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Relationship between fever and early clinical diagnosis and treatment in mild COVID-2019 patients

Journal of Hainan Medical University 2020年第20期26卷 1-6页

作者： Chu-Fen Lin Xue-Bin Ling Yong-Neng Ji Shi-Bin Lin Qing-Wen Meng JingLin Tian-Fa Li Department of Health Management Physical Examination Haikou People'Hospital Haikou 570208China Department of Cardiovasology The First Affiliated HospitalHainan Medical College Haikou 570102China Department of pharmacy The First Affiliated HospitalHainan Medical College Haikou 570102China Department of Medical Ultrasonic The First Affiliated HospitalHainan Medical College Haikou 570102China

Objective:To investigate the relationship between clinical manifestations,blood testing,chest CT,treatment and fever of 457mild cases of ***:A tatal of 457cases of mild COVID-19 diagnosed in Wuhan Jianghan module Hospital from February 6,2020 to February 26,2020 were gathered,and the cases with/without fever were retrospectively analyzed in epidemiology,clinical manifestation,blood routing,hypersensitive C-reactive protein(hs-CRP),pathogens serological testing,chest CT and drugs ***:For 312 fever cases,the average age was(47.6±10.9)years old,male was 128 cases(41%),the mean peak fever was 38(36.8,38.6)℃,fever lasting was 2(0,3)days,131cases(28.7%)had Huanan seafood market exposure history,90 cases(28.8%)had closely contact with COVID-19 patients,20cases(6.4%)had hypertension history,10 cases(3.2%)had diabetes,5cases(1.6%)had coronary heart *** symptoms of fever group including dry cough of 260cases(83.3%),of 104cases(33.3%),blood sputum of 9cases(2.9%),chest tightness 20cases(19.6%),shortness of breath of 87cases(27.9%),weak of 105cases(33.7%),diarrhea of 43cases(13.8%),sleep disorders of 61cases(19.6%),among fever cases with sputum and shortness of breath more rather without fever,and two groups were statistically significantly difference(P<0.05).In fever group,WBC(109/L)[4.34(3.69,5.26)than 5.11(4.22,6.22),P<0.001],NEUT(109/L)[2.67(2.1,3.49)than 2.88(2.37,3.9),P<0.05],LYM(109/L)[0.9(0.8,1.1)than 1.36(1.03,1.85),P<0.001),PLT(109/L)/(106,188)134-189(132,224),P<0.001)were lower than normal group,while WBC<4.0×109/L[108(34.6%)than 24(16.6%),P<0.001)],LYM<1.0×109/L[189(60.6%)than 31(21.4%),P<0.001)],PLT<100×109/L[45(14.4%)than in 2(1.4%),P<0.001)and hs-CRP(mg/L)[14(6.83,32)than 3.4(0.96,10.75),P<0.001)were higher than normal group,and pathogens serological examination of 36cases shown influenzaⅠ/Ⅱvirus IgM antibody positive in 3cases(8.3%),respiratory syncytial virus IgM antibody positive in 2 cases(5.6%),mycoplasma pneumoniae IgM an

关键词： COVID-19 Mild Early onset clinical diagnosis and treatment Fever

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Research on the Causes and Preventive Measures of Pregnancy Complicated by Acute Abdomen

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Open Journal of Obstetrics and Gynecology 2025年第1期15卷 97-107页

作者： Feng Gao Changsha First Hospital Changsha China

Acute abdomen refers to a sudden onset of severe abdominal pain that may require urgent surgical intervention, while biliary system diseases encompass disorders affecting the gallbladder, bile ducts, and associated structures. Acute abdomen during pregnancy represents one of the most challenging critical conditions in obstetrics, with its morbidity and mortality rates consistently ranking among the leading causes of maternal death. In recent years, with population aging and an increasing proportion of advanced-age pregnancies, the incidence of pregnancy-associated acute abdomen has shown an upward trend. This study systematically analyzes the primary etiologies, clinical characteristics, and therapeutic strategies of acute abdomen during pregnancy while exploring the effectiveness of preventive measures. Research indicates that pregnancy-specific anatomical and physiological changes, environmental factors, and genetic background play crucial roles in disease occurrence. The establishment of a comprehensive prevention system, including pre-pregnancy assessment, gestational monitoring, and emergency response planning, can significantly reduce incidence rates. Multi-center clinical data analysis demonstrates that early identification of risk factors, standardized prenatal examinations, and establishment of rapid diagnosis and treatment channels are key to improving successful treatment rates. This study provides new insights and methodologies for reducing the incidence and mortality rates of pregnancy-associated acute abdomen, holding significant implications for improving maternal and fetal outcomes.

关键词： Pregnancy-Associated Acute Abdomen Etiology Prevention System clinical diagnosis and treatment Prognosis Evaluation

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Management of primary ciliary dyskinesia/Kartagener＇s syndrome in infertile male patients and current progress in defining the underlying genetic mechanism

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Asian Journal of Andrology 2014年第1期16卷 101-106页

作者： Yan-Wei Sha Lu Ding Ping Li Reproductive Medicine Center Maternal and Child Health Hospital of Xiamen Xiamen China

Kartagener＇s syndrome （KS） is an autosomal recessive genetic disease accounting for approximately 50% of the cases of primary ciliary dyskinesia （PCD）. As it is accompanied by many complications, PCD/KS severely affects the patient＇s quality of life. Therapeutic approaches for PCD/KS aim to enhance prevention, facilitate rapid definitive diagnosis, avoid misdiagnosis, maintain active treatment, control infection and postpone the development of lesions. In male patients, sperm flagella may show impairment in or complete absence of the ability to swing, which ultimately results in male infertility. Assisted reproductive technology will certainly benefit such patients. For PCD/KS patients with completely immotile sperm, intracytoplasmic sperm injection may be very important and even indispensable. Considering the number of PCD/KS susceptibility genes and mutations that are being identified, more extensive genetic screening is indispensable in patients with these diseases. Moreover, further studies into the potential molecular mechanisms of these diseases are required. In this review, we summarize the available information on various aspects of this disease in order to delineate the therapeutic objectives more clearly, and clarify the efficacy of assisted reproductive technology as a means of treatment for patients with PCD/KS-associated infertility.

关键词： assisted reproductive technology clinical diagnosis and treatment genetic mechanism Kartagener's syndrome malefertifity, primary ciliary dyskinesia

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Recent Advances in HIV-Associated Neurocognitive Disorders

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Journal of Biosciences and Medicines 2023年第9期11卷 150-157页

作者： Qianqian Tang Hao Wu Maogong Tang Jiangsu Provincial People’s Hospital Pukou Branch Nanjing China Infection Center of Beijing You’an Hospital Beijing China Huai’an Economic and Technological Development Zone Hospital Huai’an China

HIV-associated neurocognitive disorders (HAND) are chronic complications of HIV infection in the central nervous system. clinical presentations include asymptomatic neurocognitive impairment (ANI), mild neurocognitive impairment (MND), and HIV-associated dementia (HAD). In the era of combination antiretroviral therapy (cART), the prevalence of HAD has significantly decreased, but the rates of ANI and MND have increased, impairing patients’ daily functioning, medical adherence, employment, driving abilities, risk of HIV transmission, overall quality of life, and posing challenges to society, economy, families, and public health. This article reviews the latest research findings regarding the pathogenesis, clinical diagnosis and treatment, neuroimaging, and neuropsychological assessment of HAND, aiming to provide insights into the prevention and management of HAND.

关键词： HIV-Associated Neurocognitive Disorders (HAND) Pathogenesis clinical diagnosis and treatment Neuroimaging Neuropsychological Assessment

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