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Expression of TLR10 in B-cell subsets correlates with Primary Sj?gren's Syndrome progression

Expression of TLR10 in B-cell subsets correlates with Primar...

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第十四届全国免疫学学术大会

作者： Nannan Lai Yichao Qian Xi Jiang Honghua Sun Zhaofan Luo Bihui Huang Scientific Research Center The Seventh Affiliated Hospital of Sun Yat-sen University Department of Clinical Laboratory The Seventh Affiliated Hospital of Sun Yat-sen University Department of Transfusion The Seventh Affiliated Hospital of Sun Yat-sen University

Primary Sjogren’s Syndrome(pSS) is considered a B cell-mediated disease,yet the precise role of B cells in the pathogenesis is not fully ***10 is highly expressed in B cells,indicating that TLR10 probably plays a vital role in the progression of B cell-related ***,the biology of TLR10 in pSS is less ***,we detected the expression of TLR10 in peripheral B cell subsets from pSS patients and healthy controls(HCs) and further analyzed the correlations of TLR10 expression with disease *** observed that TLR10 expression in peripheral CD19B cells and CD19CD27lgDswitched memory B cells was significantly increased in the low activity pSS patients as compared with the HCs and high activity pSS ***10 expression in CD19B cells and switched memory B cells in pSS patients was significantly negatively correlated with anti-SSA antibody and BAFF ***,the TLR10 high-expressed pSS patients presented with decreased percentage of switched memory B cells and very low proportion of high-activity pSS patients,as compared with the TLR10 low-expressed pSS *** study concluded that TLR10 expression in CD19B cells and switched memory B is negatively correlated with pSS disease activity and TLR10 might suppress pSS progression via inhibiting B cell *** results should contribute to the diagnosis and treatment of pSS.

关键词： Toll like receptor 10 B cells Primary Sj?gren’s Syndrome class switch recombinant autoantibodies

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