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Effectiveness and Safety of Acupoint Application of Guan Xin Su He Pill (冠心苏合丸) for Patients with Chronic Stable Angina Pectoris: A Multi-Center, randomized controlled trial

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Chinese Journal of Integrative Medicine 2021年第11期27卷 838-845页

作者： LI De-hua XIE Jin REN Yu-lan ZHENG Hui LYU Jun-ling LENG Jun-yan ZHANG Ling-lin ZHANG Jie FAN Hai-long LIANG Fan-rong Department of Acupuncture and Moxibustion Hospital of Chengdu University of Traditional Chinese MedicineChengdu610075China Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu610075China

Objective To assess the clinical effectiveness of acupoint application(AP)of Guan Xin Su He Pill(冠心苏合丸,GXSHP)for patients with chronic stable angina pectoris(CSAP).Methods This study was carried out in 3 local hospitals in Chengdu,*** baseline evaluation,eligible patients were randomly assigned to the placebo application for acupoints(PAA)group or the herbal application for acupoints(HAA)*** in the HAA group underwent AP with herbal powder,which was mainly GXSHP,and patients in the PAA group underwent AP with sham *** each treatment session,unilateral acupoints including Neiguan(PC 6),Danzhong(RN 17),Xinshu(BL 15)and Jueyinshu(BL 14),were stimulated for both *** was performed 3 times a week with a 2-day interval for 4 *** primary outcome was the frequency of angina pectoris attacks per week,while the secondary outcomes included angina pain intensity measured by the Visual Analogue Scale(VAS),dose of rescue oral drugs(nitroglycerin),scores on the Seattle Angina Questionnaire(SAQ),Self-Rating Anxiety Scale scores(SAS)and Self-Rating Depression Scale scores(SDS).clinical outcomes were measured at week 0,4 and *** safety of AP of GXSHP treatment for CSAP were *** A total of 121 patients were *** characteristics were comparable across the 2 *** treatment,the angina attack numbers in the HAA group were significantly reduced from 11.00 to 4.81(Pclinical outcomes showed better improvement after treatment in the HAA group than in the PAA group in terms of oral administration of rescue drugs,SAS,SDS and SAQ scores(P<0.0

关键词： acupoint application chronic stable angina pectoris clinical efficacy randomized controlled trial

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