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chronic mountain sickness on the Qinghai-Tibetan plateau

Chinese Medical Journal 2005年第2期118卷 161-168页

作者： WUTian-yi HighAltitudeMedicalResearchInstitute Xining810012China

In 1925, Carlos Monge Medrano described a new illness that he called‘erythremia syndrome of high altitude', which is now known as‘chronic mountain sickness' (CMS) or‘Monge's disease' in his honour.

关键词： chronic mountain sickness hypoxic ventilation polycythemia pulmonary hypertension

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Intermittent Oxygen Inhalation with Proper Frequency Improves Overall Health Conditions and Alleviates Symptoms in a Population at High Risk of chronic mountain sickness with Severe Symptoms

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Chinese Medical Journal 2016年第11期129卷 1322-1329页

作者： Bin Feng Wei-Hao Xu Yu-Qi Gao Fu-Yu Liu Peng Li Shan-Jun Zheng Lu-Yue Gai Gang Zhang Department of Cardiology Chinese People's Liberation Army General Hospital Beijing 100853 China Department of High Altitucle Military Hygiene College of High Altitude Military Medicine Third MilitarY Meclical University Chongqing 400030 China Institute of Medicine and Hygienic Equipment for High Altitude Region College of High Altitude Military Medicine Third Military Medical University Chongqing 400030 China

Background： Oxygen inhalation therapy is essential for the treatment of patients with chronic mountain sickness （CMS）, but the efficacy of oxygen inhalation for populations at high risk of CMS remains unknown. This research investigated whether oxygen inhalation therapy benefits populations at high risk of CMS. Methods： A total of 296 local residents living at an altitude of 3658 m were included; of which these were 25 diagnosed cases of CMS, 8 cases dropped out of the study, and 263 cases were included in the analysis. The subjects were divided into high-risk （180 ≤ hemoglobin （Hb）〈210 g/L, n = 161） and low-risk （Hb 〈180 g/L, n = 102） groups, and the cases in each group were divided into severe symptom （CMS score ≥6） and mild symptom （CMS score 0-5） subgroups. Severe symptomatic population of either high- or low-risk CMS was randomly assigned to no oxygen intake group （A group） or oxygen intake 7 times/week group （D group）; mild symptomatic population of either high- or low-risk CMS was randomly assigned to no oxygen intake group （A group）, oxygen intake 2 times/week group （B group）, and 4 times/week group （C group）. The courses for oxygen intake were all 30 days. The CMS symptoms, sleep quality, physiological biomarkers, biochemical markers, etc., were recorded on the day before oxygen intake, on the 15th and 30th days of oxygen intake, and on the 15th day after terminating oxygen intake therapy. Results： A total of 263 residents were finally included in the analysis. Among these high-altitude residents, CMS symptom scores decreased for oxygen inhalation methods B, C, and D at 15 and 30 days after oxygen intake and 15 days after termination, including dyspnea, palpitation, and headache index, compared to those before oxygen intake （B group： Z = 5.604, 5.092, 5.741; C group： Z = 4.155, 4.068, 4.809; D group： Z = 6.021, 6.196, 5.331, at the 3 time points respectively; all P 〈 0.05/3 vs. before intake）. However, dyspnea/palpitation （A group： Z = 5.003, 5.428, 5.493,

关键词： chronic mountain sickness Efficacy Hypoxia Individualized Therapy Oxygen Inhalation

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Serum testosterone levels and excessive erythrocytosis during the process of adaptation to high altitudes

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Asian Journal of Andrology 2013年第3期15卷 368-374页

作者： Gustavo F Gonzales High Altitude Research Institute and Department of Biological and Physiological Sciences Faculty of Sciences and Philosophy Universidad Peruana Cayetano Heredia Lima 31 Peru

Populations living at high altitudes （HAs）, particularly in the Peruvian Andes, are characterized by a mixture of subjects with erythrocytosis （16 g dl-1〈haemoglobin （Hb）≤21 gdl-1） and others with excessive erythrocytosis （EE）（Hb〉21 g dl-1）. Elevated haemoglobin values （EE） are associated with chronic mountain sickness, a condition reflecting the lack of adaptation to HA. According to current data, native men from regions of HA are not adequately adapted to live at such altitudes if they have elevated serum testosterone levels. This seems to be due to an increased conversion of dehydroepiandrosterone sulphate （DH EAS） to testosterone. Men with erythrocytosis at HAs show higher serum androstenedione levels and a lower testosterone/androstenedione ratio than men with EE, suggesting reduced 17beta-hydroxysteroid dehydrogenase （17beta-HSD） activity. Lower 17beta-HSD activity via A4-steroid production in men with erythrocytosis at HA may protect against elevated serum testosterone levels, thus preventing EE. The higher conversion of DHEAS to testosterone in subjects with EE indicates increased 17beta-HSD activity via the A5-pathway. Currently, there are various situations in which people live （human biodiversity） with low or high haemoglobin levels at HA. Antiquity could be an important adaptation component for life at HA, and testosterone seems to participate in this process.

关键词： chronic mountain sickness DHEA haemoglobin high altitudes men oestradiol women

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