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Primary ovarian choriocarcinoma occurring in a postmenopausal woman:A case report

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World Journal of Clinical Cases 2023年第15期11卷 3592-3598页

作者： Guan-Lin Dai Fu-Rong Tang Dan-Qing Wang Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610041Sichuan ProvinceChina

BACKGROUND Nongestational ovarian choriocarcinoma(NGOC)is a rare but aggressive neoplasm with limited sensitivity to chemotherapy and a very poor *** cases of NGOC have been reported,and there is limited information regarding its clinical features,treatment protocols,or *** SUMMARY A postmenopausal woman in her 5th decade of life visited our clinic because of abnormal vaginal bleeding and an abdominal *** she had been menopausal for more than eight years and her last abortion occurred nine years ago,she had an increased level of serumβ-human chorionic gonadotropin(β-hCG).Thus,an ovarian neoplasm of trophoblastic origin was suspected,and exploratory laparotomy was *** on the patient’s clinical history and the histopathological examination and immunohistochemistry results obtained postoperatively,we concluded that she most likely had primary *** surgery was performed in combination with adjuvant chemotherapy comprising bleomycin,etoposide,and ***β-hCG levels decreased to normal after two cycles,and there was no evidence of recurrence after four cycles of *** Even in postmenopausal women,ovarian choriocarcinoma should be considered in the initial differential diagnosis for an adnexal mass.

关键词： Postmenopausal choriocarcinoma Ovarian neoplasm Non-gestational Trophoblastic Case report

One case of choriocarcinoma sellar region metastasis and literature review

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Chinese Neurosurgical Journal 2016年第1期2卷 -页

作者： Jin Sun Yanlin Huang Neurosurgery Department of Zhongshan Hospital affiliated with Xiamen University Xiamen China

Background:Chorionic carcinoma is a highly malignant gynecological tumor,frequently originating from trophoblastic cells in the uterus after *** erosion releases cancerous cells into the circulation to invade surrounding organs without primary symptoms and ***:One case of choriocarcinoma sellar region metastasis was analyzed,utilizing clinical data,MRI and pathological examinations,and clinical characteristics were ***:choriocarcinoma sellar region metastasis is easily *** examined the literature and original resources to summarize the clinical characteristics of choriocarcinoma sellar region metastasis and discuss available ***:This case study of a metastasis of choriocarcinoma to the sellar region provides important new data on the incidence and pathology of this rare disease.

关键词： choriocarcinoma Sellar region Brain metastasis Literature review

Primary Cervical choriocarcinoma: Case Report and the Review of Literatures

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Journal of Cancer Therapy 2013年第8期4卷 1335-1340页

作者： N. Behtash M. Karimi Zarchi A. A. Shamshirsaz A. A. Shamshirsaz Ashrafosadt Miratashi-Yazd N. Mehrdad Gynecological Oncology Fellowship Shahid Sadoughi University of Medical Science Yazd Iran

Background: Primary choriocarcinoma of the cervix is a very rare entity. Case: A 35-year-old patient had been admitted to our hospital with vaginal bleeding for 7 months. A cervical mass measured 4 × 4 cm was palpated on the anterior surface of the cervix. Biopsy of the lesion demonstrated extensive necrosis and was in favor of squamous cell carcinoma. Patient was accepted as FIGO stage Ib1-2 and underwent type II hysterectomy with bilateral salpingoopherectomy and bilateral pelvic lymph node dissection was carried out. Post operative pathologic evaluation of the surgical specimen evinced that the case was primary cervical choriocarcinoma. Conclusion: Primary choriocarcinoma of the cervix should be considered in patients in their reproductive years with cervical lesion and negative cervical cytology. Beta-hCG assay and transvaginal color Doppler sonography are useful for early diagnosis.

关键词： choriocarcinoma Cervix Primary

Tuberculosis Infected T Lymphocyte Spot as a Differential Diagnosis of Pulmonary Tuberculosis and choriocarcinoma Recurrence: A Case Report and Review of the Literature

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Journal of Biosciences and Medicines 2023年第9期11卷 31-36页

作者： Qi Wu Zhaoping Chu Jun Dai Ligang Jia Xinling Wang Lihui Li Jie Li Yuan Zhang Ping Yan Jianxiang Hou Department of Gynaecology Hebei General Hospital Shijiazhuang China Department of Immunology and Pathobiology Hebei University of Chinese Medicine Shijiazhuang China Department of Gynaecology The Fourth Hospital of Shijiazhuang Shijiazhuang China

Introduction: choriocarcinoma is an aggressive tumor, whose incidence is 0.18 per 100,000 women between the ages of 15 and 49 years [1]. Although its prognosis has improved with the development of chemotherapy regimens, the mortality rate of patients with brain metastases is reportedly 29.7% [2]. After chemotherapy, most often, the reappearance of masses in pulmonary is considered to be a sign of relapse. Case presentation: The patient was a 32-year-old Asian Chinese female who delivered a dead male infant at 33 weeks gestation. The placenta appeared to be normal. The major presentation was a haemorrhage of the vagina. The patient received combined treatment with systematic multi-agent chemotherapy and whole-brain radiation therapy at the General Hospital of Hebei Province and achieved complete remission. Two years after remission, a chest CT scan revealed a mass in the right lung that had become larger over 6 months. The patient’s serum β-human chorionic gonadotropin (β-HCG) level was normal, and the tuberculosis infected T lymphocyte spot (***) tests were positive. The patient was started on anti-tuberculosis therapy, after which the size of her right lung mass decreased. Conclusion: Lung masses after choriocarcinoma require extensive laboratory and imaging exams to exclude recurrence. This case highlights the importance of differential diagnoses of lung masses in patients with choriocarcinomas. Imaging studies, β-HCG and local lesion resection should be employed to rule out choriocarcinoma recurrence.

关键词： choriocarcinoma Tuberculosis

Immunoscreening of Alpha-Tocopherol in Breast, Prostate Cancers and in Gestational choriocarcinoma Tissues

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CellBio 2021年第2期10卷 11-21页

作者： Henriette Poaty Franck Arnaud Moukobolo Kinsangou Alexis F. Bolenga Liboko Judith Nsonde Malanda Michel Geffard Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo National Research Institute on Health Sciences (IRSSA) Brazzaville Congo Oncology Service Teaching hospital Brazzaville Congo Institut pour le Développement de la Recherche en Pathologie Humaine et Thérapeutique Talence France

Background: Many literature reviews report vitamin E supplementation as a benefit chemopreventive and adjuvant therapy in breast and prostate cancers. We investigated in the present work, alpha-tocopherol (α-T) expression (the current active form of vitamin E) from tissues of Congolese patients neither smokers nor alcohol drinkers and without intake antioxidant vitamins supplement. Methods: α-T was analysed in one normal placenta of nine weeks of gestation and in nineteen cancerous tissues, including seven breast cancers, six prostate cancers, and six gestational choriocarcinomas. The study was performed by immunohistochemistry method after diagnosis confirmation by histological analysis. Results: α-T staining in membrane cells and collagen fibers presented a moderate expression in healthy sections of tissues (positive control), but the labelling was strong in breast, prostate adenocarcinomas, and in choriocarcinomas. Conclusion: Tumors immunohistochemistry of α-tocopherol in breast, prostate cancers and in choriocarcinoma show elevated immunostaining suggesting a probable oncogenic effect of the micronutrient.

关键词： Vitamin E Alpha-Tocopherol Immunohistochemistry Breast Cancer Prostate Cancer choriocarcinoma

Effective component from verbena officinalis *** proliferation and induces apoptosis of human choriocarcinoma JAR cells

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生殖医学杂志 2005年第B10期14卷 12-18页

作者：徐珊陈琪徐昌芬 Key Laboratory of Human Functional Genomics of Jiangsu Province Nanjing Medical UniversityNanjingJiangsu 210029China Key Laboratory of Reproductive Medicine of Jiangsu Province Nanjing Medical UniversityNanjingJiangsu 210029China

Objective:To examine the action of the effective component,4'-methylether-scutellarein,from Verbena officinalis L.(VOL)on the proliferation and apoptosis of human choriocarcinomaJAR ***:Cell proliferation was measured by MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-di-phenyl tetrasodium bromide,MTT]assay and the incorporation of tritiated thymidine(~3H-TdR).Apoptosis of cell was evaluated by flow cytometry(FCM)and the characteristic apoptoticDNA ladder by agarose gel electrophoresis,and the morphological changes of apoptotic JAR cellswere observed under fluorescence microscopy and electron microscopy(EM).Expressions of ap-optosis proteins,poly(ADP-ribose)polymerase(PARP)and caspase-3,-8,and -9 were deter-mined with Western ***:The effective component from VOL inhibited the proliferation of JAR cells in a dose-and time-dependent *** treated cell cycle was arrested in S phase and an apoptotic peakwas found in S phase using FCM analysis.A typical DNA ladder appeared in the treatment groupwhen analyzed by agarose gel *** fluorescence microscopy,the percentage ofapoptotic cell was 0.9%,6%,and 14% after treatments of 10,20,and 40 mg·L^(-1) of the effec-tive component,respectively,for 48 *** apoptotic changes,such as condensed chromatinand presence of apoptotic bodies,were observed under *** with effective componentfor 48 h and 72 h also induced protein expression of PARP and caspase-3,-8,and -9 as seen byWestern ***:The effective component from VOL inhibits cell proliferation and induces apop-tosis in human choriocarcinoma JAR cells.

关键词： Anti-cancer choriocarcinoma 4’-methylether-scutellarein Verbena officinalis L. Apoptosis

Rapid Evolution of a Case of choriocarcinoma Following Normal Delivery at Term Pregnancy

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Open Journal of Obstetrics and Gynecology 2022年第11期12卷 1215-1218页

作者： Nafiou Idi Mahamadou Garba Hannatou Sanoussi Rahmatou Madeleine Garba Madi Nayama Niamey Niger

We report a case of postpartum choriocarcinoma with rapid evolution. The patient died 6 months after diagnosis. We underline the interest of the systematic histological examination of any pregnancy tissue, particulary... 详细信息

关键词： choriocarcinoma Postpartum Prognosis Niamey

Complete response to multidisciplinary therapy in a patient with primary gastric choriocarcinoma

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World Journal of Gastroenterology 2013年第31期19卷 5187-5194页

作者： Kazuhiro Takahashi Shigeki Tsukamoto Ken Saito Nobuhiro Ohkohchi Katsu Hirayama Division of Gastro-enterological and Hepatobiliary Surgery and Organ Transplantation Department of Surgery University of Tsukuba Tsukuba 3058575 Japan Department of Surgery Hiraka General Hospital Yokote 0138610 Japan

Primary gastric choriocarcinoma is a rapidly growing neoplasm with an average survival of several months in untreated *** with lymph node dissection followed by chemotherapy is the treatment of *** used for gastric adenocarcinoma are usually ***,median survival remains less than six *** this case report,we describe a case of primary gastric choriocarcinoma with a clinical complete response to multidisciplinary treatment including surgery,chemotherapy,and radiofrequency ablation(RFA).The patient was originally referred for general *** demonstrated a large tumor occupying the fornix,and total gastrectomy with lymph node dissection was *** days later,multiple liver metastatic recurrences with high serum levels of beta-human chorionic gonadotropin(β-hCG) were *** with a gonadal choriocarcinoma regimen consisting of etoposide,methotrexate,actinomycin D,cyclophosphamide,and vincristine(EMA/CO),was *** three cycles,serum β-hCG decreased markedly and the tumors *** months later,multiple lung metastatic recurrences were *** one cycle of EMA/CO,only one nodule *** tomography-guided RFA was performed for this oligometastatic *** patient has been alive with no evidence of disease for 10 years after the initial *** the best of our knowledge,this patient with recurrent primary gastric choriocarcinoma has achieved the longest *** present case is the first report of choriocarcinoma metastatic to the lung successfully treated with *** our retrospective analysis of recurrent or unresectable primary gastric choriocarcinoma,we propose that gonadal choriocarcinoma regimens can be considered as first-line for primary gastric choriocarcinoma.

关键词： Primary gastric choriocarcinoma Betahuman chorionic gonadotropin Etoposide,methotrexate,actinomycin D,cyclophosphamide,and vincristine Oligometastatic Radiofrequency ablation

Uterine choriocarcinoma: A gynaecological masquerader case report and review of the literature

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Modern Chemotherapy 2013年第4期2卷 69-72页

作者： Eguzo Kelech Chisara C. Umezurike Emmanuel Akwuruoha Abia State University Teaching Hospital Aba Nigeria Nigerian Christian Hospital Aba Nigeria

Background: choriocarcinoma is a rare clinical condition, and its diagnosis may be difficult, especially in resource-limited settings. Case Presentation: A 38-year old para 2 woman is with a 4-month history of intractable vaginal bleeding and offensive vaginal discharge, but without antecedent pregnancy. She had previously been managed at various tertiary medical institutions where several pelvic ultrasound scans and even histology of endometrial curette could not clinch the diagnosis. The diagnosis of choriocarcinoma was made by a serial strip-based pregnancy testing, which was still positive at 1:200 dilutions. She was treated with chemotherapy involving Adriamycin, Cyclophosphamide, Methotrexate and Folinic acid. Conclusion: The diagnosis of choriocarcinoma may be difficult especially when it develops ab initio without preceding abortion, molar or term pregnancy. In settings where serum hCG assay may be not available, the simple strip-based pregnancy test in dilution could be helpful in its diagnosis and treatment monitoring.

关键词： choriocarcinoma Chemotherapy Human Chorionic Gonadotropin Resource-Limited Settings