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citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif

Journal of Molecular Cell Biology 2019年第11期11卷 1006-1017页

作者： Thi Hai Yen Tran Dae-Wook Yang Minchul Kim Da-Hye Lee Marta Gai Ferdinando Di Cunto Kwang-Wook Choi Dae-Sik Lim Department of Biological Sciences KAIST 291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Department of Molecular Biotechnology and Health Sciences University of Turin10126 TurinItaly

The inhibitory effect of large tumor suppressor kinase(LATS1/2)on the activity of the oncoprotein yes-associated protein(YAP)is crucial to maintain tissue *** studies have identified several new regulators of this ***,citron kinase(CIT)was listed as a potential binding candidate of Hippo-related components,suggesting a new connection between CIT and the Hippo *** from CITs role in cytokinesis,the molecular crosstalk between CIT and the Hippo pathway is largely ***,we demonstrate a role for CIT as a scaffold protein Unking LATS2 and *** importantly,CIT interacts with LATS2 to directly suppress LATS2 phosphorylation at the hydrophobic motif—targeted by MST1,leading to LATS2 inactivation and YAP *** studying their genetic interactions,we found that Sticky,the CIT homolog in Drosophila melanogaster,functions with Warts to control Drosophila eye ***,our study confirms citron kinase as a novel regulator of the Hippo pathway.

关键词： citron kinase LATS2-YAP interaction LATS2 inhibition sticky-warts Hippo pathway

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Hrs inhibits citron kinase-mediated HIV-1 budding via its FYVE domain

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Protein & Cell 2011年第6期2卷 470-476页

作者： Jiwei Ding Lishan Su Guangxia Gao Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Graduate University of Chinese Academy of Sciences Beijing 100039China The University of North Carolina Chapel HillNC 27599-7295USA

Hepatocyte growth factor-regulated tyrosine kinase substrate(Hrs)is a key component of the endosomal sorting complexes required for transport and has been demonstrated to play a regulatory role in endocytosis/exocytosis and the accumulation of internal vesicles in multivesicular *** kinase is a Ser/The kinase that we previously reported to enhance human immunodeficiency virus type 1(HIV-1)virion ***,the relationship between Hrs and citron kinase in HIV-1 production remains ***,we report that Hrs interacts with citron kinase via its FYVE *** of Hrs or the FYVE domain resulted in a significant decrease in HIV-1 virion *** of Hrs by RNA interference in HEK293T cells increased HIV-1 virion production and enhanced the activity of citron *** data suggest that Hrs inhibits HIV-1 production by inhibiting citron kinase-mediated exocytosis.

关键词： citron kinase Hrs HIV-1 budding

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