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Maintenance treatment with infliximab for ulcerative ileitis after intestinal transplantation: A case report

World Journal of Clinical Cases 2021年第19期9卷 5270-5279页

作者： Takumi Fujimura Yohei Yamada Tomoshige Umeyama Yumi Kudo Hiroki Kanamori Teizaburo Mori Takahiro Shimizu Mototoshi Kato Miho Kawaida Naoki Hosoe Yasushi Hasegawa Kentaro Matsubara Naoki Shimojima Masahiro Shinoda Hideaki Obara Makoto Naganuma Yuko Kitagawa Ken Hoshino Tatsuo Kuroda Department of Pediatric Surgery National Saitama HospitalWako ShiSaitama 351-0102Japan Department of Pediatric Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Pathology Keio University School of MedicineTokyo 160-8582Japan Center for Diagnostic and Therapeutic Endoscopy Keio University School ofMedicineTokyo 160-8582Japan Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Digestive Diseases Center International University of Health and WelfareMita HospitalTokyo 108-8329Japan Department of Gastroenterology and Hepatology Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND Evidence has been published on the successful applications of the anti-tumor necrosis factor alpha antibody infliximab,such as induction therapy,salvage treatment for acute cellular rejection,and treatment for chronic ulcerative inflammation,in intestinal transplant ***,the optimal protocol for the effective use of infliximab remains largely undetermined due to scarcity of available clinical *** report a continuative application of infliximab as maintenance therapy for recurrent chronic ulcerative ileitis in a recipient of isolated intestinal transplantation(ITx).CASE SUMMARY The patient was a 11-year-old boy with intestinal motility disorder classified as a hypogenic type of intestinal *** patient underwent living-donor related intestinal *** immunosuppression regimen consisted of daclizumab,tacrolimus,and *** he did not show rejection while on tacrolimus monotherapy,routine screening endoscopy showed several ulcerative lesions in the distal end of the graft 2 years after the intestinal *** work up to evaluate the progression of anemia revealed stenosis with ulcerative inflammatory changes and multiple longitudinal ulcers in the *** the endoscopic findings suggested ulcerative lesions in Crohn’s disease,infliximab treatment was *** with infliximab and a small dose of oral prednisolone afforded successful withdrawal of total parenteral nutrition and maintenance of a well-functioning graft without infectious complications for 5 years since the administration of the first dose of *** Infliximab is effective as maintenance therapy for recurrent chronic ulcerative ileitis in an isolated ITx patient.

关键词： Intestinal transplantation chronic ulcer Infliximab Crohn’s disease Tumor necrosis factor alpha Case report

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What’s old is new again:Insights into diabetic foot microbiome

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World Journal of Diabetes 2023年第6期14卷 680-704页

作者： Azza A H Rajab Wael A H Hegazy Department of Microbiology and Immunology Faculty of PharmacyZagazig UniversityZagzig 44511Egypt

Diabetes is a chronic disease that is considered one of the most stubborn global health problems that continues to defy the efforts of scientists and *** prevalence of diabetes in the global population continues to grow to alarming levels year after year,causing an increase in the incidence of diabetes complications and health care costs all over the *** major complication of diabetes is the high susceptibility to infections especially in the lower limbs due to the immunocompromised state of diabetic patients,which is considered a definitive factor in all *** foot infections continue to be one of the most common infections in diabetic patients that are associated with a high risk of serious complications such as bone infection,limb amputations,and life-threatening systemic *** this review,we discussed the circumstances associated with the high risk of infection in diabetic patients as well as some of the most commonly isolated pathogens from diabetic foot infections and the related virulence *** addition,we shed light on the different treatment strategies that aim at eradicating the infection.

关键词： Diabetic foot infection chronic ulcer Bacterial biofilm Multidrug resistance Methicillin resistant Staphylococcus aureus Vancomycin resistance

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Chinese Medicine and the Surgeon

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Chinese Journal of Integrative Medicine 2011年第7期17卷 548-555页

作者：梁秉中 Sreedhar Biji 杨重光 Institute of Chinese Medicine The Chinese University of Hong KongPrince of Wales Hospital Department of Surgery The Chinese University of Hong KongPrince of Wales Hospital

The surgeon aims at a direct,complete removal of the *** spite of the modern advancements of imaging facilities and precision instrumentations,unsatisfactory results and recurrences are not *** paper provides a general review of the four specific areas in surgery that would benefit from Chinese *** searches were made on four surgical areas based on available English language journals,***-back pain,chronic ulcers,renal calculus,and enuresis in children,in the past 10 *** quoted communications are mainly related to clinical evidences,while a smaller number of crucial laboratory reports are also ***-back paln,a most frequent orthopaedic problem,would benefit from acupuncture *** leg ulcers could achieve better results of healing using herbal *** of renal stones,besides the conventional methods of removal,could be further supplemented with herbal drinks that aim at prevention of *** in children,an untreatable common condition,may respond well to *** should keep an open *** case of difficulties,they could seriously consider options of traditional treatment.

关键词： Chinese medicine back pain nephrolithiasis enuresis chronic ulcer

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