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Aggregation and self-coiling of organic molecules——Why are cholesterols and triglycerides culprits of arteriosclerosis?

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Progress in Natural Science:Materials International 1995年第5期 17-25页

作者：蒋锡夔孙思讯 China Chinese Academy of Sciences Shanghai 200032 Shanghai Institute of Organic Chemistry

Neutral organic molecules may cluster together and form simple aggregates (Ag’s) in water or aquiorgano mixtures, i.e. solvents with "solvent aggregating power (SAgP)". Molecules which can form Ag’s are called aggregator (Agr) *** cluster or simple Ag contains only a small number of Agr molecules, perhaps 3 to 15. When aggregates are composed of more than one kind of Agr molecules,they are called coaggregates, or CoAg’s. Aggregator molecules usually carry at least

关键词： aggregation self-coiling cholesterols aggregating tendency ESAg deaggregators.

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EFFECTS OF ACUPUNCTURE ON ANGINA PECTORIS,ECG AND BLOOD LIPIDS OF PATIENTS WITH CORONARY HEART DISEASE

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World Journal of Acupuncture-Moxibustion 1993年第4期3卷 15-19页

作者： Mao Xirong Anhui Literature Institute of TCM,Hefei 230001,ChinaWang Yuelan Zhou Yiping Institute of Acupuncture and Meridian,Anhui College of TCM,Hefei 230038,China

Sixty patients with coronary heart disease were divided into two groups on thebasis of western medicine treatment,30 cases in each *** was given acupuncture treatmentadditionally,the other as *** one course of treatment,it was found that the total effectiverate was 85. 71% clinically;the ameliorative rate of abnormal ST-T segment was 68. 97%, inacupuncture *** effectiveness was obviously higher than that of western drug ***,the levels of serum TC,TG,LDL-C,APOB100 and BS were obviously lower than thatof pre-acupuncture,while HDL-C and APOA1 were markedly increased,and the values of all aboveindices after treatment in acupuncture group were significantly different from that of post-treatment indrug *** show that acupuncture has functions of regulating the disturbance of fatmetabolism and preventing coronary heart disease.

关键词： Coronary heart disease ECG cholesterols HDL LDL

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SND1 promotes cholesterol synthesis and ameliorates high fat diet-induced hepatic steatosis and insulin resistance in mice

SND1 promotes cholesterol synthesis and ameliorates high fat...

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第十一届全国免疫学学术大会

作者： Wang Xinting Lingbiao Xin Zhongchao Duan Zhiyu Zuo Ruanruan Ren Xin Liu Lin Ge Silvennoinen Olli Minxin Wei Zhi Yao Xi Yang Jie Yang Tianjin Medical University University of Tampere Tianjin Medical University General Hospital University of Manitoba

Aim: Staphylococcal nuclease domain containing 1(SND1) transcriptionally activates adipogenesis and regulates adipocyte differentiation, but its contribution to the metabolic homeostasis in vivo is unclear. The current study aimed to explore impact of SND1 overexpression in vivo on high-fat diet-induced(HFD) nonalcoholic fatty liver disease(NAFLD).Method: Wild-type and globally expressed SND1 transgenic mice on C57BL/6 were fed a high-fat diet for 12 ***: Compared to wild-type mice, the HFD in transgenic mice induced lower liver and body weight as well as decreased hepatic steatosis and elevated hepatic cholesterol and LDL-cholesterol in the blood. Microarray profiling on HFD-liver revealed a series of genes involved in hepatic cholesterol biosynthesis were increased, which was associated with activation of sterol regulatory element-binding protein 2(SREBP2) through SREBP cleavage-activating protein(SCAP). In human hepatoma cells, chromatin immunoprecipitation assay revealed the binding of SND1 to the Scap promoter, and transient transfection with full length SND1 activated a Scap promoter-reporter in response to free fatty acids or TNFa, identifying Scap as a SND1 direct transcriptional target. Biopsy studies from NAFLD patients confirmed a significant correlation between SND1 and Scap mR NA expression in human liver tissues. Inflammation experiments showed an elevated inflammatory state in HFD-Tg liver with increased Tnfa expression. More importantly, HFD-transgenic mice show increased level of circulating leptin derived from larger white adipose mass characterized by active de novo lipogenesis in fat. Moreover, SND1 transgenic mice in high fat diet protected from insulin resistance, central to NAFLD pathogenesis, evidenced by increased insulin sensitivity both in mice liver and primary ***: SND1 regulates cholesterol metabolism and improve liver steatosis and insulin resistance in nonalcoholic fatty liver disease.

关键词： NAFLD SREBP SCAP leptin insulin resistance phospholipids cholesterols

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