检索结果-南通市图书馆

Changes in Plasma Angiotensin II and circadian rhythm of blood pressure in Hypertensive Patients with Sleep Apnea Syndrome Before and After Treatment

引用

Chinese Medical Sciences Journal 2011年第1期26卷 9-13页

作者： Hai-ling Wang Yu Wang Ying Zhang Yun-dai Chen Xin-chun Wang Zhi-xuan Liu Guo-li Jing Hai-feng Tong Yuan Tian Qing-zeng Liu Department of Heart and Circulation 263 Clinical Department of Beijing PLA General Hospital Beijing 101149 China Department of Otolaryngology-Head and Neck Surgery 263 Clinical Department of Beijing PLA General Hospital Beijing 101149 China Department of Cardiology Chinese PLA General Hospital Beijing 100853 China Department of Emergency the 2nd Affiliated Hospital of Harbin Medical University Harbin 150001 China

Objective To explore the changes in plasma angiotensin II （Ang Ⅱ） and circadian rhythm of blood pressure among hypertensive patients with sleep apnea syndrome （SAS） before and after continuous positive airway pressure （CPAP） or surgical treatment. Methods A total of 180 essential hypertension patients were enrolled in our study. The determination of plasma Ang Ⅱ concentration, ambulatory blood pressure （ABP）, and polysomnography （PSG） monitoring were performed before and 3 months after CPAP or surgical treatment. Results Patients were classified into three groups by their apnea-hypopnea index （AHI）： essential hypertension group （EH group, n=72; AHI〈5）, essential hypertension with mild SAS group （EH＋mild SAS group, n=60, 5≤AHI〈20）, and essential hypertension with moderate and severe SAS group （EH＋moderate-severe SAS group, n=48, AHI_〉20）. The concentrations of plasma AngⅡ in the above three groups were 13.42±3.27, 16.17±3.82, and 18.73±4.05 ng/mL respectively before treatment, and AngⅡ concentration in EH patients combined with SAS was significantly higher than that in EH group （all P〈0.05）. After treatment the values in the latter two groups significantly decreased to 14.67±2.56 and 15.03±3.41 ng/mL respectively （P〈0.05）. The incidence of non-dipper blood pressure curve in EH patients was 31.9%, and those in hypertensive patients with mild SAS and moderate-severe SAS were 51.7% and 58.3%, respectively before treatment. The incidence of non-dipper blood pressure curve in the EH patients with mild SAS was significantly higher than that of patients with EH alone （P〈0.05）. After CPAP treatment or surgery, the incidence of non-dipper blood pressure curve in the two SAS groups was significantly decreased to 38.3% and 39.6%, respectively （P〈0.05）. Conclusions Ang Ⅱ might play a role in blood pressure variability in patients with obstructive SAS. CPAP or surgical treatment can improve blood pressure disorder and decrease plasma Ang Ⅱ level in patients with obstructive SA

关键词： hypertension sleep apnea syndrome circadian rhythm of blood pressure angiotensin Ⅱ continuous positive airway pressure surgery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Chinese Herbal Medicine for Calming Gan(肝) and Suppressing Hyperactive Yang on Arterial Elasticity Function and circadian rhythm of blood pressure in Patients with Essential Hypertension

引用

Chinese Journal of Integrative Medicine 2011年第6期17卷 414-420页

作者：钟广伟陈民敬罗艳红相玲丽谢启应李云辉张臣高峰 Institute of Integrated Traditional and Western Medicine Xiangya Hospital Central South University Department of Pathology The People's Hospital of Xiangxi Autonomous Region JishouHunan Province 416000China Institute of Hypertensive Disease Xiangya Hospital Central South University Department of Cardiopathy The Second People's Hospital of Hunan Province Department of Echocardiography The Third Xiangya Hospital Central South University

Objective：To observe the effect of Chinese herbal medicine for calming Gan（肝） and suppressing hyperactive yang（平肝潜阳,CGSHY） on arterial elasticity function and the circadian rhythm of blood pressure in patients with essential hypertension（EH）.Methods：Adopting a parallel,randomized design,sixty-four patients with EH of stagesⅠandⅡwere randomly divided into two groups according to a random number table,with 32 in each *** patients in the treatment group were treated with CGSHY and those in the control group were treated with *** patients were given 24-h ambulatory blood pressure monitoring（ABPM） before and after a 12-week ***/peak（T/P） ratios of systolic and diastolic blood pressure（SBP DBP） of each group were *** circadian rhythm of their blood pressure was observed at the same time. The changes in elasticity of the carotid artery in the patients,including stiffness parameter（β）,pressure-strain elastic modulus（Ep）,arterial compliance（AC）,augmentation index（Al）,and pulse wave velocity（PVWβ） were determined by the echo-tracking technique before and after a 12-week *** the meantime,their levels of nitric oxide（NO） and endothelin-1（ET-1） were measured ***：After treatment,all parameters in the 24-h ABPM and the elasticity of the carotid artery（β,Ep,AC and PVWβ） were markedly improved,the level of NO was increased,and ET-1 was decreased in both groups as compared with values before treatment （P0.05 or P0.01）.Further,the improvements in the ratio of T/P of SBP DBP and in the level of NO and ET-1 in the treatment group were more significant than those in the control group（P0.05）.There were no significant differences in all parameters in the ABPM monitoring and the elasticity of the carotid artery,the recovery of blood pressure circadian rhythm,and the therapeutic effect of antihypertension in EH patients between the two groups （P0.05）.Conclusions：Chinese herbal medicine for CGSHY may lower the blood pressure sm

关键词： essential hypertension circadian rhythm of blood pressure Chinese herbal medicine for calmingGan and suppressing hyperactive yang artery elasticity function

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：