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The circ_0002538/miR-138-5p/plasmolipin axis regulates Schwann cell migration and myelination in diabetic peripheral neuropathy

引用

Neural Regeneration Research 2023年第7期18卷 1591-1600页

作者： Yu-Tian Liu Zhao Xu Wei Liu Sen Ren He-Wei Xiong Tao Jiang Jing Chen Yu Kang Qian-Yun Li Zi-Han Wu Hans-GüNther Machens Xiao-Fan Yang Zhen-Bing Chen Department of Hand Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Plastic and Hand Surgery Technical University of MunichMunichGermany

Circular RNAs(circrnas)play a vital role in diabetic peripheral ***,their expression and function in Schwann cells in individuals with diabetic peripheral neuropathy remain poorly ***,we performed protein profiling and circrna sequencing of sural nerves in patients with diabetic peripheral neuropathy and *** profiling revealed 265 differentially expressed proteins in the diabetic peripheral neuropathy *** Ontology indicated that differentially expressed proteins were mainly enriched in myelination and mitochondrial oxidative phosphorylation.A real-time polymerase chain reaction assay performed to validate the circrna sequencing results yielded 11 differentially expressed ***_0002538 was markedly downregulated in patients with diabetic peripheral *** in vitro experiments showed that overexpression of circ_0002538 promoted the migration of Schwann cells by upregulating plasmolipin(PLLP)***,overexpression of circ_0002538 in the sciatic nerve in a streptozotocin-induced mouse model of diabetic peripheral neuropathy alleviated demyelination and improved sciatic nerve *** results of a mechanistic experiment showed that circ_0002538 promotes PLLP expression by sponging miR-138-5p,while a lack of circ_0002538 led to a PLLP deficiency that further suppressed Schwann cell *** findings suggest that the circ_0002538/miR-138-5p/PLLP axis can promote the migration of Schwann cells in diabetic peripheral neuropathy patients,improving myelin sheath structure and nerve ***,this axis is a potential target for therapeutic treatment of diabetic peripheral neuropathy.

关键词： circ_0002538 circrna sequencing competing endogenous RNAs demyelination diabetic peripheral neuropathy miR-138-5 myelination plasmolipin protein profiling Schwann cells

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