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ROLE OF TOLL-LIKE RECEPTOR 4 IN airway inflammation OF chronic OBSTRUCTIVE PULMONARY DISEASES

Journal of Shanghai Second Medical University(Foreign Language Edition) 2008年第1期20卷 38-41页

作者：周敏戎霞君万欢英黄绍光李彪李敏 Department of Respiratory Disease Ruijin Hospital School of Medicine Shanghai Jiaotong University

Objective To confirm if pulmonary epithelial cells express Toll-like receptor 4 （TLR4） and investigate the role of TLR4 in airway inflammation of chronic obstructive pulmonary diseases （COPD）. Methods The expressions of TLR4, IL-8 mRNA and NF-KB activation stimulated by differen factors E lipopolysacharides （LPS）, interleukin-lβ, cigarette smoking extract （CSE）] in pulmonary epithelial cells were investigated. Results LPS, CSE and IL-lβ induced the production of IL-8 and activation of NF-KB. The levels of 1L-8 mRNA and NF-KB protein in E1A ＋ cell were markedly higher than E1A- cell and A549 cell （ P 〈0. 05）. The TLR4 mRNA of all the cells increased along with the increase of LPS＇ stimulated time. There was significant difference among different LPS＇ doses （ 12 h： P = O. 039 ; 24 h ： P = O. 013 ）. The TLR4 mRNA of E1A ＋ cell was higher than the other two groups （ P 〈0. 05）. IL-lβ induced all the cells expressing TLR4 mRNA. CSE had no effect on the expression of TLR4 mRNA. Conclusion Pulmonary epithelial cells express TLR4. LPS and IL-lβ up-regulate IL-8 mediated via the activation of NF-KB induced by TLR4. But CSE up-regulates IL-8 mediated via the activation of NF-KB, which has no relation to TLR4 and may have another signal transduction pathway.

关键词： Toll-like receptor 4 pulmonary epithelial cells chronic airway inflammation

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The multifaceted role of placental growth factor in the pathogenesis and progression of bronchial asthma and pulmonary fibrosis:Therapeutic implications

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Genes & Diseases 2023年第4期10卷 1537-1551页

作者： Dan Huang Gege Liu Zhiyi Xu Shushu Chen Cuili Wang Dewei Liu Jiahao Cao Junfen Cheng Bin Wu Dong Wu Department of Respiratory and Critical Care Medicine Affiliated Hospital of Guangdong Medical UniversityZhanjiangGuangdong 524000China State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyAvenida Wai LongTaipaMacao SAR 999078China Department of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Guangdong Medical UniversityZhanjiangGuangdong 524000China

Placental growth factor(PlGF)is a glycosylated dimeric protein that is homologous to vascular endothelial growth factor(VEGF).PlGF expression is upregulated in patients with bronchial asthma,suggesting that it plays a role in the pathogenesis of *** asthma is characterized by chronic airway inflammation and airway hyperresponsiveness(AHR).After recurrent asthma attacks,pulmonary fibrosis develops and leads to airway remo-deling and a further decline in lung *** this review,we focused on the pivotal role of PlGF in chronic airway inflammation,AHR,and airway remodeling during bronchial ***,we summarized data showing that PlGF may be a potential therapeutic target in bronchial asthma.

关键词： AHR airway remodeling Bronchial asthma chronic airway inflammation PlGF

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