analysis, as well as in the heterozygous comparison （0R=0.79, 95% Ch 0.65-0.96）, homozygous comparison （0R=0.76, 95% Ch 0.58-0.98） and dominant genetic model （0R=0.81, 95% CI： 0.68-0.96）. Furthermore, grouping analysis showed that the 309G allele in Caucasians was significantly correlated with a decreased PCa risk （0R=0.77, 95% Ch 0.61-0.96）; this was also the case in the homozygous comparison （0R=0.51, 95% Ch 0.31-0.86）. The grouping analysis also showed that the 309G variant in Caucasians was significantly associated with a lower degree of PCa malignancy in all of the genetic models. In addition, we found that the 309G variant in Caucasians was significantly associated with a slower PCa clinical progression in all of the genetic models. In summary, our meta-analysis showed that the MDM2 309G variant was significantly associated with a decreased PCa risk, lower malignant degree and slower clinical progression in Caucasians, but there was no obvious association in the Asian population.

关键词： clinical progression malignant degree MDM2 meta-analysis polymorphism prostate cancer risk

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Correlation between molecular biomarkers and risk factors for the clinical progression of benign prostatic hyperplasia using tissue microarray immunostaining

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Chinese Medical Journal 2014年第23期127卷 4031-4035页

作者： Ma Ding Yang Bing Zhou Zhe Pan Dongliang Zhang Xianghua Department of Urology Peking University Shougang Hospital Beijing 100144 China

Background The pathogenesis of benign prostatic hyperplasia （BPH） has been widely studied,and several biomarkers are known to play roles in its *** study aimed to investigate the possible role of cysteine-rich protein 61 （CYR61）,vascular endothelial growth factor （VEGF）,androgen receptor （AR）,interleukin-6 （IL-6）,cytochrome c,caspase-3,and proliferating cell nuclear antigen （PCNA） in the clinical progression of *** Tissue specimens from 96 BPH cases who underwent transurethral resection of the prostate were processed and transferred to tissue *** age,prostate volume,serum prostate-specific antigen （PSA） level,and International Prostate Symptom Score （IPSS） of all BPH cases were collected before *** expression of CYR61,VEGF,AR,IL-6,cytochrome c,caspase-3,and PCNA was examined by immunostaining in the BPH specimens,and any possible correlation between the different biomarkers and risk factors for BPH clinical progression was *** The expression of CYR61,VEGF,AR,IL-6,cytochrome c,caspase-3,and PCNA in the BPH cases was 68.8％（66/96）,77.1％（74/96）,43.8％（42/96）,31.3％（30/96）,35.4％（34/96）,56.3％（54/96）,and 29.2％（28/96）,*** expression of both CYR61 and VEGF was positively correlated with patient age,prostate volume,and serum PSA level （P ＜0.05）.Furthermore,cytochrome c and caspase-3 expression were inversely related to prostate volume （P ＜0.05）,and AR expression was positively related to serum PSA level （P ＜0.05）.Conclusion CYR61 and VEGF expression might serve as biomarkers for predicting the clinical progression of BPH due to effects on stromal cell proliferation and angiogenesis.

关键词： biomarkers risk factors benign prostatic hyperplasia clinical progression tissue microarray

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Diagnostic value of serum human epididymis protein 4 in esophageal squamous cell carcinoma

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World Journal of Gastrointestinal Oncology 2020年第10期12卷 1167-1176页

作者： Shi-Yuan Liu Muhammad Ahsan Bilal Jian-Hong Zhu Shao-Min Li Department of Thoracic Surgery Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Dermatology and Venereology Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of clinical Laboratory Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina

BACKGROUND Numerous studies have demonstrated that human epididymis protein 4(HE4)is overexpressed in various malignant tissues including ovarian,endometrial,lung,breast,pancreatic,and gastric ***,no study has examined the diagnostic impact of HE4 in patient with esophageal squamous cell carcinoma(ESCC)until *** To analyze the value of four serum tumor markers for the diagnosis of ESCC,and examine the associations of serum levels of HE4 with ESCC patients’clinicopathological *** The case group consisted of 80 ESCC patients,which were compared to a control group of 56 patients with benign esophageal *** levels of HE4,carcinoma embryonic antigen(CEA),alpha fetal protein,and carbohydrate antigen 19-9(CA19-9)were detected by *** associations of serum HE4 levels with ESCC patients’clinicopathological characteristics such as gender,tumor location,and pathological stage were also examined after *** The result of ELISA showed that serum HE4 level was significantly higher in the patients with ESCC than in the controls,and the staining intensity was inversely correlated with the pathological T and N *** HE4 levels had a sensitivity of 66.2%and specificity of 78.6%when the cutoff value was set at 3.9 ng/***,the combined HE4 and CA19-9 increased the sensitivity to 83.33%,and interestingly,the combination of HE4 with CEA led to the most powerful sensitivity of 87.5%.Furthermore,A positive correlation was observed between HE4 serum levels and pathological T and N stages(P=0.0002 and 0.0017,respectively),but there was no correlation between HE4 serum levels and ESCC patient gender(P=0.4395)or tumor location(P=0.6777).CONCLUSION The results of this study suggest that detection of serum HE4 levels may be useful in auxiliary diagnosis and evaluation of the progression of ESCC.

关键词： Human epididymis protein 4 Esophageal squamous cell carcinoma Diagnostic value Histological stage Clinicopathological characteristics clinical progression

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Periprostatic fat thickness measured on MRI correlates with lower urinary tract symptoms,erectile function,and benign prostatic hyperplasia progression

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Asian Journal of Andrology 2021年第1期23卷 80-84页

作者： Bo Zhang Xiang Chen Yu-Hang Liu Yu Gan Pei-Hua Liu Zhi Chen Wei-Ping Xia Guo-Yu Dai Feng Ru Ze-Xiang Jiang Yao He Department of Urology Xiangya HospitalCentral South UniversityChangsha 410008China

This study investigated the correlation between periprostatic fat thickness(PPFT)measured on magnetic resonance imaging and lower urinary tract symptoms,erectile function,and benign prostatic hyperplasia(BPH)progression.A total of 286 treatment-naive men diagnosed with BPH in our department between March 2017 and February 2019 were *** were divided into two groups according to the median value of PPFT:high(PPFT>4.35 mm)PPFT group and low(PPFT<4.35 mm)PPFT *** the initial evaluation,all patients received a combination drug treatment of tamsulosin and finasteride for 12 *** the 286 enrolled patients,244 completed the drug treatment *** with high PPFT had larger prostate volume(PV;P=0.013),higher International Prostate Symptom Score(IPSS;P-0.008),and lower five-item version of the International Index of Erectile Function(IIEF-5)score(P=0.002)than those with low *** high and low PPFT groups showed significant improvements in PV,maximum flow rate,IPSS,and quality of life score and a decrease of IIEF-5 score after the combination drug *** decrease of IIEF-5 score was more obvious in the high PPFT group than that in the low PPFT *** addition,more patients in the high PPFT group underwent prostate surgery than those in the low PPFT ***,Pearson’s correlation coefficient analysis indicated that PPFT was positively correlated with age,PV,and IPSS and negatively correlated with IIEF-5 score;however,body mass index was only negatively correlated with IIEF-5 score.

关键词： benign prostatic hyperplasia clinical progression erectile function lower urinary tract symptoms periprostatic fat thickness

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