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Assessment of the Level of Knowledge about chronic renal failure in 271 Hypertensive Patients in Brazzaville

Open Journal of Nephrology 2024年第1期14卷 25-36页

作者： Daniel Tony Eyeni Sinomono Ange Niama Gaël Honal Mahoungou Éric Gandzali-Ngabé Ndinga Berline Ngoma Precieux Dalia Mboungo Richard Loumingo Department of Nephrology University Hospital Center Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Department of Public Health Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo

Background and Objectives: chronic kidney disease (CKD) is now a global public health problem. In low- and middle-income countries such as the Congo, access to dialysis is low and inequitable. The prevention of CKD involves raising awareness among patients at risk, such as those suffering from arterial hypertension (AH), by improving their knowledge of CKD. The objectives of our work were to determine the level of knowledge about CKD among hypertensive patients and to identify the factors associated with a low level of knowledge. Methodology: We conducted a 3-month descriptive and analytical cross-sectional study from 1 August to 30 October 2023 in 3 large public hospitals in Brazzaville (capital of the Republic of Congo). We included: hypertensive patients aged 18 and over who had freely consented to participate in our study and were able to answer the questions on the survey form. Patients with known hypertension who had been followed for less than 3 years and those with known chronic renal failure were not included. Results: The mean age was 58.4 ± 14.4 years (29 - 88 years). There were 121 men and 150 women (sex ratio = 0.8). All the patients were educated;37.2% with a higher level of education and 13.6% with primary education. 24 patients (9%) had a good level of knowledge about CKD and 153 (56%) had poor knowledge. A good level of knowledge was associated with the duration of hypertension, intellectual level and the existence of associated heart disease. Conclusion: Our study reveals a significant lack of knowledge about chronic kidney disease among hypertensive patients in Brazzaville.

关键词： Knowledge chronic renal failure Hypertensives Brazzaville

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chronic administration of sildenafil improves erectile function in a rat model of chronic renal failure

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Asian Journal of Andrology 2015年第5期17卷 797-801,I0008-I0009页

作者： Nilgun Gurbuz Arif Kol Tumay Ipekci Erhan Ates Asli Baykal Mustafa F Usta Department of Biochemistry Akdeniz University School of Medicine Antalya Turkey Department of Urology Section of Andrology Akdeniz University School of Medicine Antalya Turkey

The relationship between erectile dysfunction （ED） and chronic renal failure （CRF） has been reported in several studies. This study aimed to investigate whether the chronic use of sildenafil could enhance the erectile capacity in CRF-induced rats. In addition, we assessed the effect of that treatment on certain molecules, which have been suggested to play crucial roles in erectile physiology and CRF-related ED as well. Three groups of animals were utilized：（1） age-matched control rats, （2） CRF-induced rats, （3） CRF-induced rats treated with chronic administration of sildenafil （5 mg kg^-1 p.o. for 6 weeks [treatment started after 6 weeks of CRF induction]）. At 3 months, all animals underwent cavernosal nerve stimulation （CNS） to assess erectile function. Penile tissue advanced glycation end products （AGE＇s）/5-hydroxymethyl-2-furaldehyde, malondialdehyde （MDA）, cGMP （ELISA）, inducible nitric oxide synthase （iNOS） and neuronal NOS （nNOS）（Western blot） analyses were performed in all rat groups. CRF-induced rats had a significant decrease in erectile function when compared to control rats （P 〈 0.05）. The increase in both intracavernosal pressure （ICP） and area under the curve of CRF-induced rats treated with sildenafil （Group 3） was greater than CRF-induced rats （Group 2）. Additionally, sildenafil treatment decreased AGE, MDA and iNOS levels, while it preserved nNOS and cGMP contents in CRF-induced penile tissue. Decreased AGE, MDA, iNOS and increased nNOS, cGMP levels at the sildenafil-treated group increased both ICP and Total ICP to CNS, which led to improve erectile function in CRF-induced rats. The results of the present study revealed the therapeutic effect of chronic sildenafil administration on erectile function in CRF-induced rats.

关键词： chronic renal failure erectile function sildenafil

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Effects of chronic renal failure on the expression of connexin 43 in the rat＇s corpus cavernosum

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Asian Journal of Andrology 2008年第2期10卷 286-289页

作者： Qiang Fu Jia-Jv Lv Hui Zhang Department of Urology Shandong Provincial Hospital Shandong University Jinan 250021 China

Aim： To explore the mechanism of chronic renal failure （CRF）-related erectile dysfunction （ED）. Methods： CRF experimental models were established by 5/6 nephrectomy from male Sprague-Dawley rats. Both the rats from the control group （NCRF group, n = 6） and the experimental group （CRF group, n = 30） were injected with a low dose （80 μg/g） of apomorphine in the 12th week after resection surgery to measure corresponding penile erections. Western blot method was thereafter conducted to measure the expression of connexin 43 （CX43） in the rat corpus cavernosum in the 12th week after the resection surgery. Results： There was one death in the NCRF group and five in the CRF group. The penile erection ratio of the CRF group was 28% （7/25）, whereas that of the NCRF group was 100% （5/5）, which presents a significant difference between the two groups （P 〈 0.05）. In terms of penile erection frequency, the average of the CRF group was 1.0 ± 0.0, which was significantly different from that of the NCRF group （2.2 ± 0.8）（P 〈 0.05）. As for the expression of CX43 in the rat corpus cavernosum, a notable difference existed between the CRF group （0.21 ± 0.07） and the NCRF group （0.53 ± 0.27）（P 〈 0.01）. Conclusion： CRF significantly reduces the erectile function of rats. A close correlation exists between the expression of CX43 in rats＇ corpus cavernosum and CRF-related ED. （Asian J Andro12008 Mar; 10： 286-289）

关键词： erectile dysfunction chronic renal failure connexin corpus cavemosum

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Effect of tadalafil in chronic renal failure rabbits:relevance to erectile dysfunction

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第6期12卷 455-459页

作者： Meng-yuan ZHANG Qiang FU Wei BIAN Department of Urology Provincial Hospital Affiliated to Shandong University Jinan 250021 China

It is of great importance to investigate an effective and reliable medication against chronic renal failure (CRF)-related erectile dysfunction (ED),which aims to improve patients' life *** concentrations of cyclic guanosine monophosphate (cGMP) in the corpus cavernosal smooth muscle of both CRF and control rabbits were *** effects of various concentrations of tadalafil,papaverine,and sodium nitroprusside on the relaxation responses of corpus cavernosal smooth muscle pre-contracted with phenylephrine in CRF rabbits were *** was significant difference in the concentration of cGMP between CRF and control rabbits (P<0.01).Tadalafil had the greatest impacts on CRF rabbits when given the same concentration of papaverine or sodium nitroprusside and particularly significant differences were identified under the concentration levels of 10-5 and 10-4 mol/L (P<0.01).The results suggest that the cGMP concentrations of the corpus cavernosum had been greatly reduced in CRF rabbits compared with control rabbits and that tadalafil may be an ideal medication for use in the treatment of CRF-related ED.

关键词： chronic renal failure Erectile dysfunction Phosphodiesterase inhibitor Tadalafil

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Wireless capsule endoscopy in the investigation of patients with chronic renal failure and obscure gastrointestinal bleeding (preliminary data)

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World Journal of Gastroenterology 2006年第32期12卷 5182-5185页

作者： Stephanos Karagiannis Spyros Goulas Georgios Kosmadakis Petros Galanis Dimitrios Arvanitis John Boletis Evangelos Georgiou Christos Mavrogiannis Academic Department of Gastroenterology Faculty of Nursing Athens UniversityGeneral Hospital of Athens "Helena Venizelou"Greece Department of Nephrology and Transplantation Center Laiko General Hospital AthensGreece Department of Nephrology A. Fleming General Hospital AthensGreece Medical Physics Department Medical School Athens UniversityGreece

AIM： To investigate the role of wireless capsule endoscopy （WCE） in detection of small bowel （SB） pathology in patients with chronic renal failure （CRF） and obscure bleeding. METHODS： Consecutive CRF patients with obscure bleeding were prospectively studied. Patients with normal renal function and obscure bleeding, investigated during the same period with WCE, were used for the interpretation of results. RESULTS： Seventeen CRF patients （11 overt, 6 occult bleeding） and 51 patients （33 overt, 18 occult bleeding） with normal renal function were enrolled in this study. Positive SB findings were detected in 70.6% of CRF patients and in 41.2% of non-CRF patients （P〈0.05）. SB angiodysplasia was identified in 47% of CRF patients and in 17.6% of non-CRF patients. Univariate logistic regression revealed CRF as a significant predictive factor for angiodysplasia （P〈0.05）. Therapeutic measures were undertaken in 66% of the patients with the positive findings. CONCLUSION： According to our preliminary results, SB angiodysplasia was found in an increased prevalence among CRF patients with obscure bleeding. WCE is useful in diagnosis of gastrointestinal pathologies and in planning appropriate therapeutic intervention and, therefore, should be included in the work-up of this group of patients.

关键词： chronic renal failure Obscure gastrointestinalbleeding Wireless capsule endoscopy Angiodysplasia

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Effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure

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World Journal of Gastroenterology 2005年第45期11卷 7183-7187页

作者： Selim Aydemir Binnaz Handan Ozdemir Gurden Gur Ibrahim Dogan Ugur Yilmaz Sedat Boyacioglu Department of Gastroenterology Department of Pathology

AIM： To evaluate the effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure （CRF）. METHODS： Forty-four patients were enrolled in this study and divided into four groups with respect to their Helicobacter pylori （H pylori） and CRF status. Groups were labeled as follows： la： normal renal function, H pylori negative （n = 12）, lb： normal renal function, H pylori positive （n = 11）, 2a： CRF, H pylori negative （n = 10）, 2b： CRF, H pylori positive （n = 11）. Upper gastrointestinal endoscopy was done in all the patients involved in the study. During endoscopical investigation, antral biopsy specimens were taken from each patient. In order to evaluate the cell apoptosis and proliferation in gastric epithelial cells, Bax and proliferating cell nuclear antigen （PCNA） labeling indexes （LI） were assessed with immunohistochemical staining method. RESULTS： For groups la, lb, 2a, and 2b, mean Bax LI was identified as 34.4±13.7, 44.1±16.5, 46.3±20.5, 60.7±13.8, respectively and mean PCNA LI was identified as 36.2±17.2, 53.6±25.6, 59.5±25.6, 67.2±22, respectively. When the one-way ANOVA test was applied, statistically significant differences were detected between the groups for both Bax LI （P = 0.004 〈0.01） and PCNA LI （P = 0.009 〈0.01）. When groups were compared further in terms of Bax LI and PCNA LI with Tukey＇s HSD test for multiple pairwise comparisons, statistically significant difference was observed only between groups la and 2b （P = 0.006 〈0.01）.CONCLUSION： In gastric epithelial cells, expression of both the pre-apoptotic protein Bax and the proliferation marker PCNA increase with H pylori infection. This increase is more evident in patients with uremia. These findings suggest that uremia accelerates apoptosis and proliferation in gastric epithelial cells.

关键词： Helicobacter pylori chronic renal failure Bax Proliferating cell nuclear antigen

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Doctor-led intensive diet education on health-related quality of life in patients with chronic renal failure and hyperphosphatemia

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World Journal of Clinical Cases 2022年第4期10卷 1217-1225页

作者： Xian-Dong Feng Xue Xie Rui He Fang Li Gui-Zhong Tang Medical Department Chengdu Second People’s HospitalChengdu 610021Sichuan ProvinceChina Chongqing Medical University School of Public Health and Management Medical and Social Development Research Centerand Collaborative Innovation Center for Social Risk Prediction and Governance in the Health FieldChongqing 400016China

BACKGROUND Secondary hyperparathyroidism,renal osteodystrophy,and cardiovascular adverse events can occur if long-term hyperphosphatemia is not corrected,leading to the adverse prognosis of patients with chronic renal *** the use of phosphorus binders,clinical control measures for hyperphosphatemia in these patients should also incorporate diet *** To observe doctor-led intensive diet education effects on health-related quality of life in patients with chronic renal failure and *** We assessed 120 patients with hyperphosphatemia and chronic renal failure on hemodialysis admitted to our hospital(July 2018 to March 2020).The control group(n=60)was given routine nursing guidance,and the observation group(n=60)was given doctor-led intensive diet *** changes in EQ-5D-3L scores,disease-related knowledge,and compliance scores before intervention and 3 and 6 mo after intervention in the two groups were *** levels of serum parathyroid hormone(iPTH),calcium(Ca),phosphorus(P),calciumphosphorus product(Ca×P),serum creatinine(Scr),and blood urea nitrogen(BUN)before intervention and 3 and 6 mo after intervention in the two groups were assessed along with patient *** There was no significant difference in blood iPTH,Ca,P,Ca×P,Scr,or BUN levels between the groups before *** 3 and 6 mo of intervention,the blood iPTH,Ca,P,and Ca×P levels in the two groups decreased gradually(P<0.05),but there were no significant differences in Scr or *** blood iPTH,Ca,P,and Ca×P levels in the observation group were lower than those in the control group(P<0.05).The satisfaction rate in the observation group after 3 mo was 93.33%and after 6,90.00%,which was high compared with the 80.00%and 71.67%,respectively,in the control group(P<0.05).There was no significant difference in EQ-5D-3L score between the two groups before *** 3 and 6 mo of intervention,the visual analogue scale score of the two

关键词： Dietary education chronic renal failure Hemodialysis Hyperphosphatemia Quality of life Satisfaction

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Evaluation of renoprotective effect of Chinese chive extracts on adenine-induced chronic renal failure

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Food Science and Human Wellness 2018年第4期7卷 260-265页

作者： Qiang-Ming Li Jian-Ping Luo Li-Hua Pan Xue-Qiang Zha School of Food Science and Engineering Hefei University of TechnologyHefei230009People’s Republic of China

The renoprotective effects of Chinese chive water and ethanol extracts(CCWE and CCEE)on adenineinduced chronic renal failure(CRF)mice were evaluated in this *** showed that the renal pathological damages and the enhancement of serum creatinine and blood urea nitrogen of CRF mice could be significantly alleviated by the treatment of CCWE,but not *** the concentration of CCWE reached 200 mg/kg/day,the area of renal pathological damage was decreased to the 48.1%of model group,and the levels of serum creatinine and blood urea nitrogen were decreased to the 87.7%and 83.9%of model group,***,it could be found that renal oxidative stress and inflammation of CRF mice were remarkably inhibited by *** results indicated CCWE could improve the kidney function of CRF mice via enhancing antioxidant ability and inhibiting inflammation,and was the main renoprotective fraction of Chinese chive.

关键词： Chinese chive Renoprotection chronic renal failure

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Pseudohyperkalemia caused by essential thrombocythemia in a patient with chronic renal failure: A case report

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World Journal of Clinical Cases 2020年第21期8卷 5432-5438页

作者： Yi Guo Hong-Chun Li Department of Laboratory Medicine The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221002Jiangsu ProvinceChina

BACKGROUND Hyperkalemia is one of the most common complications of chronic renal *** is caused by elevated levels of serum potassium in vitro and is usually accompanied by *** an elevated level of potassium is typically correlated with impaired renal function,pseudohyperkalemia has been rarely reported in patients with chronic renal ***,we conducted a review of the literature to study the case of pseudohyperkalemia caused by the essential thrombocythemia in a patient with chronic renal *** SUMMARY A 73-year-old woman was admitted to our hospital with complaints of palpitation,dyspnea,and acratia for 2 d and a history of essential thrombocythemia for 1 *** routine blood test showed platelet count of 1460×10^9/L,and biochemistry tests showed that the patient suffered from hyperkalemia(potassium:7.50 mmol/L)and renal failure(estimated glomerular filtration rate:8.88 mL/min).Initial treatment included medicines to lower her potassium-levels and ***,the therapy did not affect her serum potassium *** potassium concentration measurements and a history of essential thrombocythemia established the diagnosis of *** treatments of the platelet disorder gradually normalized serum potassium levels;however,the treatments had to be discontinued later due to the severe leukopenia,and enhanced levels of serum potassium concentrations were observable in the *** plasma sampling was not permitted,doctors had to use a diuretic just in ***,the patient collapsed into unconsciousness and died due to multiple organ dysfunction and electrolyte *** We reviewed the literature and suggest that serum and plasma potassium values should both be measured for patients whose platelet counts exceed 500×10^9/L to eliminate chances of pseudohyperkalemia,especially for those with chronic renal *** inappropriate treatment for pseudohyperkalemia can ag

关键词： Hyperkalemia Pseudohyperkalemia Thrombocythemia chronic renal failure Case report

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Individualized treatment of breast cancer with chronic renal failure: A case report and review of literature

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World Journal of Clinical Cases 2021年第33期9卷 10345-10354页

作者： Jie-Hui Cai Jie-Hua Zheng Xiao-Qi Lin Wei-Xun Lin Juan Zou Yao-Kun Chen Zhi-Yang Li Ye-Xi Chen Department of General Surgery The Second Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Breast Disease Research Center The Medical Research Institute of Shantou Doctoral AssociationShantou 515041Guangdong ProvinceChina

BACKGROUND Studies have shown that patients with chronic renal failure(CRF)are more likely to suffer from breast cancer and other malignant *** our knowledge,CRF can reduce drug excretion,thereby increase drug exposure and lead to increased toxicity,which will limit drug treatment and lead to tumor ***,there are few successful reports on the combination of docetaxel,trastuzumab,and pertuzumab(THP)as a neoadjuvant treatment regimen for breast cancer patients with *** SUMMARY We report a breast cancer(cT2N2M0,Her-2+/HR-)patient with *** was a clinical stage IIIA tumor on the left *** patient had suffered from uremia for 2 years,and her heart function was *** on the pathological type,molecular type,and clinical stage of breast cancer,and the patient’s renal function,the clinician analyzed the pharmacological and pharmacokinetic characteristics of the antitumor drugs after consulting the relevant literature,and prescribed the neoadjuvant regimen of THP(docetaxel 80 mg/m²,trastuzumab 8 mg/kg for the first dose,and 6 mg/kg for the maintenance dose with pertuzumab 840 mg for the first dose and 420 mg for the maintenance dose),once every 3 wk,for a total of 6 *** neoadjuvant treatment had a good effect,and the patient then underwent surgery which was *** CRF is not a contraindication for systemic treatment and surgery of breast *** THP regimen without dose adjustment may be a safe and effective neoadjuvant treatment for HER-2 positive breast cancer patients with CRF.

关键词： Breast cancer chronic renal failure Neoadjuvant treatment Dose adjustment Pertuzumab Case report

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