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clinical features and the traditional Chinese medicine therapeutic characteristics of 293 COVID-19 inpatient cases

Frontiers of Medicine 2020年第6期14卷 760-775页

作者： Zixin Shu Yana Zhou Kai Chang Jifen Liu Xiaojun Min Qing Zhang Jing Sun Yajuan Xiong Qunsheng Zou Qiguang Zheng Jinghui Ji Josiah Poon Baoyan Liu Xuezhong Zhou Xiaodong Li Institute of Medical Intelligence School of Computer and Information TechnologyBeijing Jiaotong UniversityBeijing 100044China Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan 430061China Institute of Liver Diseases Hubei Provincial Academy of Traditional Chinese MedicineWuhan 430061China School of Computer Science The University of SydneySydneyNew 2006Australia Analytic and clinical Cooperative Laboratory for Integrative Medicine USYD&CUHKSydneyNSW 2006Australia China Academy of Chinese Medical Sciences Beijing 100700China

Coronavirus disease 2019 (COVID-19) is now pandemic worldwide and has heavily overloaded hospitals in Wuhan City, China during the time between late January and February. We reported the clinical features and therapeutic characteristics of moderate COVID-19 cases in Wuhan that were treated via the integration of traditional Chinese medicine (TCM) and Western medicine. We collected electronic medical record (EMR) data, which included the full clinical profiles of patients, from a designated TCM hospital in Wuhan. The structured data of symptoms and drugs from admission notes were obtained through an information extraction process. Other key clinical entities were also confirmed and normalized to obtain information on the diagnosis, clinical treatments, laboratory tests, and outcomes of the patients. A total of 293 COVID-19 inpatient cases, including 207 moderate and 86 (29.3%) severe cases, were included in our research. Among these cases, 238 were discharged, 31 were transferred, and 24 (all severe cases) died in the hospital. Our COVID-19 cases involved elderly patients with advanced ages (57 years on average) and high comorbidity rates (61%). Our results reconfirmed several well-recognized risk factors, such as age, gender (male), and comorbidities, as well as provided novel laboratory indications (e.g., cholesterol) and TCM-specific phenotype markers (e.g., dull tongue) that were relevant to COVID-19 infections and prognosis. In addition to antiviral/antibiotics and standard supportive therapies, TCM herbal prescriptions incorporating 290 distinct herbs were used in 273 (93%) cases. The cases that received TCM treatment had lower death rates than those that did not receive TCM treatment (17/273= 6.2% vs. 7/20= 35%, P = 0.0004 for all cases;17/77= 22% vs. 7/9= 77.7%, P = 0.002 for severe cases). The TCM herbal prescriptions used for the treatment of COVID-19 infections mainly consisted of Pericarpium Citri Reticulatae, Radix Scutellariae, Rhizoma Pinellia, and the

关键词： COVID-19 traditional Chinese medicine clinical features

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clinical features and treatment options for mitral regurgitation in elderly inpatients

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Journal of Geriatric Cardiology 2018年第6期15卷 428-433页

作者： Rui-Qi ZHUGE Xiao-Pei HOU Xi-Ling QI Yong-Jian WU Ming-Zi ZHANG Department of Cardiology Fuwai Hospital National Center for Cardiovascular Disease Peking Union Medical College Chinese Academy of Medical Sciences Beijing China Department of Plastic Surgery Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China

Objective To summarize clinical characteristics and treatment strategy of Chinese elderly mitral regurgitation （MR） inpatients under the current guidelines, and to identify factors related to treatment options in them. Methods A single center retrospective study was conducted in which patients hospitalized in Fuwai hospital from May ist of 2014 to April 30 of 2015 with moderate to severe MR assessed by transthoraeic echocardiography were enrolled consecutively （n = 1741）. Patients 〉 60 years old were grouped as elderly group （n = 680） and patients 〈 60 years were grouped as control group （n = 1061）. The elderly group was categorized into two subgroups based on surgical status. Results The mean age of the elderly group was 66.98 i 5.94 years. The most common reason of MR in elderly group was degenerative MR （41.18%）. Atherosclerotic risk factors such as hypertension, diabetes or hyperlipidaemia were more commonly observed in elderly group than the control group （45.44% vs. 25.17%, P 〈 0.001; 19.56% vs. 8.48%, P 〈 0.001; 35.29% vs. 19.51%, P 〈 0.001）. Elderly group had higher Enroscore Ⅱ score （5.54 ± 2.42 vs. 3.15 ± 1.66）, greater left ventricular end diastolic diameter （LVEDD）（57.72±12.3 vs. 57.33 ± 10.19 ram） and a lower surgery rate （54.71% vs. 63.91%）; P 〈 0.05. Age, left ventricular ejection fraction （LVEF）, regurgitation grade, Eu- roScore-Ⅱ high risk stratification and having diabetes were identified as factors associated with therapy decisions in elderly MR patients. Conclusions Valve surgery was denied in 45.29% of elderly MR inpatients. Older age, impaired LVEF, lower regurgitation grade, Euro- Score-Ⅱ high risk stratification, and having diabetes were factors most significantly associated with surgery denial among elderly Chinese inpatients with MR.

关键词： clinical features Elderly patients Mitral regurgitation Treatment

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clinical features of elderly patients with COVID-19 in Wuhan,China

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World Journal of clinical Cases 2022年第35期10卷 12890-12898页

作者： Shuo Wei Guang Chen Xiao-Chun Ouyang Yuan-Cheng Hong Yun-Hu Pan Department of Infectious Disease Shengli Clinical Medical College of Fujian Medical UniversityFujian Provincial HospitalFuzhou 350000Fujian ProvinceChina Department of Respiratory Medicine 907 Hospital of the Joint Logistics TeamNanping 353000Fujian ProvinceChina No.4 Infection Department Second Ward Wuhan Huoshenshan HospitalWuhan 430010Hubei ProvinceChina Department of Respiratory Medicine 908 Hospital of the Joint Logistics TeamNanchang 330038Jiangxi ProvinceChina Department of Respiratory Medicine 910 Hospital of the Joint Logistics TeamQuanzhou 362046Fujian ProvinceChina

BACKGROUND Elderly patients with coronavirus disease 2019(COVID-19)who have comorbidities,frailty or profound disabilities experience poor *** analyzed the clinical characteristics of elderly patients from Wuhan who had COVID-19 during the early stages of the *** To identify factors affecting the early mortality of elderly patients with *** The records of 234 patients who were 65-years-old or more and were hospitalized in Wuhan Huoshenshan Hospital from February 4 to March 4,2020 were *** patients had confirmed COVID-19 and the final date of follow-up was April 4,*** There were 163 cases of mild disease(69.66%),39 cases of severe disease(16.67%)and 32 cases of critical disease(13.68%).Twenty-nine patients died within 1 mo(12.40%),all of whom had critical *** patients and deceased patients had no significant differences in age or chronic ***,the most common symptoms were fever(65.4%),dry cough(57.3%),fatigue(47.4%)and shortness of breath(41%).The deceased patients had higher levels of multiple disease markers(C-reactive protein,D-dimer,lactate dehydrogenase,alanine amino transferase,aspartate aminotransferase,creatinine kinase and creatinine kinase-MB)and higher incidences of lymphocytopenia and *** This single-center study of elderly patients from Wuhan,China who were hospitalized with COVID-19 indicated that age and chronic diseases were not associated with ***,diabetes and cardiovascular disease were the most common comorbidities and the most common symptoms were fever,dry cough,fatigue and shortness of ***,increased levels of D-dimer and other markers indicative of damage to the heart,kidneys or liver were associated with an increased risk of death.

关键词： Elderly COVID-19 Chronic underlying diseases clinical features Supportive treatment

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clinical features of intracerebral hemorrhage in patients with colorectal cancer and its underlying pathogenesis

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 2180-2189页

作者： Xu-Hui Deng Jing Li Shi-Jian Chen Yi-Ju Xie Jian Zhang Geng-Yu Cen Yi-Ting Song Zhi-Jian Liang Department of Neurology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Neurology The Affiliated Yuebei People’s Hospital of Shantou University Medical CollegeShaoguan 512025Guangdong ProvinceChina Department of General Medicine The Affiliated Cancer Center of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND The diagnosis of both cancer and intracerebral hemorrhage(ICH)in the same patient is not uncommon,but the clinical features and pathogenesis of patients with colorectal cancer(CRC)and ICH are still not well *** To investigate the clinical features and underlying pathogenesis of ICH in patients with *** A retrospective review of CRC patients complicated with ICH from three centers between January 2014 and December 2020 was *** data such as laboratory examinations,imaging features,prognosis,and underlying pathogenesis were *** Of 16673 identified CRC patients,20(0.12%)suffered from *** were 13 males and 7 females,with an average age(mean±SD)of 68.45±10.66 *** patients(70%)had distant metastases and most patients(85%)showed an elevation of one or more cancer *** hemorrhagic lesions in 13 patients(65%)were in the intracerebral *** patients were completely dependent and 4 died within 30 days after *** hemorrhage(50%)and coagulopathy(50%)accounted for the majority of *** Patients with ICH and CRC often have clinical features with lobar hemorrhage,distant metastases and poor *** hemorrhage and coagulopathy are the main causes of ICH in patients with CRC.

关键词： Colorectal cancer Intracerebral hemorrhage clinical features Pathogenesis

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clinical features and prognostic factors of duodenal neuroendocrine tumours:A comparative study of ampullary and nonampullary regions

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 907-918页

作者： Sa Fang Yu-Peng Shi Lu Wang Shuang Han Yong-Quan Shi Department of Gastroenterology Honghui HospitalXi’an Jiaotong UniversityXi'an 710054Shanxi ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710032Shaanxi ProvinceChina Department of Gastroenterology Xijing Hospital Affiliated to Air Force Medical UniversityXi'an 710032Shaanxi ProvinceChina

BACKGROUND Duodenal neuroendocrine tumours(DNETs)are rare ***,the incidence of DNETs has been increasing in recent years,especially as an incidental finding during endoscopic ***,there is no consensus regarding the ideal treatment of *** there are few studies on the clinical features and survival analysis of *** To analyze the clinical characteristics and prognostic factors of patients with duodenal neuroendocrine *** The clinical data of DNETs diagnosed in the First Affiliated Hospital of Air Force Military Medical University from June 2011 to July 2022 were ***-docrine tumours located in the ampulla area of the duodenum were divided into the ampullary region group;neuroendocrine tumours in any part of the duo-denum outside the ampullary area were divided into the nonampullary region *** a retrospective study,the clinical characteristics of the two groups and risk factors affecting the survival of DNET patients were *** Twenty-nine DNET patients were *** male to female ratio was 1:1.9,and females comprised the *** ampullary region group accounted for 24.1%(7/29),while the nonampullary region group accounted for 75.9%(22/29).When diagnosed,the clinical symptoms of the ampullary region group were mainly abdominal pain(85.7%),while those of the nonampullary region groups were mainly abdominal distension(59.1%).There were differences in the composition of staging of tumours between the two groups(Fisher's exact probability method,P=0.001),with nonampullary stage II tumours(68.2%)being the main stage(P<0.05).After the diagnosis of DNETs,the survival rate of the ampullary region group was 14.3%(1/7),which was lower than that of 72.7%(16/22)in the nonampullary region group(Fisher's exact probability method,P=0.011).The survival time of the ampullary region group was shorter than that of the nonampullary region group(P<0.000).The median survival time of the ampullary

关键词： Duodenum Neuroendocrine Tumour Ampullary Nonampullary clinical features Prognostic

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clinical features of SARS-CoV-2-associated encephalitis and meningitis amid COVID-19 pandemic

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World Journal of clinical Cases 2021年第5期9卷 1058-1078页

作者： Liang Huo Kai-Li Xu Hua Wang Department of Pediatrics Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Pediatric Neurology Children’s Hospital Affiliated to Zhengzhou UniversityZhengzhou 450018Henan ProvinceChina Department of Pediatric Neurology Henan Children’s HospitalZhengzhou 450018Henan ProvinceChina Department of Pediatric Neurology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Since the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)epidemic,numerous studies have been published on SARS-CoV-2-related encephalitis/meningitis,but it has not been established if there are specific clinical characteristics of encephalitis/meningitis associated with SARS-CoV-2 *** To identify the specific clinical features of cases of encephalitis/meningitis associated with SARS-CoV-2 infection in the context of this virus infection pandemic and investigate their relationship with SARS-CoV-2 *** We searched PubMed,and included single case reports and case series with full text in English,reporting original data of coronavirus disease-19(COVID-19)patients with encephalitis/meningitis and a confirmed recent SARS-CoV-2 *** data were *** We identified 22 articles(18 single case reports and 4 case series)reporting on a total of 32 encephalitis/meningitis patients with confirmed SARS-CoV-2 ***-CoV-2 infection was confirmed through reverse transcriptase-polymerasechain-reaction(RT-PCR)in 96.88%of cases.A total of 22(68.75%)patients had symptoms of SARS-CoV-2 infection in about 1 wk(7.91 d)preceding the onset of neurologic *** most common neurological symptoms were consciousness disturbance(59.38%),seizure(21.88%),delirium(18.75%),and headache(18.75%).Four cases were confirmed by positive RT-PCR results in cerebrospinal fluid(CSF),one was confirmed by positive RT-PCR results in postoperative brain tissue,and one by the presence of SARS-CoV-2 antibodies in *** mainly damaged targets identified by neuroimaging included the temporal lobe(15.63%),white matter(12.5%),frontal lobe(9.38%),corpus callosum(9.38%),and cervical spinal cord(9.38%).Eighty percent of patients had electroencephalograms that showed a diffuse slow ***-eight(87.5%)patients were administered with specific *** majority(65.63%)of patients improved following systemic *** Enceph

关键词： COVID-19 SARS-CoV-2 Encephalitis Meningitis clinical features System review

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clinical features of upper gastrointestinal serrated lesions: An endoscopy database analysis of 98746 patients

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World Journal of Gastroenterology 2016年第45期22卷 10038-10044页

作者： Hai-long Cao Wen-xiao Dong Meng-que xu yu-jie Zhang Si-nan Wang Mei-yu Piao xiao-Cang Cao Bang-Mao Wang Department of Gastroenterology and Hepatology General Hospital Tianjin Medical University Tianjin Institute of Digestive Disease Department of Pathology General Hospital Tianjin Medical University

AIM To analyse the clinical features of patients with the serrated lesions in the upper gastrointestinal tract(UPGI) *** Patients who underwent routine esophagogastroduodenoscopy(EGD) at the Digestive Endoscopy Centre of General Hospital, Tianjin Medical University between january 2011 and December 2015 were consecutively recruited. Patients with UPGI serrated lesions were consecutively identified. The patients' demographics and histopathology were recorded. The colorectal findings for patients who underwent colonoscopy simultaneously or within six months were also extracted from the colonoscopy database. In addition, we analyseddifferences in colorectal neoplasia detection between the study patients and randomly selected patients matched for age and gender who did not exhibit serrated lesions and who also underwent colonoscopy in the same *** A total of 21 patients out of 98746 patients(0.02%) who underwent EGD were confirmed to have serrated lesions with predominantly crenated, sawtooth-like configurations. The mean age of the 21 patients was(55.3 ± 17.2) years, and 11 patients were male(52.4%). In terms of the locations of the serrated lesions, 17 were found in the stomach(including 3 in the cardia, 9 in the corpus and 5 in the antrum), 3 were found in the duodenum, and 1 was found in the esophagus. Serrated lesions were found in different mucosal lesions, with 14 lesions were detected in polyps(8 hyperplastic polyps and 6 serrated adenomas with low grade dysplasia), 3 detected in Ménétrier gastropathy, 3 detected in an area of inflammation or ulcer, and 1 detected in the intramucosal carcinoma of the duodenum. In addition, colonoscopy data were available for 18 patients, and a significantly higher colorectal adenoma detection rate was observed in the UPGI serrated lesions group than in the randomly selected age- and gender-matched group without serrated lesions who also underwent colonoscopy in the same period(38.9% vs 11.1%, OR = 5.091, 95%

关键词： clinical features Upper gastrointestinal tract Serrated lesions Colorectal adenoma Colorectal cancer

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clinical features of 162 fatal cases of COVID-19:a multi-center retrospective study

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Emergency and Critical Care Medicine 2022年第3期2卷 109-115页

作者： Xianlong Zhou Guoyong Ding Qing Fang Jun Guo Luyu Yang Ping Wang Shou-Zhi Fu Ang Li Jian Xia Jiangtao Yu Jianyou Xia Min Ma Zhuanzhuan Hu Lei Huang Ruining Liu Cheng Jiang Shaoping Li Mingxia Yu Xizhu Xu Yan Zhao Quan Hu Weijia Xing Zhigang Zhao Emergency Center Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina School of Public Health Shandong First Medical University and Shandong Academy of Medical SciencesTai’anShandongChina Emergency Department General Hospital of Central Theater Command of PLAWuhanHubeiChina Intensive Care Unit Huazhong University of Science and Technology Union Jiangbei HospitalWuhanHubeiChina Intensive Care Unit Wuhan Third HospitalWuhanHubeiChina Department of Urology General Hospital of Central Theater Command of PLAWuhanHubeiChina Department of clinical Laboratory Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina Hubei clinical Research Center for Emergency and Resuscitation Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina Intensive Care Unit The First People’s Hospital of Jiangxia DistrictWuhanHubeiChina

Background:The coronavirus disease 2019(COVID-19)has affected approximately 2 million individuals worldwide;however,data regarding fatal cases have been ***:To report the clinical features of 162 fatal cases of COVID-19 from 5 hospitals in Wuhan between December 30,2019 and March 12,***:The demographic data,signs and symptoms,clinical course,comorbidities,laboratory findings,computed tomographic(CT)scans,treatments,and complications of the patients with fatal cases were retrieved from electronic medical ***:The median patient age was 69.5(interquartile range:63.0–77.25)years,and 80%of the patients were over 61 years.A total of 112(69.1%)patients were ***(45.1%)was the most common comorbidity,while 59(36.4%)patients had no *** admission,131(81.9%)patients had severe or critical COVID-19,whereas 39(18.1%)patients with hypertension or chronic lung disease had moderate *** total,126(77.8%)patients received antiviral treatment,while 132(81.5%)patients received glucocorticoid treatment.A total of 116(71.6%)patients were admitted to the intensive care unit(ICU),and 137(85.1%)patients received mechanical *** patients received mechanical ventilation before ICU *** 93.2%of the patients developed respiratory failure or acute respiratory distress *** were no significant differences in the inhospital survival time among the hospitals(P=0.14).Conclusion:Young patients with moderate COVID-19 without comorbidity at admission could also develop fatal *** in-hospital survival time of the fatal cases was similar among the hospitals of different levels in Wuhan.

关键词： clinical features Coronavirus disease 2019 Fatal cases Survival time

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Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China

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Frontiers of Medicine 2023年第6期17卷 1030-1046页

作者： Dong Wei Yusang Xie Xuefei Liu Rong Chen Min Zhou Xinxin Zhang Jieming Qu IDepartment of Infectious Diseases Research Laboratory of Clinical VirologyRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Pulmonary and Critical Care Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Institute of Respiratory Diseases Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Key Laboratory of Emergency Prevention Diagnosis and Treatment of Respiratory InfectiousDiseasesShanghai 200025China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was reported at the end of 2019 as a worldwide health concern causing a pandemic of unusual viral pneumonia and many other organ damages,which was defined by the World Health Organization as coronavirus disease 2019(COVID-19).The pandemic is considered a significant threat to global public health till *** this review,we have summarized the lessons learnt during the emergence and spread of SARS-CoV-2,including its prototype and *** overall clinical features of variants of concern(VOC),heterogeneity in the clinical manifestations,radiology and pathology of COVID-19 patients are also discussed,along with advances in therapeutic agents.

关键词： coronavirus disease 2019 SARS-CoV-2 epidemiology clinical features

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clinical features of dementia with lewy bodies in 35 Chinese patients

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Translational Neurodegeneration 2014年第1期3卷 1-5页

作者： Ding Han Qiong Wang Zhongbao Gao Tong Chen Zhenfu Wang Department of Neurology South BuildingGeneral Hospital of Chinese PLABeijing 100853China

Objective:To investigate the clinical features of dementia with Lewy bodies(DLB)in a Chinese ***:Computer-based online searches through China Biology Medicine disc and China National Knowledge Infrastructure were performed to collect case reports of DLB published between 1980 and *** characteristics were ***:A total of 18 studies comprising 35 patients(26 males and 9 females)were *** mean age at onset was 67.2±9.8 *** was characterized by memory impairment and accounted for 58.8%of all cases,followed by parkinsonism(11.8%),visual hallucinations(8.8%),and compulsive personality disorder(2.9%).The other patients(17.6%)presented two of the three core features of DLB at *** disease progression,parkinsonism was reported in 100%of cases,followed by visual hallucinations(97.1%),psychiatric symptoms(85.7%),severe neuroleptic sensitivity(81.8%),fluctuating cognition(68.6%),repeated falls(40.0%),sleep disorders(22.9%),and transient loss of consciousness(17.1%).26 patients who were subjected to Mini-Mental State Examination scored≤24.10 patients presented relative preservation of hippocampus and medial temporal lobe structures on CT/MRI *** hypometabolism occurred in 2 of 3 patients who underwent SPECT/PET perfusion scan.12 patients showed an increasing of slow frequency activity on EEG,prominently in frontal and temporal ***:DLB often strikes elderly *** clinical core features are dementia,fluctuating cognition,recurrent visual hallucinations and spontaneous features of ***,neuroimaging and EEG examinations may improve the diagnostic accuracy and discriminate DLB from other dementias.

关键词： Dementia with Lewy bodies Secondary literature evaluation clinical features Neurodegenerative disease

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