检索结果-南通市图书馆

cigarette smoking and alcohol drinking and esophageal cancer risk in Taiwan Residents women

World Journal of Gastroenterology 2010年第12期16卷 1518-1521页

作者： I-Chen Wu Deng-Chyang Wu Hung-Ju Su Hui-Jen Tsai Chien-Yu Lu Jang-Ming Lee Ming-Tsang Wu Division of Gastroenterology Department of Internal MedicineKaohsiung Medical University Hospital Faculty of Medicine College of MedicineKaohsiung Medical University Biomedical Engineering Research Laboratories Industrial Technology Research Institute Division of Hematology and Oncology Department of Internal MedicineKaohsiung Medical University Hospital Department of Surgery National Taiwan University Hospital Department of Family Medicine Kaohsiung Medical University Hospital Graduate Institute of Occupational Safety & Health Kaohsiung Medical University

AIM:To investigate the etiology of esophageal cancer among Taiwan Residents women.METHODS:This is a multi-center,hospital-based,case-control study.Case patients consisted of women who were newly diagnosed and pathology-proven to have esophageal squamous cell carcinoma(ESCC) from three large medical centers(one from Northern and two from Southern Taiwan,respectively)between August 2000 and December 2008.Each ESCC patient was matched with 4 healthy women based on age(within 3 years)and hospital of origin,from the Department of Preventive Medicine in each hospital.A total of 51 case patients and 204 controls,all women,were studied.RESULTS:Frequencies of smokers and drinkers among ESCC patients were 19.6%and 21.6%,respectively,which were significantly higher than smokers(4.4%) and drinkers(4.4%)among controls(OR=4.07,95%CI:1.36-12.16,P=0.01;OR=3.55,95%CI:1.03-12.27,P=0.04).Women who drank an amount of alcohol more than 158 g per week had a 20.58-fold greater risk(95%CI:1.72-245.62,P=0.02)of ESCC than those who never drank alcohol after adjusting for other covariates,although the sample size was small.CONCLUSION:cigarette smoking and alcohol drinking,especially heavy drinking,are the major risks for developing ESCC in Taiwan Residents women.

关键词： Esophageal squamous cell carcinoma Taiwan Residents women cigarette smoking Alcohol drinking

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interaction of Polymorphisms of Resistin Gene Promoter -420C/G, Glutathione Peroxidase -1 Gene Pro198Leu and cigarette smoking in Nonalcoholic Fatty Liver Disease

引用

Chinese Medical Journal 2015年第18期128卷 2467-2473页

作者： Chao-Xian Zhang Li-Ke Guo Yong-Mei Qin Guang-Yan Li Department of Gastroenterology The First Affiliated Hospital of Xinxiang Medical University Weihui Henan 453100 China Depatment of Stomatology The First Affiliated Hospital of Xinxiang Medical University Weihui Henan 453100 China

Background： Many studies have suggested that cigarette smoking and polymorphisms of resi stin and glutathione peroxidase-1 （GPx-1） genes are closely correlated with tile pathogenesis of nonalcoholic lhtty liver disease （NAFLD）. However, few reports have investigated these associations with respect to NAFLD susceptibility. We, therefore, exalnined the distribution of polymorphisms in GPx-l and resistin genes in NAFLD patients and healthy controls and analyzed the relationship between these polymorphisms and smoking status. Methods： Nine hundred NAFLD patients and 900 healthy controls were selected, and the genetic polymorphisms of resistin gene promoter- 420C/G and GPx- 1 gene Pro 198Leu were analyzed by polymorphism-polymerase chain reaction （PCR） in DNA extracted from peripheral blood leukocytes. Interactions between tile two mutants and the gene-environment interaction with cigarette smoking were also analyzed. Results： Genotype frequencies of 420C/G （GG） and Pro198Leu （LL） were significantly higher in NAFLD cases （49.56% and 50.11%, respectively） compared with healthy controls （23.67% and 24.22%, respectively）（P = 0.0069： P= 0.0072）. Moreover, the risk of NAFLD with 420C/G （GGJ was significantly higher than in controls （odds ratio [OR] =3.1685, 95% confidence interval （（7） 1.9366-5.2073）. Individuals carrying Pro198Leu （LL） had a high risk of NAFLD （OR - 3.1424, 95% C/= 1.7951 5.2367）. Combined analysis of the polymorphisms showed that the -420C/G （GG）/Pro198Leu （LL） genotype was significantly more common in the NAFLD group than in the control group （39.44% vs. 12.78%, respectively, P 0.0054）, while individuals with -420C/G （GG）/Pro198Leu （LL） had a high risk of NAFLD （OR = 5.（1357, 95% CI= 3.1852 7.8106）. Moreover, the cigarette smoking rate in the NAFLD group was significantly higher than in tile control group （OR = 1.8990, P = 0.0083 in the smoking index （SI） _〈400 subgroup： OR = 5.0937, P = 0.0051 in the SI 〉400 subgroup）, and statistical analysis suggested a positive interaction between cigarette smoking

关键词： cigarette smoking Glutathione Peroxidase-1 Gene Nonalcoholic Fatty Liver Disease Polymorphisnls Resistin GenePromoter （420C/G）

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Exercise Training Attenuated Chronic cigarette smoking-induced Up-regulation of FIZZ1/RELMα in Lung of Rats

引用

Journal of Huazhong University of Science and Technology(Medical Sciences) 2013年第1期33卷 22-26页

作者：马万里蔡鹏程熊先智叶红 Department of Respiratory Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Key Laboratory of Pulmonary Diseases Ministry of Health of ChinaTongji Medical CollegeHuazhong University of Science and Technology Department of Clinical Laboratory Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Pathophysiology Tongji Medical CollegeHuazhong University of Science and Technology

FIZZ/RELM is a new gene family named ＂found in inflammatory zone＂（FIZZ） or ＂re- sistin-like molecule＂（RELM）. FIZZ1/RELMct is specifically expressed in lung tissue and associated with pulmonary inflammation. Chronic cigarette smoking up-regulates FIZZ 1/RELMct expression in rat lung tissues, the mechanism of which is related to cigarette smoking-induced airway hyperresponsive- ness. To investigate the effect of exercise training on chronic cigarette smoking-induced airway hyper- responsiveness and up-regulation of FIZZ1/RELMct, rat chronic cigarette smoking model was estab- lished. The rats were treated with regular exercise training and their airway responsiveness was meas- ured. Hematoxylin and eosin （HE） staining, immunohistochemistry and in situ hybridization of lung tissues were performed to detect the expression of FIZZ1/RELMct. Results revealed that proper exercise training decreased airway hyperresponsiveness and pulmonary inflammation in rat chronic cigarette smoking model. cigarette smoking increased the mRNA and protein levels of FIZZ1/RELMct, which were reversed by the proper exercise. It is concluded that proper exercise training prevents up-regulation of FIZZ1/RELMct induced by cigarette smoking, which may be involved in the mechanism of proper exercise training modulating airway hyperresponsiveness.

关键词： exercise training cigarette smoking airway hyperresponsiveness lung rat FIZZ1/RELMct

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

cigarette smoking is Associated with Decreased Sperm Density

引用

Journal of Nanjing Medical University 2002年第4期16卷 141-148,155页

作者：邢厚恂陈常中王心如 JamesWOverstreet Department of Environmental Health School of Public Health Harvard University School of Public Health Nanjing Medical University Institute of Toxicology and Environmental Health University of California

Objectives To study the association between cigarette smoking and sperm density in men of reproductive age. Methods We enrolled 224 male employees of a modern petrochemical plant in Nanjing, China. These men had no prior history of infertility or other reproductive diseases. Epidemiologic data, including information on smoking and other occupational and lifestyle exposures were obtained by a questionnaire interview. Semen specimens were collected from each participant and analyzed according to the WHO guidelines. Regression analyses were performed to estimate the effect of smoking on sperm density. Results Approximately 67% of the subjects had ever smoked cigarettes. Different measurements of smoking behavior were each associated with decreased sperm density. There was a significant dose-response trend between the tertites of total smoking amount in pack-years and sperm density. As compared to men who never smoked, current smokers had a significant reduction in sperm density (-13.3×106/ml; 95% CI, - 24. 1, -2. 5) ,while ex-smokers had only a small decrement in sperm density ( -2. 6×106/ml; 95%CI, -18. 7,13. 5). Starting smoking at less than 20 years of age was associated with significant reduction in sperm density (- 14.8×106/ml; 95% CI, - 27. 4, -2. 2). Starting smoking at 20 years or older was associated with a slightly smaller decrease ( -10.1×106/ml; 95% CI,-21.7,1.4). Conclusions cigarette smoking is associated with decreased sperm density, showing an evident dose-response trend in this population.

关键词： cigarette smoking semen quality sperm density male reproduction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

THE STUDY ON RELATIONSHIP BETWEEN cigarette smoking AND THE p53 PROTEIN AND P21 PROTEIN EXPRESSION IN NON-SMALL LUNG CANCER

引用

Chinese Journal of Cancer Research 1996年第3期8卷 34-38页

作者：周宝森何安光朱继江王恩华

This paper discusses the relationship between cigarette smoking and the p53 protein and P21 protein expression by the immunohistochemical analysis in 93 cases with lung cancer in which squamous cell carcinoma accounted for 45 cases, adenocarcinoma 48 cases. The results showed that positive proportion of p53 protein expression was 74.20% (28 of 37 squamous cell carcinoma, 21 of 30 adenocarcinomas) in cigarette smoking group with lung cancers, and 38.46% (3 of 8 squamous cell carcinoma, 7 of 18 adenocarcinomas) in nonsmoking group with lung cancers. The difference was statistically significant. Odds ratio was 4.14 and confidence limits for OR was 1.42-12.52. A dose-related presents in the p53 protein expression for the smoking amount and smoking years. The positive proportion of P21 protein expression was 79.31% (21 of 28 squamous cell carcinoma, 25 of 30 adenocarcinomas) in cigarette smoking group with lung cancers, and 82.75% (10 of 11 squamous, 14 of 18 adenocarcinomas) in nonsmoking group with lung cancers, the difference was not statistically significant. But their positive proportion of P21 protein expression were very high in both groups. It was indicated that no relationship between cigarette smoking and the P21 protein expression. We suggest that the p53 gene could be a common target of tobacco-associated carcinogenesis in lung cancer.

关键词： p53 protein expression P21 protein cigarette smoking Lung cancer.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

cigarette smoking and the risk of endometrial cancer:A meta-analysis

引用

南京医科大学学报(自然科学版) 2008年第7期 939-939页

作者： Zhou,B. Yang,L. Sun,Q.M. Cong,R.H. Gu,H.J. Tang,N.P. Zhu,H.J. Wang,B.Nanjing Med Univ,Dept Pharmacol,Key Lab Reproduct Med,Nanjing 210029,Jiangsu,Peoples R China.Nanjing Med Univ,Affiliated Hosp 1,Dept Gen Surg,Nanjing 210029,Jiangsu,Peoples R China.Nanjing Univ,Sch Med,Affiliated Drum Tower Hosp,Nanjing 210008,Jiangsu,Peoples R China.

OBJECTIVE:Epidemiologic findings are inconsistent concerning the association of endometrial cancer risk with cigarette smoking.We conducted a meta-analysis of epidemiologic studies to examine this relation.METHODS:A systematic literature search up to June of 2007 was performed in MEDLINE and EMBASE.Study-specific risk estimates were pooled using a random-effects model.RESULTS:Ten prospective and 24 case-control studies were included in the analysis of the effect of ever smoking.Ever smoking was statistically significantly associated with a reduced risk of endometrial cancer among prospective studies(relative risk 0.81;95% confidence interval[CI],0.74-0.88) and case-control studies(odds ratio 0.72;95% CI,0.66-0.79).The inverse association was significant among current and former smokers.Six prospective and 6 case-control studies were included in the quantitative analysis.We noted that an increase in smoking of 20 cigarettes per day was statistically significantly associated with 16% and 27% reduced risks of endometrial cancer in prospective and case-control studies,respectively.We also found that cigarette smoking was significantly associated with a decreased risk of endometrial cancer among postmenopausal women(relative risk 0.71;95% CI,0.65-0.78) but not among premenopausal women.In addition,the risk reduction seemed to be stronger among hormone replacement therapy users than nonusers.CONCLUSION:cigarette smoking was found to be significantly associated with a reduced risk of endometrial cancer,especially among postmenopausal women.(C) 2008 Elsevier Inc.All rights reserved.

关键词： cigarette smoking endometrial cancer meta-analysis risk hormone-replacement therapy dose-response data alcohol-consumption postmenopausal women trend estimation estrogen use life-style aarp diet follow-up cohort

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Association of cigarette smoking with Hyperlipidemia in Male Individuals

引用

Food and Nutrition Sciences 2021年第10期12卷 937-949页

作者： Aminullah Jahan Shah Ali S. R. Alsubaie Bismillah Sehar Farrukh Sher Khan Nawsherwan Eltigani O. M. Omer Alia Mohammed Almoajel Falak Zeb Department of Occupational Medicine and Environmental Health School of Public Health Nanjing Medical University Nan-jing China College of Public Health Imam Abdurhman Bin Faisal University Dammam Saudi Arabia Department of Public Health National University of Medical Sciences Islamabad Pakistan Department of Preventive Medicine School of Health Sciences Wuhan University Wuhan China Department of Community Health Sciences College of Applied Medical Sciences King Saud University Riyadh Saudi Arabia Department of Human Nutrition and Dietetics National University of Medical Sciences Islamabad Pakistan

cigarette smoking is one of the major modifiable and environmental risk factors which can alter the lipid profile that leads to the progression of atherosclerosis and cardiovascular diseases. The aim of the current study is to explore the association of cigarette smoking with Hyperlipidemia in male individuals. A cross-sectional study was carried out from March 2017 to Au-gust 2018 in Xuzhou, Jiangsu, China. A total of 1561 male individuals were enrolled in the study with a mean age (years) of 55.33 ± 14.41. We collected data on demographic, anthropometric and lifestyle indices. Total cholesterol (TC), triglyceride (TGL), and high-density lipoprotein cholesterol (HDL-C) were determined by the enzymatic colorimetric method. The mean level of serum TC, TG, and HDL-C were 4.85 ± 0.91, 1.69 ± 1.45 and 1.27 ± 0.32 mmol/L respectively. We found that age, body mass index, pack-years, marital status, annual household income, alcohol consumption, smoking status, education level, and occupational status have significant association with Hyperlipidemia. Adjusted multiple logistic regressions showed that in old age, smoking behavior can significantly increase the risk of Hyperlipidemia. With an increase in pack-years, a significant increase is found only in TC while decreasing trend noticed in HDL-C level. Current smokers showed a significant increase in the risk of Hyperlipidemia compared to those who never smoked while smoking cessation decreases the risk of Hyperlipidemia. This study concluded that cigarette smoking along with increased age and pack-years can significantly increase the risk of Hyperlipidemia that further leads to heart diseases.

关键词： cigarette smoking Hyperlipidemia Lipid Profile Triglycerides

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of cigarette smoking with plasma metabolomic profiles

Association of cigarette smoking with plasma metabolomic pro...

引用

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青...

作者： Sha Huang Hua Fan Wenhui Wu Zhexuan Li Tong Zhou Yang Zhang Jingying Zhang Weicheng You Kaifeng Pan Wenqing Li Department of Cancer Epidemiology Peking University Cancer Hospital ＆amp Institute

Objective: Limited studies have explored the metabolomic profiles associated with cigarette smoking. This study aimed to investigate the association between cigarette smoking and plasma metabolomic profiles,and to identify individual metabolites associated with cigarette smoking.Methods: A total of 200 subjects were included based on the National Upper Gastrointestinal Cancer Early Detection Program in Linqu, Shandong Province of China. Information on cigarette smoking status and quantity of smoking（cigarettes/day） was collected using standardized questionnaires. Untargeted plasma metabolomic assay was performed using ultra-high performance liquid chromatography-mass spectrometry. We conducted unsupervised principal component analysis（PCA） to visualize metabolomic features comparing smokers and non-smokers. Associations between cigarette smoking and individual metabolites were examined using multiple linear regression models adjusting for age and sex.Results: Among 200 subjects, 52 were smokers. Our study demonstrated distinct metabolomic profiles between subjects with and without smoking by the score plot of PCA. At individual metabolite level, a total of nine metabolites were identified differentially distributed between smokers and non-smokers after correcting for multiple comparisons（false discovery rate-adjusted q-values＜0.05）, with six metabolites（theobromine, L-isoleucine, acetylcholine, isovalerylcarnitine, hydroxyphenyllactic acid and L-leucine） significantly upregulated and three（creatine, oleic acid and N1-methyl-2-pyridone-5-carboxamide） downregulated for smokers. Among them, two metabolites, including creatine and oleic acid were further significantly inversely associated with the quantity of cigarette smoking.Conclusion: Our study observed apparent changes in plasma metabolic profiles and a set of individual metabolites associated with cigarette smoking, with two metabolites, including creatine and oleic acid inversely associated with cigarette smoking status and the quantity of smoking. These findi

关键词： cigarette smoking Metabolomics Metabolite biomarkers

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Influence of Hypertension, Lipometabolism Disorders,Obesity and Other Lifestyles on SpontaneousIntracerebral Hemorrhage

引用

Biomedical and Environmental Sciences 2003年第3期16卷 295-303页

作者： JUN-FUZHOU JI-YUEWANG YAN-ERLUO HUAI-HONGCHEN SecondAffiliatedHospitalofCollegeofMedicine ZhejiangUniversity88JiefangRoadHangzhou310009ZhejiangChina AffiliatedChildren‘sHospital MedicalCollegeZhejiangUniversity57ZhuganLaneHangzhou310003ZhejiangChina FuyangMunicipalHospitalofTraditionalChineseMedicine 4BeimenRoadFuyang311400ZhejiangChina BrainMedicineResearchInstituteofZhejiangUniversity 88JiefangRoadHangzhou310009ZhejiangChina

Objective To investigate whether hypertension, abnormal lipometabolism, obesity, cigarette smoking and alcohol drinking affect the intracerebral hemorrhagic volumes (IHV) in patients with spontaneous intracerebral hemorrhage (SIHP), and to explore the roles of these factors in spontaneous intracerebral hemorrhage (SIH). Methods Five hundred patients with acute SIH and 200 healthy adult volunteers (HAV) were enrolled in a study of independently randomized controlled design, in which the levels of systolic pressure (SP) and diastolic pressure (DP), and total cholesterol (TCH), triacylglycerols (triglycerides, TG), high density lipoprotein cholesterol (HDL-CH), low density lipoprotein cholesterol (LDL-CH) in serum as well as the level of erythrocytic membrane cholesterol (EM-CH) were measured, and the body mass index (BMI), daily cigarette smoking consumption (DCSC) and daily pure alcohol consumption (DPAC) were calculated. Results Compared with the average parameters in the HAV group, those of SP, DP, TG, LDL-CH and BMI in the SIHP group were significantly increased (Pcigarette smoking consumption, and significantly decreased erythrocytic membrane cholesterol may be likely the main factors affecting intracerebral hemorrhagic volumes in

关键词： Blood pressure Lipids cigarette smoking Alcohol drinking Body mass index Spontaneous intracerebral hemorrhage Intracerebral hemorrhagic volume

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tiaobu Feishen therapy inhibits inflammation induced by cigarette smoke extracts in a human monocyte/macrophage cell line

引用

Journal of Traditional Chinese Medicine 2021年第3期41卷 360-366页

作者： QIN Yanqin CHEN Yulong ZHAO Peng FENG Suxiang WU Yaosong LIU Xuefang DONG Haoran ZHENG Wanchun MAO Xiaoning LI Jiansheng Henan Key Laboratory of Chinese Medicine for Respiratory Disease Henan University of Chinese MedicineZhengzhou 450046China Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan&Education Ministry of China Henan University of Chinese MedicineZhengzhou 450046China

OBJECTIVE: To study the mechanistic effects of Tiaobu Feishen therapy(TBFS) on inflammation induced by cigarette smoke extract(CSE) in a human monocyte/macrophage cell line.METHODS: The human monocyte/macrophage cell line THP-1 was stimulated with 10% CSE in the presence or absence of Bufei Yishen formula(BYF),Bufei Jianpi formula(BJF) and Yiqi Zishen formula(YZF). All formulations contained serum. Pro-inflammatory cytokines were measured in the supernatants using enzyme-linked immunosorbent assay.The activity of STAT3 DNA binding was detected using electrophoretic mobility shift assay and janus kinase/signal transducer and activator of transcription(JAK/STAT) pathway activation was assessed using Western blotting.RESULTS: The results showed that BYF, BJF and YZF treatment strongly decreased the CSE-induced secretion of interleukin(IL)-6, IL-8, tumor necrosis factor-α and matrix metalloproteinase-9 by THP-1 cells. Furthermore, BYF, BJF and YZF treatment attenuated STAT3 DNA binding capacity and JAK2 and STAT3 were shown to be phosphorylated.CONCLUSION: The data revealed that BYF, BJF and YZF effectively inhibited a CSE-induced inflammatory response in THP-1 cells by limiting activation of the JAK2/STAT3 pathway.

关键词： cigarette smoking janus kinase 2 STAT3 transcription factor THP-1 cells matrix metalloproteinases Tiaobu Feishen therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：